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11.
B. S. Kamps H. -R. Brodt S. Staszewski L. Bergmann E. B. Helm 《Journal of molecular medicine (Berlin, Germany)》1994,72(4):283-287
The clinical history of 1538 HIV positive patients was analyzed on the basis of the new CDC classification system of HIV disease and AIDS. This classification system combines three CD4 cell categories (1, 2, and 3) with three clinical categories (A, B, and C) into nine subgroups AI–C3. We examined the overall survival for all subgroups and the AIDS-free survival for subgroups Al–B3. AIDS-free survival for patients in subgroups Al, A2, and B1 was considerably longer than survival in patients from subgroups A3, B2, and B3 (P < 0.0001). According to these findings, the new CDC classification system could be simplified into three stages, stage I and II comprising the above mentioned six subgroups, and stage III comprising clinical AIDS defining categories C1, C2, and C3. These three stages correspond to different periods in the management of HIV positive patients, i.e., period of observation, period of prophylaxis, and period of treatment.Abbreviations AIDS
acquired immunodeficiency syndrome
- CDC
Centers for Disease Control
- HIV
Human immunodeficiency virus
Correspondence to: E.B. Helm 相似文献
12.
13.
A survey to determine the status of burn rehabilitation services in the United States was developed and sent to 186 burn treatment facilities. The facilities were divided into four groups based upon number of admissions per year (0 to 80, 81 to 120, 121 to 200, and 200+). Completed surveys were received from 114 facilities. Results indicated that burn facilities of different sizes were consistent with respect to the severity of burn injuries treated, the length of hospitalization for acute injuries, and the duration of physician follow-up after discharge. Burn facilities with more admissions were more likely to report (1) organized outpatient burn rehabilitation programs, (2) available specialized burn rehabilitation personnel, (3) regular interdisciplinary inpatient staffing conferences and outpatient clinics, and (4) structured educational activities for staff and Full-time equivalent burn rehabilitation personnel were equally represented across facilities of different sizes. The overall results suggest that there have been substantial improvements in the comprehensiveness of burn rehabilitation care since a previous survey in 1983. Minimum guidelines for burn rehabilitation are suggested based upon the relative consistency between burn facilities indicated by the survey results. 相似文献
14.
15.
Dr. M. Bernhard W. Zink M. Sikinger A. Aul M. Helm T. S. Mutzbauer S. Doll A. Völkl A. Gries 《Notfall & Rettungsmedizin》2005,8(6):399-407
Prehospital emergency medicine in Germany is based on a specially trained physician-staffed system, in order to realize a differentiate therapy at the scene. In the last years, the special education and the qualification were more and more discussed after the determination of deficits in the prehospital management of special emergency situations. In the presented paper we described the concept and organization of a practice-oriented training model of invasive emergency techniques, as like as the emergency cricothyrotomy, the thoracic tube and the intraosseous access. The relevance and the efficacy are discussed based on an evaluation of the participants. Practice-oriented training models seem to be adequate instruments in order to close the leak in educational programs and can help to improve the qualification of the physician-staffed system, generally. 相似文献
16.
E Rosset C Brunet B Meunier PA Marie V DiMarino M Argème J Farisse 《Surgical and radiologic anatomy : SRA》1995,17(1):1-5
We studied specimens from 50 cadavers (27 men and 23 women) to obtain anatomical data concerning the liver and its attachments. The results allowed us to develop a polyglactin perihepatic prosthesis for compression of the injured liver. The falciform ligament and a narrowing of the hepatic parenchyma at this level allow attachment of the prosthesis. Separate prostheses were designed for each lobe. Clinical use has demonstrated that our prosthesis can be used to achieve effective control of haemorrhage and bile leakage.
Etude anatomique du foie. Développement d'une prothèse péri-hépatique
Résumé Sur une série de 50 pièces anatomiques d'adultes (27 hommes, 23 femmes), l'étude morphométrique du foie, de ses attaches dorsales et leurs variations a permis la confection d'une prothèse périhépatique en polyglactine adaptable à chaque lobe et fixée grâce à des artifices anatomiques. Celle-ci assure une compression efficace du parenchyme lésé et donc une hémostase et une bilistase correctes. Le ligament falciforme et le rétrecissement du parenchyme hépatique à son niveau assurent le maintien de la prothèse. Un exemplaire a été réalisé pour chaque lobe.相似文献
17.
R Mokni A Chakar F Bleiberg-Daniel JL Mahu PA Walravens P Chappuis J Navarro D Lemonnier 《Acta paediatrica (Oslo, Norway : 1992)》1993,82(6-7):539-543
Biochemical markers of nutritional status (albumin, transthyretin, insulin-like growth factor-I and zinc) were measured in slowly growing two- to five-year-old, low-income Parisian children whose weight-for-height or height-for-age z scores (WHZ or HAZ) were between — 1 and — 2 SD of the NCHS median. The results were compared to controls who were matched for age, sex, and ethnic origin with WHZ and HAZ between — 1 and + 2 SD. Mean serum levels of transthyretin, albumin and insulin-like growth factor-I and mean plasma zinc concentrations were significantly lower in the growth-impaired children than in the controls ( p = 0.002, p = 0.006, p = 0.015, and p = 0.035, respectively). While the height-retarded children had low mean serum insulin-like growth factor-I values, the weight-retarded subjects had decreased levels of albumin, transthyretin and zinc when compared to controls. Lower mean levels of nutritional markers in healthy, slowly growing children suggest that inadequate dietary intakes of zinc, protein and/or energy may result in marginal delays in weight and height gains. 相似文献
18.
In a retrospective study of 137 biopsy specimens of skin from 137 patients (69 men and 68 women) that had been obtained between 1972 and 1989 at our institution and that had perivascular and periappendageal lymphocytic infiltrates characteristic of those described as benign lymphocytic infiltrate (BLI), we determined the specificity of the histologic diagnosis and the correlation with clinical data. The final diagnoses, based on clinical and laboratory data and histologic findings, were BLI (59), possible BLI (7), lupus erythematosus (LE) (12), possible LE (7), procainamide-induced LE (1), insect bites (9), possible insect bites (3), polymorphous light eruption (4), lymphocytoma (4), urticaria (4), and indeterminate or miscellaneous diagnoses (27). BLI is a clinical and histologic syndrome that can be heterogeneous in origin. We recommend careful evaluation to exclude other disorders such as LE, polymorphous light eruption, lymphocytoma, and insect bites. Direct immunofluorescence microscopy and immunophenotypic studies may help distinguish BLI from LE. 相似文献
19.
Sherilyn Gross Karen Helm Jennifer J. Gruntmeir Wayne S. Stillman David W. Pyatt Richard D. Irons 《European journal of haematology》1997,59(5):318-326
Abstract: Our current understanding of human haematopoietic stem cell biology is based in part on the characterization of human CD34+ bone marrow cell differentiation in vitro. CD34 is highly expressed on early stem cells and haematopoietic progenitor cells with clonogenic potential and is gradually lost during differentiation and commitment. However, CD71 (transferrin receptor) is expressed at low levels on early stem cells and generally increases during haematopoietic progenitor cell proliferation. We reasoned that the combination of these surface markers would provide a useful framework for the simultaneous analysis of multiple lineage differentiation of CD34+ haematopoietic progenitor cells in liquid culture. In this report, we identify the phenotype of distinct subpopulations of myeloid, erythroid and lymphoid cells in liquid suspension culture using differential expression of CD34 vs. CD71 in combination with specific lineage markers. Freshly isolated human CD34+ bone marrow cells were introduced into suspension culture and monitored over a 6-d period using 3-colour flow cytometry. This is the first demonstration that differential expression of CD34 vs. CD71 can be used to simultaneously monitor differentiation of multiple haematopoietic cell lineages in liquid suspension culture, facilitating the study of cytokine-, drug- or chemical-induced alterations in haematopoietic progenitor cell differentiation in vitro. 相似文献
20.
Pied S; Voegtle D; Marussig M; Renia L; Miltgen F; Mazier D; Cazenave PA 《International immunology》1997,9(1):17-25
TCR V beta usage was examined in C57BL/6 mice infected with Plasmodium
yoelii. In addition to a polyclonal T cell activation, already described, a
superantigenic-like activity was observed during the acute infection. This
superantigenic activity induces a preferential deletion without prior
expansion of CD4+ and CD8+ T cells bearing the TCR V beta 9 segment. The
superantigen could be released by the parasite at different stages of its
development since the deletion of V beta 9+ T cells was observed in blood
and lymph nodes of mice infected either with sporozoites or with
erythrocytic stages. Injection of sporozoite or parasitized erythrocytes to
newborn mice led to a deletion and anergy of peripheral V beta 9+ T cells,
without affecting thymic T cell populations. These observations suggest
that the superantigen is released at very low concentrations during
parasite development. The role of such parasite superantigenic activity in
infectivity can be underlined by the observation that congenic BALB.D2
Mis1a mice lacking V beta 9 T cells are more susceptible to infection by P.
yoelii.
相似文献