Synthesis of silver sulfide nanoparticles and their photodetector applications

Silver sulfide nanoparticles (Ag₂S NPs) are currently being explored as infrared active nanomaterials that can provide environmentally stable alternatives to heavy metals such as lead. In this paper, we describe the novel synthesis of Ag₂S NPs by using a sonochemistry method and the fabrication of photodetector devices through the integration of Ag₂S NPs atop a graphene sheet. We have also synthesized Li-doped Ag₂S NPs that exhibited a significantly enhanced photodetector sensitivity via their enhanced absorption ability in the UV-NIR region. First-principles calculations based on a density functional theory formalism indicated that Li-doping produced a dramatic enhancement of NIR photoluminescence of the Ag₂S NPs. Finally, high-performance photodetectors based on CVD graphene and Ag₂S NPs were demonstrated and investigated; the hybrid photodetectors based on Ag₂S NPs and Li-doped Ag₂S NPs exhibited a photoresponse of 2723.2 and 4146.0 A W⁻¹ respectively under a light exposure of 0.89 mW cm⁻² at 550 nm. Our novel approach represents a promising and effective method for the synthesis of eco-friendly semiconducting NPs for photoelectric devices.

Silver sulfide nanoparticles (Ag₂S NPs) are currently being explored as infrared active nanomaterials that can provide environmentally stable alternatives to heavy metals such as lead.     

执业药师在疾病管理中的作用

疾病管理可提高医疗的服务质量,减少不必要的医疗费用,执业药师在疾病管理尤其是慢病管理中可发挥重要作用。本文介绍了执业药师在疾病管理中的作用,并提出执业药师在慢病管理中的策略。     

Massive pulmonary embolism in a patient with nephrotic syndrome and single lung

Journal of Thrombosis and Thrombolysis - We present a novel case of a patient with nephrotic syndrome and previous left pneumonectomy who had a massive pulmonary embolism of his remnant right...     

Methotrexate use does not increase the prevalence of hepatic steatosis: a real-world retrospective nested case-control study

Clinical Rheumatology - We aimed to determine whether methotrexate (MTX) treatment in patients with rheumatoid arthritis (RA) leads to the development of non-alcoholic fatty liver (NAFL). Data were...     

高清胃镜下早期胃癌筛检策略的单中心前瞻性研究

目的　验证高清胃镜下早期胃癌筛检策略的效能。方法　前瞻性纳入2018年12月—2019年1月在解放军总医院第七医学中心行胃镜检查的849例年龄≥35岁的患者。在胃镜检查时,从未感染过幽门螺杆菌者对任何可疑病灶活检;溃疡型病灶于溃疡边缘活检;萎缩区域外,贲门部对白光下呈红色的病灶活检,非贲门部对具有清晰边界或白光下呈白色的病灶活检;萎缩区域内,隆起型病灶中具有清晰边界或顶部有不规则凹陷者活检,平坦/凹陷型病灶中边界不规则或窄带光下呈赭色者活检。此外,可对不符合上述策略但认为有必要活检的任何病灶进行活检。其后根据活检或手术病理,对胃癌高危患者进行胃镜随访,分析该策略对胃部早期肿瘤性病变的检出及漏诊情况,明确该策略的敏感度和阳性预测值。结果　共对548例患者的781处病灶进行了活检。在符合上述策略的327处病灶中,诊断上皮肿瘤性病灶16处（4.9%,16/327）,其中高级别肿瘤10处（3.1%,10/327）;而在不符合上述策略的454处病灶中,诊断上皮肿瘤性病灶仅1处（0.2%,1/454）,无高级别肿瘤。该筛检策略对胃上皮肿瘤性病灶和高级别肿瘤的阳性预测值均高于不符合策略而取活检者（4.9%比0.2%,χ2=19.49,P<0.001;3.1%比0,P<0.001）。共有146例（17.2%,146/849）患者接受胃镜随访,随访中发现2处黏膜内高级别肿瘤,符合筛检策略。该筛检策略在初次胃镜检查中检出了84.2%（16/19）的上皮肿瘤性病灶和83.3%（10/12）的高级别肿瘤。结论　高清胃镜下早期胃癌筛检策略可以高效地检出早期胃癌。     

一种野战卫生装备维修作业平台的研制

目的 :研制一种检修作业平台,实现野战卫生装备的快速检测与维修。方法 :以装配的某型野战卫生装备维修车为机体进行优化设计,引入维修PDCA循环模型,利用计算机技术自动分析装备的可维修性。结果:该平台可以自动优化选择维修方案,自动控制作业环境,装载布局合理。结论:该平台操作简单、方便实用,能够完成多种野战卫生装备的快速抢修和检测。     

Safety of endoscopic endonasal biopsy for the pituitary stalk-hypothalamic lesions

Purpose

The indications for and the optimal biopsy approach in pituitary stalk-hypothalamic (PsH) lesions are controversial. Biopsies through an endoscopic endonasal approach (EEA) for PsH lesions have often been considered to cause the infundibulo-tuberal syndrome. The purpose of this study was to analyze the surgical and endocrinological safety of EEA biopsies for PsH lesions.

Methods

A total of 39 consecutive patients who underwent an EEA biopsy between June 2011 and August 2020 in a single institute were retrospectively analyzed. The ophthalmological and endocrinological outcomes were assessed before and after surgery.

Results

PsH lesions were confirmed to be diverse pathological diagnoses, ranging from lymphocytic hypophysitis to diffuse midline glioma, and the most common pathologic diagnosis was a germinoma (18 patients, 46.2%). No patients developed visual deterioration after the biopsy. In patients without preoperative panhypopituitarism, 13 out of 28 patients (46.4%) developed new anterior pituitary hormonal deficiencies after the biopsy. When the tissue was collected from the stalk, the endocrinological deterioration rate was 100% (6 of 6 patients), while the rate was 31.8% (7 of 22 patients) when tissue could be harvested from an extra-stalk lesion. The rate of newly developed permanent diabetes insipidus after surgery was 40.9% (9 of 22 patients). The median surgery time was 125 min, and there was no postoperative CSF leakage or infections noted.

Conclusions

An EEA biopsy for PsH lesions is a safe and efficient surgical method unless the tissue is collected from the stalk.

     

Autoimmune cholangitis in a patient with thymoma

Autoimmune cholangitis is characterized biochemically by chronic cholestasis and histopathologically by chronic non-suppurative destructive cholangitis. It is associated with positive antinuclear antibody test and negative antimitochondrial antibody test results. Recently, we experienced a case of a 35-year-old woman with autoimmune cholangitis associated with thymoma who presented with pruritis, jaundice, chronic fatigue and anterior chest discomfort. Her laboratory examinations revealed marked increases in levels of serum alkaline phosphatase and gamma-glutamyl transpeptidase. In serological tests, antinuclear antibody was found, but antimitochondrial antibody was not. Liver biopsy findings were compatible with chronic non-suppurative destructive cholangitis. On computed tomography (CT) of the chest, a large anterior mediastinal mass was found. The mass was totally resected and the patient was treated with ursodeoxy cholic acid. Thereafter, her clinical symptoms improved and liver functions completely returned to the normal range. We describe here an uncommon association of autoimmune cholangitis with thymoma, which has not been reported previously in the English-written literature.