The role of hypertension-related gene in aortic vascular smooth muscle cells from mice and rats

目的　研究高血压相关基因 (HRG 1)在心血管病发病中的作用。方法　用RT PCR和Northernblot分析HRG 1的表达。用3 H TdR掺入和组织学方法检测血管平滑肌细胞 (VSMC)的增殖。结果　Northernblot分析显示 ,HRG 1mRNA不仅可在VSMC中表达 ,亦可在大鼠多种组织中表达 (心、脑、肺、肾和肝 )。此外 ,在SHR大鼠的心、脑、肾和肝组织的HRG 1基因表达均明显低于正常WKY大鼠。半定量RT PCR和组织学分析表明 ,ApoE敲除小鼠和再狭窄动物模型的HRG 1mRNA表达减少 ,并且均可见到新生内膜形成。刺激VSMC增殖的ET ,AII和IL 1可减少VSMCHRG 1mRNA的表达。ANF ,CGRP和Adm可抑制VSMC增殖 ,增加HRG 1mRNA表达。这些作用能被相应的阻断剂或抗体所阻断或抑制。结论　HRG 1是一种与VSMC增殖相关的基因 ,它在动脉粥样硬化 ,再狭窄和高血压等心血管疾病中可能具有重要作用。     

Ratings of profile attractiveness after functional appliance treatment.

The aim of this study was to determine the change in profile attractiveness in children with Class II Division 1 malocclusion after 18 months' treatment with functional appliances. Changes in profile attractiveness were assessed by panels of art students, dental students, and parents of orthodontic patients. Each panel consisted of an equal number of male and female raters. The raters first decided whether the initial or 18-month profile silhouette was more attractive, and then scored the degree to which it was more attractive on an unmarked visual analog scale. There were no significant differences between either male and female raters or among panels in their assessments of the change in profile attractiveness in the whole sample. Neither were there significant differences between the change in profile attractiveness of the untreated subjects and the subjects treated with either Fr?nkel function regulators or Harvold activators. It is concluded that treatment with functional appliances does not lead to more attractive profiles than nontreatment.     

Spontaneous intralesional haemorrhage in dysembryoplastic neuroepithelial tumours: a series of five cases

Five patients with dysembryoplasticneuroepithelial tumour (DNT) showing extensive secondaryhaemorrhage, a finding not previously associated with these neoplasms,are described. The clinical presentations, neuroimaging findings, andhistopathological features of these patients are reviewed. Onepatient, a previously asymptomatic 12 year old girl, presented with anacute intracerebral haemorrhage into a DNT. A further four young adultswith histories of intractable partial and generalised seizures datingfrom childhood showed significant chronic haemorrhages within DNT, theMRI appearances in one patient giving a false impression of acavernoma. Histopathology disclosed vascular abnormalities within thesetumours which, together with other factors discussed, may havepredisposed these tumours to haemorrhage.

     

Very old patients admitted to intensive care in Australia and New Zealand: a multi-centre cohort analysis

Introduction  

Older age is associated with higher prevalence of chronic illness and functional impairment, contributing to an increased rate of hospitalization and admission to intensive care. The primary objective was to evaluate the rate, characteristics and outcomes of very old (age ≥ 80 years) patients admitted to intensive care units (ICUs).