Zur Differenzierung verschiedener Antikörper gegen nucleäre und cytoplasmatische Zellbestandteile bei Lupus erythematosus disseminatus

Ohne Zusammenfassung Jetzige Anschrift: Medizinische Universit?ts-Poliklinik, Marburg. a. d. Lahn, Robert-Koch-Stra?e 7a.     

High doses of neomycin sulfate and the absorption of glucose and xylose from the rat small intestine

Summary Neomycin sulfate, at doses of 250 mg./kg. or 2 gm./kg., was instilled intragastrically, in male Fisher-strain rats daily for 21 days. Pair-fed controls received an equal amount of saline intragastrically for an equal period. After 3 weeks of treatment animals were tested by our modification of the Cori method to assess the absorption of xylose, glucose, and a mixture of xylose and glucose. Rats receiving neomycin at both doses demonstrated an enhanced absorption of glucose. A significant reduction in the absorption of xylose was noted in animals treated with 2 gm./kg. of neomycin. When glucose and xylose were administered together to rats receiving 2 gm./kg. of neomycin, a significant reduction in the absorption of xylose and an enhancement in the absorption of glucose was observed.Histologic examination revealed no constant alterations in the appearance of the small intestinal mucosa of the neomycin-treated rats.Supported in part by the Georgetown Univerity Medical School General Research Fund and by Grant AM 07125 from the U. S. Public Health Service.The technical assistance of Paula Meyer, James Robbins, and Joel Taubin is gratefully acknowledged, and we would like to thank Dr. Robert Damiano, The Upjohn Company, Kalamazoo, Mich., for supplying neomycin sulfate.     

Psychopathology and coping in recently diagnosed HIV/AIDS patients--the role of gender.

BACKGROUND: Although there is growing literature on the psychological responses to and the psychopathology associated with HIV/AIDS, few investigations have focused on the role of gender. This study compared psychiatric morbidity, coping responses, and disability in male and female outpatients recently diagnosed with HIV/AIDS. METHOD: One hundred and forty-nine patients (44 male, 105 female) with HIV/AIDS (mean +/- standard deviation (SD) months since diagnosis 5.8 +/- 4.1) attending an infectious diseases clinic at Tygerberg Hospital, Cape Town, were evaluated. Subjects were assessed using the MINI International Neuropsychiatric Interview (MINI), the Carver Brief COPE, and the Sheehan Disability Scale. In addition, negative life events and risk behaviours were evaluated. RESULTS: Fifty-six per cent of patients were diagnosed with a psychiatric disorder, most commonly major depression (34.9%), dysthymic disorder (21.5%), post-traumatic stress disorder (14.8%), and alcohol dependence (10.1%). There were no significant gender differences in the prevalence of mood disorders in the sample. Men, however, were more likely than women to meet diagnostic criteria for alcohol abuse or dependence, and to engage in certain risky sexual behaviours. Women were more likely to suffer from post-traumatic stress disorder, and to use coping strategies of planning and religion to deal with the illness. There were no significant gender differences in disability. CONCLUSION: Psychiatric disorders are common in recently diagnosed HIV/AIDS patients in South Africa. Clinicians should be aware of the high prevalence of mood disorders in both men and women, and of gender-different responses such as increased alcohol and substance use and more risky sexual behaviour in men.     

Ein isoliertes Nerv-Muskelpräparat des M. serratus der Ratte

Zusammenfassung Es wird über ein neues Nerv-Muskelpräparat der Ratte, das aus dem N. thoracicus longus und dem M. serratus lat. besteht, berichtet und dessen Präparation dargestellt. Die Reaktionen auf Acetylcholin, d-Tubocurarin und Dekamethonium unter normalen Bedingungen, nach chronischer Denervierung und nach Tenotomie werden mitgeteilt. Obgleich histologisch zwischen M. serratus lat. und dem Diaphragma der Ratte Unterschiede bestehen, gleichen sich die Reaktionen der beiden Muskeln auf die genannten Pharmaka und auf tetanische Reizung.Mit 3 Textabbildungen.     

Beteiligung des dorsalen Vaguskerns bei Ösophagus-und Magenkarzinom sowie Magenulcus

Journal of Neural Transmission - In 19 menschlichen Fällen wurde in Längsschnitten durch den Bulbus der dorsale Vaguskern beiderseits untersucht, wovon 3 Ösophaguskarzinomen und 8...     

Hyperbaric oxygen therapy in a patient with autosomal dominant polycystic kidney disease with a perinephritic abscess

A 68-year-old female in hemodialysis due to autosomal dominant polycystic kidney disease underwent resection of cysts in her right kidney via a laparoscopic approach due to abdominal pain. Three weeks after surgery, she was admitted with sepsis. A CT scan showed a large abscess around the right kidney. Percutaneous drainage of abscess was performed. The pus smear showed Gram-positive cocci and the culture contained methicillin-resistant Staphylococcus aureus. Ciprofloxacin, clindamycin and vancomycin were given. In the 3 weeks following admission, she remained febrile and septic and showed a progressive deterioration in her general condition, along with malnutrition and persistent drainage of purulent material from her right flank. The antibiotic therapy was changed to vancomycin, metronidazole and meropenem, but no improvement was observed. Because of the high risk associated with carrying out an open nephrectomy, we decided to use hyperbaric oxygen therapy (HBOT) as a potentially useful measure to control her infection. The patient underwent 26 daily sessions of 100% hyperbaric oxygen (2.5 atm). The use of HBOT induced a notable break in the clinical course of this patient’s retroperitoneal infection. She was discharged after day 58 without any signs of inflammatory activity, and she has not presented reactivation of infection since then. We think that this case suggests that this therapy could be a new therapeutic tool in the management of patients with similar clinical features when all other therapeutic measures have failed. We did not find any other reports of the use of HBOT in infections of renal cysts.