全文获取类型
收费全文 | 450篇 |
免费 | 47篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 20篇 |
妇产科学 | 2篇 |
基础医学 | 54篇 |
口腔科学 | 17篇 |
临床医学 | 50篇 |
内科学 | 108篇 |
皮肤病学 | 9篇 |
神经病学 | 42篇 |
特种医学 | 98篇 |
外科学 | 29篇 |
综合类 | 17篇 |
预防医学 | 27篇 |
眼科学 | 1篇 |
药学 | 29篇 |
肿瘤学 | 10篇 |
出版年
2022年 | 5篇 |
2018年 | 4篇 |
2016年 | 6篇 |
2015年 | 5篇 |
2014年 | 15篇 |
2013年 | 15篇 |
2012年 | 6篇 |
2011年 | 6篇 |
2010年 | 15篇 |
2009年 | 14篇 |
2008年 | 7篇 |
2007年 | 21篇 |
2006年 | 11篇 |
2005年 | 13篇 |
2004年 | 7篇 |
2003年 | 5篇 |
2002年 | 12篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 8篇 |
1998年 | 24篇 |
1997年 | 17篇 |
1996年 | 15篇 |
1995年 | 20篇 |
1994年 | 14篇 |
1993年 | 14篇 |
1992年 | 8篇 |
1991年 | 6篇 |
1990年 | 8篇 |
1989年 | 20篇 |
1988年 | 16篇 |
1987年 | 20篇 |
1986年 | 16篇 |
1985年 | 15篇 |
1984年 | 5篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1977年 | 11篇 |
1976年 | 10篇 |
1975年 | 11篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1972年 | 6篇 |
1971年 | 3篇 |
1970年 | 5篇 |
1969年 | 3篇 |
排序方式: 共有516条查询结果,搜索用时 13 毫秒
21.
Lipsky PE van der Heijde DM St Clair EW Furst DE Breedveld FC Kalden JR Smolen JS Weisman M Emery P Feldmann M Harriman GR Maini RN;Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group 《The New England journal of medicine》2000,343(22):1594-1602
BACKGROUND: Neutralization of tumor necrosis factor a (TNF-alpha) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known. METHODS: We treated 428 patients who had active rheumatoid arthritis despite methotrexate therapy with placebo or infliximab, a chimeric monoclonal antibody against TNF-alpha, in intravenous doses of 3 or 10 mg per kilogram of body weight every 4 or 8 weeks in combination with oral methotrexate for 54 weeks. We assessed clinical responses with use of the criteria of the American College of Rheumatology, the quality of life with a health-status questionnaire, and the effect on joint damage radiographically. RESULTS: The combination of infliximab and methotrexate was well tolerated and resulted in a sustained reduction in the symptoms and signs of rheumatoid arthritis that was significantly greater than the reduction associated with methotrexate therapy alone (clinical response, 51.8 percent vs. 17.0 percent; P<0.001). The quality of life was also significantly better with infliximab plus methotrexate than with methotrexate alone. Radiographic evidence of joint damage increased in the group given methotrexate, but not in the groups given infliximab and methotrexate (mean change in radiographic score, 7.0 vs. 0.6, P<0.001). Radiographic evidence of progression of joint damage was absent in infliximab-treated patients whether or not they had a clinical response. CONCLUSIONS: In patients with persistently active rheumatoid arthritis despite methotrexate therapy, repeated doses of infliximab in combination with methotrexate provided clinical benefit and halted the progression of joint damage. 相似文献
22.
GL Marseglia S Savasta A Ravelli TM Gaino GR Burgio 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(9):1086-1088
We report the case of a 9-year-old boy with a spinal cord meningioma whose only manifestations were recurrent episodes of chest pain lasting for 2 years. This case shows that spinal cord meningioma should be considered among the possible causative factors of chronic chest pain in childhood. Chest pain, meningioma, spinal tumors 相似文献
23.
Oleksiy V Klymenko David J Gavaghan Kathryn E Harriman Richard G Compton 《Journal of electroanalytical chemistry (Lausanne, Switzerland)》2002,531(1):25-31
A finite element approach for numerical simulation of linear sweep voltammetry at the wall tube electrode is presented. Working curves and surfaces are computed and reported which permit the analysis of reversible, quasi-reversible and irreversible voltammograms for all voltage scan rates. 相似文献
24.
25.
26.
Indirect induction of prophage λ was thought to be limited to ultraviolet-irradiated DNA. Results presented here show that phage P1 that has sustained gamma irradiation and 32P decay is as effective as ultraviolet-irradiated P1 in indirectly inducing prophage λ. 相似文献
27.
Background
India accounts for approximately 10 million orthopaedically handicapped children and adults with limb deformity. Ilizarov ring fixator could treat most of these deformities.Methods
Twenty cases of deformities of lower limb managed with Ilizarov technique during period between March 2001 and February 2003 were studied.Results
55% were in the age group of 11-30 years. Out of the 20 cases studied, 6 were congenital talipes equino varus, 8 were fixed flexion deformity of knee, 4 were equines deformity of the ankle and 2 were malunited fracture shaft of tibia.4 patients who had recurrence were operated for fixed flexion deformity of the knee. The main complication encountered was pin tract infection, which was seen in 15(75%) cases. In 16(80%) cases, the results were excellent with no recurrence of deformity and patients were able to walk independently. In 4 (20%) cases, recurrence was mild to moderate (10 to 20) but all of them were able to ambulate idependently and carry out their routine activities.Conclusion
Ilizarov ring fixator is a superior compared to conventional methods for correction of deformities of lower limb.Key Words: Ilizarov method, Ligamentotaxis, Distraction 相似文献28.
Buck JM Como-Sabetti K Harriman KH Danila RN Boxrud DJ Glennen A Lynfield R 《Emerging infectious diseases》2005,11(10):1532-1538
We compared characteristics of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) skin and soft tissue infections (SSTIs) and CA-MRSA invasive disease identified in Minnesota from 2000 through 2003. A total of 586 patients with SSTIs and 65 patients with invasive disease were identified. Patients with invasive disease were more likely to be smokers (p = 0.03), and report a history of immunosuppressive therapy (p = 0.03), emphysema (p = 0.011), or injection drug use (p = 0.020) than were SSTI patients. Invasive disease isolates were less likely to be susceptible to ciprofloxacin (p = 0.002) and clindamycin (p = 0.001) and more likely to have healthcare-associated pulsed-field gel electrophoresis subtypes than SSTI isolates (p<0.001). Patients with invasive disease may have had healthcare exposures that put them at risk of acquiring healthcare-associated MRSA and which were not exclusion criteria in the CA-MRSA case definition. Continued surveillance of MRSA is needed to better characterize CA-MRSA infections. 相似文献
29.
Background
There is paucity of literature describing complex elbow trauma in the pediatric population. We described a case of an uncommon pediatric elbow injury comprised of lateral condyle fracture associated with posterolateral dislocation of elbow. 相似文献30.