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71.
Frl. L. Koopmann 《Journal of neurology》1926,95(1):165-167
Ohne Zusammenfassung 相似文献
72.
Dr. Hans Koopmann 《Virchows Archiv : an international journal of pathology》1920,228(1):319-344
Ohne ZusammenfassungAus dem pathologisch-anatomischen Institut des Allgemeinen Krankenhauses Barmbek. Prosektor Professor Dr. Fahr.Mit 8 Textabbildungen. 相似文献
73.
Scar formation: physiology and pathological states 总被引:3,自引:0,他引:3
74.
B Greenberg F Ahmann H Garewal C Koopmann S Coulthard H Berzes D Alberts D Shimm D Slymen 《Cancer》1987,59(11):1860-1865
The combination of cisplatin (100 mg/m2) and 5-fluorouracil (5-FU) by continuous infusion (1 g/m2/day for 5 days) has been reported to produce a high response rate as neoadjuvant therapy for advanced squamous cell head and neck cancer. We sought to improve the response rate by increasing the dose of 5-FU to 1.5 g/m2/day and 2.0 g/m2/day with allopurinol modulation to reduce toxicity. The overall response rate in the 30 patients who received three courses of chemotherapy was 100% with a 50% complete response (CR) rate. A 50% CR rate was observed in patients with T3 (six of 12) and N3 (four of eight) disease. Six patients (four with CR) did not complete subsequent treatment as planned. Seven of 11 (63.6%) chemotherapy complete responders and three of 12 (25%) partial responders (one lost to follow-up) who received all planned treatment are free of disease. The major toxicity encountered was stomatitis (severe in 32%) followed by leukopenia. The maximum tolerated dose of 5-FU in this combination with allopurinol protection was 1.5 g/m2/day. Cisplatin plus high dose 5-FU does not appear to be associated with a higher CR rate than that reported with conventional doses of 5-FU and is more toxic. 相似文献
75.
Tamara T. Koopmann BSc Marielle Alders PhD Roselie J. Jongbloed PhD Silvia Guerrero PhD Marcel M.A.M. Mannens PhD Arthur A.M. Wilde MD PhD Connie R. Bezzina PhD 《Heart rhythm》2006,3(1):52-55
BACKGROUND: The numerous mutations in the long QT syndrome (LQTS)-associated genes reported to date are point mutations or small insertions and deletions in coding regions or at splice junctions. OBJECTIVES: The purpose of this study was to determine the relative copy number of gene exons in a series of mutation-negative LQTS probands. METHODS: We used a quantitative multiplex approach because the polymerase chain reaction (PCR)-based exon-scanning methodologies routinely utilized in mutation analysis are unable to detect large genomic alterations. RESULTS: We identified the first large gene rearrangement consisting of a tandem duplication of 3.7 kb in KCNH2 responsible for LQTS in a Dutch family. This large duplication is expected to lead to nonfunctional or severely debilitated channels, thereby decreasing I(Kr). CONCLUSION: Our findings have implications for genetic testing in the approximately 30% of LQTS patients in whom conventional mutation screening fails to uncover a mutation. Analysis for large gene alterations such as the one described herein in routine genetic testing may provide a genetic diagnosis in a number of these patients. 相似文献
76.
77.
Zusammenfassung Es wird über einen Fall von isolierter produktiver Riesenzellen-myocarditis berichtet, der weder zur Tuberkulose noch zur Lues gerechnet werden kann, sondern der zu den vonKaufmann beschriebenen Fällen unbekannter Ursache gezählt werden muß.In Heft 5 des 8. Jahrgangs Der deutsche Militärarzt vom Mai 1943 erschien ein Aufsatz vonFischer Über eine eigenartige Form von Myocarditis und die Frage der Wehrdienstbeschädigung, auf den Herr Prof.Merkel mich aufmerksam machte. In dem FallFischer handelt es sich um einen meinem Fall histologisch sehr ähnlichen. Er ist dadurch ausgezeichnet, daß esFischer gelang, den Primärherd, die Eintrittsstelle des unspezifischen Erregers (Kokken), aufzufinden. 相似文献
78.
Angela M. Otto Nicole A. Kratochwil Hella Eggers Patrick J. Bednarski 《Journal of cancer research and clinical oncology》1995,121(1):31-38
The platinum(II) complex PtCl2(meso-6), which has the estrogenic ligandmeso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine (meso-6), has been reported to be an effective antitumor drug for estrogen-receptor(ER)-positive tumors in animal experiments. The goal of this study was to investigate whether the observed biological effects could be ascribed to the intact PtCl2(meso-6). Cultures of the ER-positive human breast cancer cell line MCF-7 were used as the in vitro test system. In culture medium containing 10% fetal calf serum, PtCl2(meso-6) had a half-life of about 2 h, as determined by HPLC analysis, and no PtCl2(meso-6) was detectable after 10 h. The Pt complex bound irreversibly to serum protein. After 30 min, the diamine ligand was found released, with a maximum conversion of about 35% at 24 h. At this time the culture medium still had estrogenic activity, i. e. it induced ER processing in the MCF-7 cells. This indicates that the estrogenic effect was elicited by the released diamine ligand. In contrast, the growth-inhibitory activity of the medium preincubated with PtCl2(meso-6) was lost at a rate similar to the rate of loss of PtCl2(meso-6) from the medium. This accords with the platinum complex being the main cytotoxic entity. When MCF-7 cells were incubated with PtCl2([3H]meso-6), no free Pt complex could be identified in cellular extracts, and most of the cell-associated radioactivity coeluted with meso-6 in HPLC analysis. After 12 h, only 1.4% of the total cellular platinum was bound to DNA, but no tritium label could be detected. In conclusion, diamine ligand is released from the Pt(II) complex and can account for the estrogenic effects so far ascribed to PtCl2(meso-6). 相似文献
79.
Christian Rønn Hansen Jørgen Johansen Eva Samsøe Elo Andersen Jørgen B.B. Petersen Kenneth Jensen Lisbeth J. Andersen Hella M.B. Sand Anders S. Bertelsen Cai Grau 《Radiotherapy and oncology》2018,126(1):43-47
Background and purpose
Defining margins around the Gross Tumour Volume (GTV) to create a Clinical Target Volume (CTV) for head and neck cancer radiotherapy has traditionally been based on presumed knowledge of anatomical routes of spread. However, using a concentric geometric expansion around the GTV may be more reproducible. The purpose of this study was to analyse the inter-observer consistency of geometric CTV delineation with adaptation for anatomical boundaries versus anatomically defined CTVs.Material and methods
Radiation oncologists at four Danish cancer centres delineated high, intermediate and elective dose CTVs (CTV1, CTV2 and CTV3, respectively) in a patient-case template (stage IV squamous cell carcinoma of the oropharynx), first using mainly anatomical margins (original standard) and then using concentric geometric expansion (new standard). Each centre made a dummy-run radiotherapy plan based on the delineated CTVs. The difference between the CTV contours and the radiotherapy plans was evaluated across the centres.Results
Anatomy-based contours were significantly more heterogenous and showed larger volume differences between centres than geometric margins. Dice similarity coefficient increased by 0.29 and mean surface distance decreased by 4 mm for CTV1. Use of consistent CTV volumes resulted in more consistent irradiated volumes between centres.Conclusion
Introduction of geometric margins resulted in more uniform CTV1 and CTV2 delineation. Geometric CTV expansion was easier, left less room for misinterpretation, and resulted in more uniform treatment plans with similar irradiated high and intermediate dose volumes across all centres. 相似文献80.
Intracranial complications of paranasal sinusitis constitute true surgical and medical emergencies. The charts of all patients (n = 649) admitted for acute or chronic sinusitis to the University of Minnesota Hospital and to the University of Michigan Medical Center during a 13-year period (1975 to 1988) were retrospectively reviewed to determine the incidence of complications. The clinical presentation, bacteriology, involved sinuses, influencing host factors, white blood cell count on presentation, length of hospitalization, and postinterventional complications are presented. Twenty-four patients with intracranial complications from paranasal sinusitis are studied for an incidence of 3.7%. Aggressive medical and semi-emergent surgical intervention are required to prevent excessive morbidity and/or mortality. Intracranial complications included subdural empyema, frontal lobe abscesses, intrahemispheric abscesses, cavernous and superior sagittal sinus thrombosis, and osteomyelitis. 相似文献