全文获取类型
收费全文 | 34312篇 |
免费 | 1884篇 |
国内免费 | 150篇 |
专业分类
耳鼻咽喉 | 447篇 |
儿科学 | 790篇 |
妇产科学 | 612篇 |
基础医学 | 6443篇 |
口腔科学 | 767篇 |
临床医学 | 2725篇 |
内科学 | 6455篇 |
皮肤病学 | 863篇 |
神经病学 | 3511篇 |
特种医学 | 1477篇 |
外科学 | 4899篇 |
综合类 | 154篇 |
一般理论 | 14篇 |
预防医学 | 1717篇 |
眼科学 | 738篇 |
药学 | 2361篇 |
中国医学 | 22篇 |
肿瘤学 | 2351篇 |
出版年
2022年 | 173篇 |
2021年 | 381篇 |
2020年 | 315篇 |
2019年 | 528篇 |
2018年 | 611篇 |
2017年 | 482篇 |
2016年 | 618篇 |
2015年 | 690篇 |
2014年 | 828篇 |
2013年 | 1225篇 |
2012年 | 1697篇 |
2011年 | 1818篇 |
2010年 | 1226篇 |
2009年 | 1181篇 |
2008年 | 1944篇 |
2007年 | 1991篇 |
2006年 | 1848篇 |
2005年 | 1963篇 |
2004年 | 1848篇 |
2003年 | 1814篇 |
2002年 | 1883篇 |
2001年 | 373篇 |
2000年 | 290篇 |
1999年 | 410篇 |
1998年 | 517篇 |
1997年 | 429篇 |
1996年 | 386篇 |
1995年 | 348篇 |
1994年 | 300篇 |
1993年 | 272篇 |
1992年 | 228篇 |
1991年 | 221篇 |
1990年 | 181篇 |
1989年 | 175篇 |
1988年 | 177篇 |
1987年 | 142篇 |
1985年 | 159篇 |
1984年 | 185篇 |
1983年 | 168篇 |
1982年 | 200篇 |
1981年 | 173篇 |
1933年 | 170篇 |
1932年 | 186篇 |
1931年 | 167篇 |
1930年 | 172篇 |
1929年 | 147篇 |
1928年 | 164篇 |
1927年 | 144篇 |
1926年 | 158篇 |
1925年 | 139篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Hans D de Boer Jan van Egmond Jacques J Driessen Leo HD Booij 《Neuropsychiatric Disease and Treatment》2007,3(5):539-544
Steroidal neuromuscular blocking agents (NMBAs), such as rocuronium, are widely used in clinical anesthesia and emergency medicine to facilitate endotracheal intubation and artificial ventilation and to allow surgical access to body cavities. Reversal of neuromuscular blockade is important for the acceleration of patient recovery and prevention of postoperative residual neuromuscular blockade and reduces the incidence of severe morbidity and mortality associated with anesthesia management. Sugammadex is the first selective relaxant binding agent (SRBA) and has been designed to reverse the steroidal neuromuscular blocking drug rocuronium. Encapsulation of the rocuronium molecule by sugammadex results in a rapid decrease in free rocuronium in the plasma and subsequently at the nicotinic receptor at the motor endplate. After encapsulation, rocuronium is not available to bind to the nicotinic receptor in the neuromuscular junction. This promotes the liberation of acetylcholine receptors, and muscle activity reappears. This new concept of reversal of neuromuscular block induced by rocuronium (or vecuronium) led to impressive results in animal and phase 1 and 2 studies. Sugammadex is currently in phase 3 clinical studies and may be commercially available by 2008. 相似文献
22.
Marc Bischof MD Jürgen Debus Klaus Herfarth Thomas Muley Jutta Kappes Konstantina Storz Hans Hoffmann 《Strahlentherapie und Onkologie》2007,183(12):679-684
PURPOSE: To analyze the effectiveness of surgery and chemotherapy with or without radiotherapy in the management of limited small cell lung cancer (LSCLC) in stages I and II. PATIENTS AND METHODS: 39 patients (median age 62 years) with LSCLC in stages pT1 or pT2 and pN0 or pN1 (stages IA-IIB) who had a tumor resection and systematic lymph node dissection were reviewed retrospectively. The median follow-up period was 29 months. 35 patients (90%) received a median of four cycles of a platinum-containing chemotherapy postoperatively. 16 patients (41%) received an adjuvant thoracic radiotherapy (TRT, median 50 Gy); 21 patients (54%) received a prophylactic cranial irradiation (PCI, median 30 Gy). RESULTS: The median overall survival for all patients was 47 months, resulting in actuarial 1-, 3-, and 5-year survival rates of 97%, 58%, and 49%, respectively. Distant metastases were found in 13 patients (33%) after a median of 16 months. Patients who received an adjuvant TRT showed a trend toward improved thoracic recurrence-free survival (p = 0.06) and improved overall survival (p = 0.07) compared to those treated with surgery and chemotherapy only. Brain metastasis-free survival (p = 0.01) and overall survival (p = 0.01) were improved significantly in patients who received a PCI. CONCLUSION: Surgical tumor resection may be considered for carefully selected patients. Adjuvant chemotherapy and PCI are recommended for all patients. Adjuvant TRT is currently used in patients with positive lymph nodes (pN1), because the probability of a subclinical involvement of the mediastinal lymphatic system appears to be increased in these patients. 相似文献
23.
The reconstruction of a part of the body that has lost or inhibited function has been the most important aspect of reconstructive surgery in the past. Because of the existence of better techniques and the patient's wish for social reintegration, the plastic surgeon today is forced to consider the aesthetic results of his work more than in the past. Sometimes microsurgical procedures in reconstructive surgery are the only chance for the patient to be healed or palliated. Experience with more than 350 free tissue transfers gave us the opportunity to estimate the value of a donor flap with respect to the requirements of the receiving site. To satisfy the high aesthetic demands in these cases, it was necessary for the right place and shape the flap to fit as closely as possible, even if further corrections were necessary to achieve a satisfactory result. The transfer of latissimus dorsi and radial forearm flaps to the face and lower leg is discussed in cases of tumorus diseases and severe injuries of young and old patients.Presented to the IXth Congress of the International Society of Aesthetic Plastic Surgery, New York, October 13, 1987 相似文献
24.
Background
The fibromyalgia syndrome (FMS) is suggested to be a manifestation of depression or affective spectrum disorder. We measured the cognitive style of patients with FMS to assess personality styles in 44 patients with fibromyalgia syndrome (FMS) by comparing them with 43 patients with major depressive disorder (MDD) and 41 healthy controls (HC). 相似文献25.
Ayman Agha Gabriel Glockzin Matthias Woenckhaus Wolfgang Dietmaier Igors Iesalnieks Hans J. Schlitt 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2007,392(6):671-677
Background Insular thyroid carcinoma was described as a tumor with aggressive behavior, and patients usually present themselves with
an advanced tumor stage. Whether the insular component is an independent factor for poor prognosis remains unclear. Therefore,
in the present study, we compared the survival of patients with advanced insular, follicular, and papillary thyroid cancer.
Materials and methods The clinical behavior of tumors in three groups of patients with T4 thyroid carcinoma—8 patients with insular, 11 patients
with follicular, and 21 patients with papillary thyroid carcinomas—was compared. Disease-free survival and disease-specific
death were analyzed statistically. Cox regression analysis was used to evaluate the influence of histotype and other prognostic
factors.
Results At 3 years, survival was 37.5% (mean 26 months) among patients with insular thyroid carcinoma, 80% (mean 59 months) among
those with follicular, and 89% (mean 126 months) among those with papillary thyroid carcinomas (p = 0.007). Disease-free survival in patients without initial distant metastasis was worst in patients with insular thyroid
carcinoma (20%) compared to those with follicular (75%) and those with papillary thyroid carcinomas (71%).
Conclusion Patients with advanced insular thyroid carcinoma have a poorer outcome in comparison to patients with similar advanced stage
who have follicular or papillary thyroid carcinoma. 相似文献
26.
27.
Jürgen Hoyer Sylvia Helbig Hans‐Ulrich Wittchen 《Clinical psychology & psychotherapy》2006,13(6):414-421
The present survey assessed consumer satisfaction of patients having undergone psychotherapy for depression as well as service characteristics including treatment access, communication of diagnosis and treatment rationale, quality assurance and adverse events. The study was conducted in the form of a 15‐item questionnaire that was published in one of Germany's leading health magazines. 473 persons responded (81.5% women, age range 17–83). 49.8% of the respondents reported substantial or reasonable improvement; two out of three patients stated they had been satisfied with their therapy. Improvement and satisfaction were greater in those patients who had been informed about diagnosis and treatment; they were lower when unpleasant experiences were reported. Methodological restrictions of the study are outlined and hypotheses about potential strengths and deficits in the delivery of psychotherapy for depression in Germany are proposed. Copyright © 2006 John Wiley & Sons, Ltd. 相似文献
28.
29.
30.