Pulsatile ocular blood flow in patients with asymmetric internal carotid artery stenosis

Background: The pulsatile ocular blood flow (POBF) of patients with asymmetric internal carotid artery (ICA) stenosis was measured bilaterally. The purpose of this study was to investigate the sensitivity of POBF assessments in screening for ICA stenosis. Methods: Seventeen subjects with asymmetric ICA stenosis confirmed with carotid duplex ultrasound were recruited. The diagnoses of ICA stenosis were categorised into less than50 per cent, 50 to 69 per cent and 70 per cent or greater. Their POBF and ocular dimensions were measured after local anaesthesia. Twenty‐three normal healthy subjects were recruited as the control. All of the subjects had an inter‐ocular axial length difference of less than one millimetre. Results: There were 14 males and three females in the patient group with a median age of 74 years. Fourteen patients had reduced POBF to the eye ipsilateral on the side with greater ICA stenosis. The reduction in POBF ranged from 3.1 to 49.2 per cent. Two patients had reduced POBF contralateral to the side with greater ICA stenosis. One patient had similar POBF between the eyes. The control group included six males and 17 females with a median age of 65 years. The difference in their POBF between the eyes ranged from 0.3 to 13.0 per cent. Conclusions: Stenosis of the internal carotid artery was found to reduce the POBF ipsilateral to the side with greater stenosis. The overlap in the difference in inter‐ocular POBF between the patient and control groups led to a low sensitivity (calculated as 41.2 per cent) for screening ICA stenosis from an assessment of POBF. Therefore, POBF assessment is not a good diagnostic tool for screening for ICA stenosis.     

Prevention of microaggregation in stored blood (author's transl)]

Microembolism is still a feared complication during and after blood transfusions. Up to now they could only be diminished by special filter systems. In spite of much research it has not been possible as yet to fine adequate remedies for the preservation of blood cells and for the decrease of aggregation in stored blood. As foregoing studies have shown the inhibition of aggregation is combined with a considerable impairment or even loss of platelet function. In these clinical experiments, however, it has been shown, that aggregations in stored blood are significantly stunted by early addition of Aprotinin. It is clinically important, that no inhibition of platelet function occured.     

Experimentelle Untersuchungen über Resorption und Abbau von Benzpyren

Zusammenfassung Untersucht wurden die Resorptions- und Abbauvorgänge nach intraperitonealer Injektion von Benzpyren in verschiedenen Lösungsmitteln bei Ratten und Goldhamstern. Es fand sich eine deutliche Unterschiedlichkeit der Verweildauer des Benzpyrens abhängig vom Lösungsmittel und erhebliche Unterschiede der Abbauleistung bei den beiden Tierarten. Die Bedeutung der einzelnen Faktoren für die cancerogene Wirkung wird diskutiert.

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Experimental studies of the absorption and decomposition of benzpyrene

Summary The absorption and catabolism of benzpyrene in different solvents in rats and golden hamsters was investigated after intraperitoneal injection. A significant difference was found for the stay-period of benzpyrene depending on solvents as well as for the catabolism of animal species examined. The importance of particular factors for the carcinogenic activity is discussed.