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991.
Rebecka Peebles Jenny L Wilson Iris F Litt Kristina K Hardy James D Lock Julia R Mann Dina LG Borzekowski 《Journal of medical Internet research》2012,14(5)
Background
Much concern has been raised over pro-eating disorder (pro-ED) website communities, but little quantitative research has been conducted on these websites and their users.Objective
To examine associations between levels of pro-ED website usage, disordered eating behaviors, and quality of life.Methods
We conducted a cross-sectional, Internet-based survey of adult pro-ED website users. Main outcomes were Eating Disorder Examination Questionnaire (EDE-Q) and Eating Disorder Quality of Life (EDQOL) scores.Results
We included responses from 1291 participants; 1254 (97.13%) participants were female. Participants had an average age of 22.0 years and a mean body mass index of 22.1 kg/m2; 24.83% (296/1192) were underweight; 20.89% (249/1192) were overweight or obese. Over 70% of participants had purged, binged, or used laxatives to control their weight; only 12.91% (163/1263) were in treatment. Mean EDE-Q scores were above the 90th percentile and mean EDQOL scores were in the severely impaired range. When compared with moderate and light usage, heavy pro-ED website usage was associated with higher EDE-Q global (4.89 vs 4.56 for medium and 4.0 for light usage, P < .001) and EDQOL total scores (1.64 vs 1.45 for medium and 1.25 for light usage, P < .001), and more extreme weight loss behaviors and harmful post-website usage activities. In a multivariate model, the level of pro-ED website usage remained a significant predictor of EDE-Q scores.Conclusions
Pro-ED website visitors reported many disordered eating behaviors, although few had been treated. Heavy users reported poorer quality of life and more disordered eating behaviors. 相似文献992.
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Wang H Jones J Turner T He QP Hardy S Grizzle WE Welch DR Yates C 《The American journal of pathology》2012,180(3):1170-1178
For men in the United States, prostate cancer (PCa) is the most frequent malignancy and the second leading cause of cancer mortality. The metastatic spread of PCa is responsible for most deaths related to PCa. Although KISS1 functions as a metastasis suppressor in various cancers, its expression levels and functions in PCa development and progression remain undetermined. The goals of this study were to correlate the expression levels of KISS1 in PCas with clinicopathologic characteristics and to assess the biological relevance of KISS1 to the viability and motility of PCa cells. Strong KISS1 staining was detected in benign prostate tissues, but the staining was weaker in primary and metastatic PCas (both P < 0.001, t-test). Furthermore, the low expression levels of KISS1 in PCas correlated with clinical stage (P < 0.01) and with KISS1R expression (P < 0.001). Overexpression of full-length KISS1 in low KISS1-expressing PC-3M cells, but not KFMΔSS, which lacks the secretion signal sequence, induced re-sensitization of cells to anoikis, although it had no effect on either cell proliferation or apoptosis. Overexpression of KISS1 also suppressed steps in the metastatic cascade, including motility and invasiveness. Moreover, cells overexpressing KISS1 were found to enhance chemosensitivity to paclitaxel. Collectively, our data suggest that KISS1 functions as a metastasis suppressor in PCas and may serve as a useful biomarker as well as a therapeutic target for aggressive PCas. 相似文献
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Stephen R. Thom MD PhD Tatyana N. Milovanova MD PhD Ming Yang MD Veena M. Bhopale PhD Elena M. Sorokina PhD Günalp Uzun MD D. Scot Malay DPM MSCE Michael A. Troiano DPM Kevin R. Hardy MD David S. Lambert MD Christopher J. Logue MD David J. Margolis MD PhD 《Wound repair and regeneration》2011,19(2):149-161
Diabetic patients undergoing hyperbaric oxygen therapies (HBO2T) for refractory lower extremity neuropathic ulcers exhibit more than a twofold elevation (p=0.004) in circulating stem cells after treatments and the post‐HBO2T CD34+ cell population contains two‐ to threefold higher levels of hypoxia inducible factors‐1, ‐2, and ‐3, as well as thioredoxin‐1 (p<0.003), than cells present in blood before HBO2T. Skin margins obtained from 2‐day‐old abdominal wounds exhibit higher expression of CD133, CD34, hypoxia inducible factor‐1, and Trx‐1 vs. margins from refractory lower extremity wounds and expression of these proteins in all wounds is increased due to HBO2T (p<0.003). HBO2T is known to mobilize bone marrow stem cells by stimulating nitric oxide synthase. We found that nitric oxide synthase activity is acutely increased in patients' platelets following HBO2T and remains elevated for at least 20 hours. We conclude that HBO2T stimulates vasculogenic stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds. 相似文献
998.
Hardy MA 《Foot & ankle specialist》2011,4(2):120-123
The majority of orthopaedic venous thromboembolism (VTE) literature involves major orthopaedic surgery, which has distinct differences in comparison with foot and ankle surgery. Despite the current evidence-based medicine advocating against routine prophylaxis, confusion remains around who should be prophylaxed and with what modality. Clearly, larger prospective studies are needed to determine those individuals who require prophylaxis for the prevention of venous thromboembolic events following foot and ankle surgery. 相似文献
999.
Hardy S Eichelberger M Griffiths E Weir JP Wood D Alfonso C 《Influenza and other respiratory viruses》2011,5(6):438-442
Please cite this paper as: Hardy et al. (2011) Confronting the next pandemic—Workshop on lessons learned from potency testing of pandemic (H1N1) 2009 influenza vaccines and considerations for future potency tests, Ottawa, Canada, July 27–29, 2010. Influenza and Other Respiratory Viruses 5(6), 438–442. 相似文献
1000.
Hardy TA Garsia RJ Halmagyi GM Lewis SJ Harrisberg B Fulham MJ Barnett MH 《Journal of the neurological sciences》2011,302(1-2):126-128
Susac's syndrome is the clinical triad of encephalopathy, branch retinal artery occlusions and sensorineural hearing loss (Susac 1994) [1]. It occurs predominantly in young females and is believed to be an immune-mediated endotheliopathy of small vessels of the brain, retina and cochlea (Neumayer et al. 2009) [2]. Early, aggressive, and sustained immunosuppressive therapy has been recommended for Susac's syndrome and anecdotal evidence has suggested a therapeutic role for monoclonal antibodies (Rennebohm et al. 2008, Lee and Amezcua 2009) [3,4]. We report a case of Susac's syndrome in which the patient improved immediately after tumour necrosis factor (TNF) inhibition with the monoclonal antibody, infliximab. 相似文献