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91.
M. Hoshi M. Ieguchi S. Taguchi K. Sasaki K. Inoue K. Wakasa K. Takaoka 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2008,18(5):409-413
Liposarcoma is a one of the common soft tissue sarcomas, and is estimated to represent 16–18% of sarcomas in adults. According
to the World Health Organization, this tumor is mainly classified into five subtypes: well-differentiated, dedifferentiated,
myxoid/round, pleomorphic and mixed-type. Previous papers have reported that radiological information for liposarcoma is correlated
with the radiological and histopathological findings. In liposarcoma, when biphasic patterns composed of a lipogenic tumor
with a sarcomatous appearance are found on radiological examination of computed tomography and/or magnetic resonance imaging,
dedifferentiated liposarcoma, defined as a “malignant adipocytic neoplasm showing transition from atypical lipomatous tumor/well-differentiated
liposarcoma to non-lipogenic sarcoma of variable histological grade”, is usually considered. 相似文献
92.
93.
The surgical techniques and clinical results of quadrantectomy as a form of breast-conserving surgery are described. A quadrantectomy is a breast-conserving technique including wide resection and tumorectomy. A quadrantectomy is designed to remove an anatomic segment of breast tissue (duct-lobular system). It has the advantage of greater surgical curability than other conserving techniques in cases with ductal spread, because breast cancer arising in the terminal duct often spreads in the duct-lobular system. However, quadrantectomy poses some cosmetic problems due to the large volume of breast tissue excised. Additionally, quadrantectomy has failed to show better results in local recurrence rates compared with wide resection. Therefore quadrantectomy should be limited to breast cancer with segmental and wide ductal spread. It is important to determine the surgical technique that compromises between local curability and cosmetic results for each patient with breast cancer. 相似文献
94.
Tsunoda A Sada H Sugimoto T Kano N Kawana M Sasaki T Hashimoto H 《World journal of gastrointestinal surgery》2011,3(10):147-152
AIM:To compare hemorrhoidectomy with a bipolar electrothermal device or hemorrhoidectomy using an ultrasonically activated scalpel.METHODS:Sixty patients with grade Ⅲ or Ⅳ hemorrhoids were prospectively randomized to undergo closed hemorrhoidectomy assisted by bipolar diathermy(group 1) or hemorrhoidectomy with the ultrasonic scalpel(group 2).Operative data were recorded,and patients were followed at 1,3,and 6 wk to evaluate complications.Independent assessors were assigned to obtain postoperative pain scores,oral analgesic requirement and satisfaction scores.RESULTS:Reduced intraoperative blood loss median 0.9 mL(95% CI:0.8-3.7) vs 4.6 mL(95% CI:3.8-7.0),P = 0.001 and a short operating time median 16(95% CI:14.6-18.2) min vs 31(95% CI:28.1-35.3) min,P < 0.0001 was observed in group 1 compared with group 2.There was a trend towards lower postoperative pain scores on day 1 group 1 median 2(95% CI:1.8-3.5) vs group 2 median 3(95% CI:2.6-4.2),P = 0.135.Reduced oral analgesic requirement during postoperative 24 h after operation median 1(95% CI:0.4-0.9) tablet vs 1(95% CI:0.9-1.3) tablet,P = 0.006 was observed in group 1 compared with group 2.There was no difference between the two groups in the degree of patient satisfaction or number of postoperative complications.CONCLUSION:Bipolar diathermy hemorrhoidectomy is quick and bloodless and,although as painful as closed hemorrhoidectomy with the ultrasonic scalpel,is associated with a reduced analgesic requirement immediately after operation. 相似文献
95.
Kentaro Jujo Hiromichi Hamada Atsushi Iwakura Tina Thorne Haruki Sekiguchi Trevor Clarke Aiko Ito Sol Misener Toshikazu Tanaka Ekaterina Klyachko Koichi Kobayashi J?rn Tongers Jér?me Roncalli Yukio Tsurumi Nobuhisa Hagiwara Douglas W. Losordo 《Proceedings of the National Academy of Sciences of the United States of America》2010,107(24):11008-11013
We hypothesized that a small molecule CXCR4 antagonist, AMD3100 (AMD), could augment the mobilization of bone marrow (BM)-derived endothelial progenitor cells (EPCs), thereby enhancing neovascularization and functional recovery after myocardial infarction. Single-dose AMD injection administered after the onset of myocardial infarction increased circulating EPC counts and myocardial vascularity, reduced fibrosis, and improved cardiac function and survival. In mice transplanted with traceable BM cells, AMD increased BM-derived cell incorporation in the ischemic border zone. In contrast, continuous infusion of AMD, although increasing EPCs in the circulation, worsened outcome by blocking EPC incorporation. In addition to its effects as a CXCR4 antagonist, AMD also up-regulated VEGF and matrix metalloproteinase 9 (MMP-9) expression, and the benefits of AMD were not observed in the absence of MMP-9 expression in the BM. These findings suggest that AMD3100 preserves cardiac function after myocardial infarction by enhancing BM-EPC–mediated neovascularization, and that these benefits require MMP-9 expression in the BM, but not in the ischemic region. Our results indicate that AMD3100 could be a potentially useful therapy for the treatment of myocardial infarction. 相似文献
96.
Arita K Kondo T Sugita J Shigematsu A Shiratori S Wakasa K Yasumoto A Ibata M Shono Y Kikuchi M Goto H Takeda Y Takahata M Kato N Nishio M Ota S Tanaka J Imamura M 《International journal of hematology》2011,94(3):291-295
The prognosis of patients receiving allogeneic hematopoietic stem cell transplantation (HSCT) for refractory acute lymphoblastic leukemia (ALL) is very poor. To improve survival rates, we attempted to intensify the conditioning regimen with daunorubicin, vincristine, prednisolone, medium-dose etoposide, cyclophosphamide, and total body irradiation (DNR/VCR/PSL plus medium-dose VP/CY/TBI). Four patients in relapse or induction failure of B-precursor ALL without other complications underwent allogeneic HSCT. Initially, chemotherapy comprising DNR 60 mg/m(2) for 3 days, VCR 1.4 mg/m(2) for 1 day, and PSL 60 mg/m(2) for 3 days was administered, which was followed by medium-dose VP/CY/TBI; some modifications were made for individual patients. All patients achieved engraftment and complete remission after HSCT. Regimen-related toxicities were tolerable and no patient died within 100 days. Two patients were alive without disease on days 563 and 1,055. The third patient relapsed on day 951, while the fourth died on day 179 without disease. Our results indicate that intensified myeloablative HSCT should be considered for patients with refractory ALL. 相似文献
97.
Shinji Ueno Yusuke Seino Shihomi Hidaka Ryuya Maekawa Yuko Takano Michiyo Yamamoto Mika Hori Kana Yokota Atsushi Masuda Tatsuhito Himeno Shin Tsunekawa Hideki Kamiya Jiro Nakamura Hitoshi Kuwata Haruki Fujisawa Megumi Shibata Takeshi Takayanagi Yoshihisa Sugimura Daisuke Yabe Yoshitaka Hayashi Atsushi Suzuki 《Nutrients》2022,14(5)
(1) Background: Protein stimulates the secretion of glucagon (GCG), which can affect glucose metabolism. This study aimed to analyze the metabolic effect of a high-protein diet (HPD) in the presence or absence of proglucagon-derived peptides, including GCG and GLP-1. (2) Methods: The response to HPD feeding for 7 days was analyzed in mice deficient in proglucagon-derived peptides (GCGKO). (3) Results: In both control and GCGKO mice, food intake and body weight decreased with HPD and intestinal expression of Pepck increased. HPD also decreased plasma FGF21 levels, regardless of the presence of proglucagon-derived peptides. In control mice, HPD increased the hepatic expression of enzymes involved in amino acid metabolism without the elevation of plasma amino acid levels, except branched-chain amino acids. On the other hand, HPD-induced changes in the hepatic gene expression were attenuated in GCGKO mice, resulting in marked hyperaminoacidemia with lower blood glucose levels; the plasma concentration of glutamine exceeded that of glucose in HPD-fed GCGKO mice. (4) Conclusions: Increased plasma amino acid levels are a common feature in animal models with blocked GCG activity, and our results underscore that GCG plays essential roles in the homeostasis of amino acid metabolism in response to altered protein intake. 相似文献
98.
99.
Tohru Yorifuji M.D. Toru Momoi M.D. Takako Sonomura M.D. Chutaro Yamanaka M.D. Masayuki Kaji M.D. Haruki Mikawa M.D. Kyoko Kitagawa M.D. Hiroshi Ozasa M.D. Shunzo Tai M.D. Takahide Mori M.D. 《Pediatrics international》1989,31(1):85-89
In a patient with mos 45,X/46,XYnf, the diagnosis was confirmed with a Y chromosome-specific DNA probe, Y-190. The patient was a phenotypic female without Turner syndrome stigmata other than short stature. She showed some evidence of virilization and high serum testosterone. Her peripheral blood karyotype was mos 45,X/46X, +mar. Although this marker chromosome resembled a Y chromosome, there was no quinacrine bright region on its long arm. Southern blot analysis of her peripheral blood mononuclear cell DNA with Y-190 as a probe showed strong hybridization with this probe. Gonadectomy was performed, and bilateral gonadoblastomas were found. 相似文献
100.
Panax ginseng extract G-115 had anticomplementary and mitogenic activities. Incubation with artificial gastric juice slightly decreased the anticomplementary activity, whereas incubation with artificial intestinal juice or with artificial gastric juice followed by artificial intestinal juice slightly increased the activity. Incubations with artificial gastric and intestinal juices slightly decreased mitogenic activity similar to that with water. The G-115 was fractionated in order to characterize the active substances for anticomplementary and mitogenic activities. The most potent anticomplementary activity was observed in the crude polysaccharide fraction, G-115G, whereas the water-soluble dialysable fraction, G-115E showed the most potent mitogenic activity. Although pronase digestion did not change the anticomplementary activity of G-115G, G-115G decreased the anticomplementary activity after the treatments with periodate and endo-polygalacturonase indicating that a carbohydrate moiety containing polygalacturonan may contribute to the activity. G-115G was further purified by precipitation with cetyltrimethylammonium bromide, anion-exchange chromatography on DEAE-Sepharose and gel filtration on Sepharose CL-4B, and major potent anticomplementary polysaccharide, G-115I1-IIa-2-3 was obtained. G-115I1-IIa-2-3 was homogeneous, and its molecular weight was estimated to be 3.68 × 105. G-115I1-IIa-2-3 consisted mainly of arabinose, galactose and glucose in addition to small amounts of galacturonic acid, glucuronic acid and rhamnose. 相似文献