全文获取类型
收费全文 | 1404篇 |
免费 | 78篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 20篇 |
妇产科学 | 9篇 |
基础医学 | 182篇 |
口腔科学 | 11篇 |
临床医学 | 157篇 |
内科学 | 353篇 |
皮肤病学 | 28篇 |
神经病学 | 91篇 |
特种医学 | 86篇 |
外科学 | 249篇 |
综合类 | 9篇 |
一般理论 | 1篇 |
预防医学 | 62篇 |
眼科学 | 26篇 |
药学 | 69篇 |
中国医学 | 1篇 |
肿瘤学 | 120篇 |
出版年
2022年 | 10篇 |
2021年 | 21篇 |
2020年 | 17篇 |
2019年 | 17篇 |
2018年 | 22篇 |
2017年 | 19篇 |
2016年 | 32篇 |
2015年 | 37篇 |
2014年 | 48篇 |
2013年 | 46篇 |
2012年 | 102篇 |
2011年 | 107篇 |
2010年 | 79篇 |
2009年 | 53篇 |
2008年 | 101篇 |
2007年 | 91篇 |
2006年 | 79篇 |
2005年 | 86篇 |
2004年 | 75篇 |
2003年 | 64篇 |
2002年 | 56篇 |
2001年 | 15篇 |
2000年 | 23篇 |
1999年 | 14篇 |
1998年 | 16篇 |
1997年 | 10篇 |
1996年 | 7篇 |
1994年 | 6篇 |
1992年 | 17篇 |
1991年 | 13篇 |
1990年 | 14篇 |
1989年 | 14篇 |
1988年 | 11篇 |
1987年 | 11篇 |
1986年 | 11篇 |
1985年 | 9篇 |
1984年 | 9篇 |
1983年 | 7篇 |
1980年 | 4篇 |
1979年 | 8篇 |
1978年 | 10篇 |
1974年 | 6篇 |
1973年 | 4篇 |
1972年 | 7篇 |
1971年 | 4篇 |
1970年 | 5篇 |
1967年 | 5篇 |
1966年 | 5篇 |
1965年 | 4篇 |
1949年 | 7篇 |
排序方式: 共有1482条查询结果,搜索用时 15 毫秒
101.
Dissociations among functional subsystems governing melody recognition after right-hemisphere damage
This study describes an amateur musician, KB, who became amusic following a right-hemisphere stroke. A series of assessments conducted post-stroke revealed that KB functioned in the normal range for most verbal skills. However, compared with controls matched in age and music training, KB showed severe loss of pitch and rhythmic processing abilities. His ability to recognise and identify familiar instrumental melodies was also lost. Despite these deficits, KB performed remarkably well when asked to recognise and identify familiar song melodies presented without accompanying lyrics. This dissociation between the ability to recognise/identify song vs. instrumental melodies was replicated across different sets of musical materials, including newly learned melodies. Analyses of the acoustical and musical features of song and instrumental melodies discounted an explanation of the dissociation based on these features alone. Rather, the results suggest a functional dissociation resulting from a focal brain lesion. We propose that, in the case of song melodies, there remains sufficient activation in KB's melody analysis system to coactivate an intact representation of both associative information and the lyrics in the speech lexicon, making recognition and identification possible. In the case of instrumental melodies, no such associative processes exist; thus recognition and identification do not occur. 相似文献
102.
Steinke K Gananadha S King J Zhao J Morris DL 《Surgical laparoscopy, endoscopy & percutaneous techniques》2003,13(6):366-371
Pad burns during or after radiofrequency ablation (RFA) are a skin complication probably underreported in the literature. We report on 4 severe pad burns, deep second and third degree, in 3 patients undergoing radiofrequency ablation of liver malignancies, 1 percutaneously and the other 2 after laparotomy. All burns occurred at the leading edge or at the corner of the pads attached to the patients' thighs. Potential causes leading to the burns are discussed. Current dispersive pad designs do not prevent the leading edge phenomenon and subsequent burns. Further developmental work in the pad design with the possibility of skin temperature monitoring via temperature sensors under the leading pad edge is needed. 相似文献
103.
104.
Lino Möhrmann Martina K. Zowada Hendrik Strakerjahn Christine Siegl Annette Kopp-Schneider Damir Krunic Dirk Strunk Martin Schneider Mark Kriegsmann Katharina Kriegsmann Friederike Herbst Claudia R. Ball Hanno Glimm Sebastian M. Dieter 《International journal of cancer. Journal international du cancer》2020,147(2):519-531
Disseminated tumor cells (dTCs) can frequently be detected in the bone marrow (BM) of colorectal cancer (CRC) patients, raising the possibility that the BM serves as a reservoir for metastatic tumor cells. Identification of dTCs in BM aspirates harbors the potential of assessing therapeutic outcome and directing therapy intensity with limited risk and effort. Still, the functional and prognostic relevance of dTCs is not fully established. We have previously shown that CRC cell clones can be traced to the BM of mice carrying patient-derived xenografts. However, cellular interactions, proliferative state and tumorigenicity of dTCs remain largely unknown. Here, we applied a coculture system modeling the microvascular niche and used immunofluorescence imaging of the murine BM to show that primary CRC cells migrate toward endothelial tubes. dTCs in the BM were rare, but detectable in mice with xenografts from most patient samples (8/10) predominantly at perivascular sites. Comparable to primary tumors, a substantial fraction of proliferating dTCs was detected in the BM. However, most dTCs were found as isolated cells, indicating that dividing dTCs rather separate than aggregate to metastatic clones—a phenomenon frequently observed in the microvascular niche model. Clonal tracking identified subsets of self-renewing tumor-initiating cells in the BM that formed tumors out of BM transplants, including one subset that did not drive primary tumor growth. Our results indicate an important role of the perivascular BM niche for CRC cell dissemination and show that dTCs can be a potential source for tumor relapse and tumor heterogeneity. 相似文献
105.
Roghieh Djafarzadeh PhD Claudius Conrad MD PhD Susan Notohamiprodjo MD Stephanie Hipp Hanno Niess MD Christiane J. Bruns MD PhD Peter J. Nelson PhD 《Wound repair and regeneration》2014,22(1):70-76
The balance between matrix metalloproteinases and their endogenous tissue inhibitors (TIMPs) is an important component in effective wound healing. The biologic action of these proteins is linked in part to the stoichiometry of TIMP/matrix metalloproteinases/surface protein interactions. We recently described the effect of a glycosylphosphatidylinositol (GPI) anchored version of TIMP‐1 on dermal fibroblast biology. Here, cell proliferation assays, in vitro wound healing, electrical wound, and impedance measurements were used to characterize effects of TIMP‐1‐GPI treatment on primary human epidermal keratinocytes. TIMP‐1‐GPI stimulated keratinocyte proliferation, as well as mobilization and migration. In parallel, it suppressed the migration and matrix secretion of dermal myofibroblasts, and reduced their secretion of active TGF‐β1. Topical application of TIMP‐1‐GPI in an in vivo excisional wound model increased the rate of wound healing. The agent positively influenced different aspects of wound healing depending on the cell type studied. TIMP‐1‐GPI counters potential negative effects of overactive myofibroblasts and enhances the mobilization and proliferation of keratinocytes essential for effective wound healing. The application of TIMP‐1‐GPI represents a novel and practical clinical solution for facilitating healing of difficult wounds. 相似文献
106.
van den Hoek AM Heijboer AC Corssmit EP Voshol PJ Romijn JA Havekes LM Pijl H 《Diabetes》2004,53(8):1949-1952
Peptide YY(3-36) (PYY(3-36)) is released by the gut in response to nutrient ingestion. It modulates the activities of orexigenic neuropeptide Y (NPY) neurons and anorexigenic proopiomelanocortin (POMC) neurons in the hypothalamus to inhibit food intake. Because both NPY and POMC have also been shown to impact insulin action, we wondered whether PYY(3-36) could improve insulin sensitivity. To address this question, we examined the acute effect of intravenous PYY(3-36) on glucose and free fatty acid (FFA) flux during a hyperinsulinemic-euglycemic clamp in mice maintained on a high-fat diet for 2 weeks before the experiment. We also evaluated the effects of PYY(3-36) infusion on glucose uptake in muscle and adipose tissue in this experimental context. Under basal conditions, none of the metabolic parameters were affected by PYY(3-36). Under hyperinsulinemic conditions, glucose disposal was significantly increased in PYY(3-36)-infused compared with vehicle-infused mice (103.8 +/- 10.9 vs. 76.1 +/- 11.4 micromol.min(-1).kg(-1), respectively; P = 0.001). Accordingly, glucose uptake in muscle and adipose tissue was greater in PYY(3-36)-treated animals, although the difference with controls did not reach statistical significance in adipose tissue (muscle: 2.1 +/- 0.5 vs. 1.5 +/- 0.5 micromol/g tissue, P = 0.049; adipose tissue: 0.8 +/- 0.4 vs. 0.4 +/- 0.3 micromol/g tissue, P = 0.08). In contrast, PYY(3-36) did not impact insulin action on endogenous glucose production or FFA metabolism. These data indicate that PYY(3-36) reinforces insulin action on glucose disposal in mice fed a high-fat diet, through a mechanism that is independent of food intake and body weight. In contrast, it leaves glucose production and lipid flux largely unaffected in this experimental context. 相似文献
107.
108.
109.
110.