全文获取类型
收费全文 | 1470篇 |
免费 | 70篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 29篇 |
妇产科学 | 16篇 |
基础医学 | 213篇 |
口腔科学 | 28篇 |
临床医学 | 138篇 |
内科学 | 298篇 |
皮肤病学 | 21篇 |
神经病学 | 160篇 |
特种医学 | 105篇 |
外科学 | 268篇 |
综合类 | 12篇 |
预防医学 | 62篇 |
眼科学 | 16篇 |
药学 | 77篇 |
中国医学 | 2篇 |
肿瘤学 | 72篇 |
出版年
2023年 | 19篇 |
2022年 | 33篇 |
2021年 | 40篇 |
2020年 | 25篇 |
2019年 | 26篇 |
2018年 | 48篇 |
2017年 | 29篇 |
2016年 | 43篇 |
2015年 | 37篇 |
2014年 | 56篇 |
2013年 | 84篇 |
2012年 | 98篇 |
2011年 | 103篇 |
2010年 | 58篇 |
2009年 | 48篇 |
2008年 | 100篇 |
2007年 | 104篇 |
2006年 | 80篇 |
2005年 | 95篇 |
2004年 | 80篇 |
2003年 | 84篇 |
2002年 | 77篇 |
2001年 | 11篇 |
2000年 | 11篇 |
1999年 | 8篇 |
1998年 | 13篇 |
1997年 | 11篇 |
1996年 | 8篇 |
1995年 | 6篇 |
1994年 | 4篇 |
1993年 | 6篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 3篇 |
1978年 | 2篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1937年 | 2篇 |
1933年 | 14篇 |
1932年 | 2篇 |
1931年 | 4篇 |
1930年 | 5篇 |
1922年 | 3篇 |
1915年 | 3篇 |
1914年 | 2篇 |
1913年 | 4篇 |
1912年 | 5篇 |
排序方式: 共有1544条查询结果,搜索用时 31 毫秒
61.
Prostate cancer detection on transrectal ultrasonography‐guided random biopsy despite negative real‐time magnetic resonance imaging/ultrasonography fusion‐guided targeted biopsy: reasons for targeted biopsy failure
下载免费PDF全文
![点击此处可从《BJU international》网站下载免费的PDF全文](/ch/ext_images/free.gif)
62.
Zola H Swart B Banham A Barry S Beare A Bensussan A Boumsell L D Buckley C Bühring HJ Clark G Engel P Fox D Jin BQ Macardle PJ Malavasi F Mason D Stockinger H Yang X 《Journal of immunological methods》2007,319(1-2):1-5
The Human Leucocyte Differentiation Antigens Workshops (HLDA) have since 1984 provided a forum for the characterization and study of leucocyte surface molecules and antibodies against them. HLDA devised the CD nomenclature, which is sanctioned by IUIS. The HLDA Council reviewed and modified the objectives of HLDA in 2004, and changed the name of the organization to Human Cell Differentiation Molecules (HCDM) to reflect the broader objectives. Workshop studies under the HCDM banner proceeded during 2005 and early 2006, culminating in a meeting in May 2006. At that meeting the Council, acting as Nomenclature Committee, approved a number of new CD designations and changes to some pre-existing CD designations, which are summarized in this report. 相似文献
63.
Jennifer Klump Ulrike Phillipp Marie Follo Anna Eremin Hannes Lehmann Sigrun Nestel Nikolas von Bubnoff Irina Nazarenko 《Nanomedicine : nanotechnology, biology, and medicine》2018,14(3):875-882
Clinical evidence in oncology argues for the advantages of performing molecular analysis of blood biomarkers to provide information about systemic changes and tumor heterogeneity.Whereas the diagnostic value of cell-free circulating DNA (fcDNA) has successfully been demonstrated in several studies, DNA enclosed in extracellular vesicles (EV) has only recently been described, and its potential diagnostic value is unclear. We established a protocol for separation of EV and fc fractions and tested for presence of mutant BRAFV600E mediating resistance to Vemurafenib and cKITD816V mediating resistance to Imatinib in blood of patients with melanoma and mastocytosis. Our results show that EV contain significantly higher amounts of total DNA as compared to the fc fraction. However, about ten-fold higher copy numbers of the wild type and mutant BRAF and cKIT were detected in the fcDNA fraction supporting its diagnostic value and pointing to differences in fc and EV DNA content. 相似文献
64.
BACKGROUND: Copayments are common measures intended to control drug expenditures and promote rational prescribing. In Finland, new antiglaucoma drugs start with a high copayment, but once sufficient clinical experience is available, they are reevaluated and can receive a lower copayment status. OBJECTIVE: This study assessed the effect of changes in copayment level on the adoption of 2 antiglaucoma drugs. METHODS: A retrospective analysis was performed from 1997 to 2001 using the Finnish national register of reimbursed drug purchases, which covers approximately 98% of all antiglaucoma drug purchases in the country. There were 172,293 purchases of dorzolamide (plain or combined with timolol) and 281,377 purchases of latanoprost. An interrupted time-series design from approximately 30 months before and 20 months after the change in copayment was used in the analysis. The main outcome measures were the numbers of defined daily doses (DDDs) purchased and the monthly numbers of patients who purchased the study drugs for the first time before and after the change in copayment. RESULTS: A substantial increase in consumption of both dorzolamide and latanoprost was seen immediately after the introduction of the lower copayment. The monthly consumption of dorzolamide was 60,713 DDDs higher and the monthly consumption of latanoprost was 49,330 DDDs higher than expected according to the utilization trend during the higher copayment period. Twelve months later, the observed consumption of dorzolamide was 109% higher and that of latanoprost was 21% higher than if the copayment had remained the same. The number of new patients using the study drugs peaked within 2 months of the lower copayment, but the amount consumed per patient per day remained quite stable. CONCLUSIONS: Decreasing the copayment of a new antiglaucoma drug to the same level as the copayments of alternative drugs accelerated the adoption of these new products in Finland. 相似文献
65.
Georg R. Linke Tobias Gehrig Lena V. Hogg Anna Göhl Hannes Kenngott Fritz Schäfer Lars Fischer Carsten N. Gutt Beat P. Müller-Stich 《Surgery today》2014,44(5):820-826
Purpose
Laparoscopic hiatal hernia repair with additional fundoplication is a commonly recommended standard surgical treatment for symptomatic large hiatal hernias with paraesophageal involvement (PEH). However, due to the risk of persistent side effects, this method remains controversial. Laparoscopic mesh-augmented hiatoplasty without fundoplication (LMAH), which combines hiatal repair and mesh reinforcement, might therefore be an alternative.Methods
In this retrospective study of 55 (25 male, 30 female) consecutive PEH patients, the perioperative course and symptomatic outcomes were analyzed after a mean follow-up of 72 months.Results
The mean DeMeester symptom score decreased from 5.1 to 1.8 (P < 0.001) and the gas bloating value decreased from 1.2 to 0.5 (P = 0.001). The dysphagia value was 0.7 before surgery and 0.6 (P = 0.379) after surgery. The majority of the patients were able to belch and vomit (96 and 92 %, respectively). Acid-suppressive therapy on a regular basis was discontinued in 68 % of patients. In 4 % of patients, reoperation was necessary due to recurrent or persistent reflux. A mesh-related stenosis that required endoscopic dilatation occurred in 2 % of patients.Conclusions
LMAH is feasible, safe and provides an anti-reflux effect, even without fundoplication. As operation-related side effects seem to be rare, LMAH is a potential treatment option for large hiatal hernias with paraesophageal involvement. 相似文献66.
Netzer Nikolaus C. Rausch Linda K. Gatterer Hannes Burtscher Martin Eliasson Arn H. Pramsohler Stephan 《Sleep & breathing》2021,25(2):951-955
Sleep and Breathing - Severely fractured sleep is mostly portrayed negatively, but investigations in extreme sports show that humans can maintain performance with a minimum of sleep. With two cases... 相似文献
67.
Herwig R Glodny B Kühle C Schlüter B Brinkmann OA Strasser H Senninger N Winde G 《Diseases of the colon and rectum》2002,45(4):514-521
PURPOSE: The assessment of plasma cytokine levels adds a useful tool to the diagnostic measures in severe inflammatory diseases. Proinflammatory cytokine levels in abdominal fluid after abdominal surgery have been shown to far exceed plasma cytokine levels. Thus, we investigated the local release of interleukin 1, interleukin 6, and tumor necrosis factor- in patients after colorectal surgery during the early postoperative period to evaluate whether it may serve as an indicator of evolving peritonitis.
METHOD: In a prospective, observational pilot study, the first 12 consecutive patients who did not develop any postoperative complications (Group I), and the first 12 patients with secondary peritonitis caused by an anastomotic leakage (Group II), were included in the study. Interleukin 6, interleukin 1, and tumor necrosis factor- levels were determined in the abdominal exudate and compared between the groups within the first four days after colorectal surgery.
RESULTS: Abdominal fluid interleukin 6 levels in Group II patients were higher (162,500 ± 105,800 pg/ml) as early as the first postoperative day compared with Group I (27,940 ± 13,860 pg/ml; P < 0.0001); this lasted for the whole observation period. The same applies to tumor necrosis factor- levels (461.4 ± 167.8 pg/ml vs. 175.8 ± 178.6 pg/ml on day 1; P = 0.0007). The difference in interleukin 1 cytokine levels became statistically significant on the third postoperative day. Moreover, abdominal fluid cytokine levels rose in Group II, whereas they remained virtually unchanged or even tended to decrease over time in Group I.
CONCLUSION: We suggest that the estimation of the peritoneal cytokine levels might be an additional diagnostic tool that can support the early recognition of peritonitic complications in colorectal surgery. 相似文献
68.
Michels R Hoffmann H Windeler J Barth H Hopkins G 《Journal of thrombosis and thrombolysis》1995,2(2):117-124
Background: Urokinase or two-chain urokinasetype plasminogen activator has been shown to be effective in the treatment of acute myocardial infarction. Its parent molecule, single-chain urokinase-type plasminogen activator (scu-PA), unlike urokinase, can selectively activate fibrinbound plasminogen. The induced clot lysis is amplified by plasmin-triggered conversion of scu-PA to urokinase and by further plasmin generation. The aim of our study was to compare the efficacy and safety of recombinant unglycosylated scu-PA, or saruplase, and urokinase at doses considered optimal in patients with acute myocardial infarction within 6 hours of onset of pain. Methods and results: In a double-blind trial 543 patients were randomized to saruplase (20 mg bolus + 60 mg/hr) or urokinase (1.5 million unit bolus + 1.5 million units/hr). Primary endpoint: The patency rates at 24–72 hours were 75.4% (95% CI 70.3–80.5%) for saruplase and 74.2% (95% CI 69.0–79.4%;P=0.77) for urokinase. Secondary endpoint: The incidence of bleeding events in both groups was 10.7%. There were three hemorrhagic strokes in the saruplase group (ns). Other efficacy and safety evaluations: Apart from the generation of more fibrinogen degradation products under saruplase, the changes in hemostatic parameters did not differ. Hospital mortality was 4.4% for saruplase and 8.1% for urokinase. This nonsignificant difference was maintained for 1 year. Conclusion: The efficacy and safety of saruplase and urokinase in the regimens used are very similar. 相似文献
69.
Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma 总被引:16,自引:1,他引:16
Kaufmann H Raderer M Wöhrer S Püspök A Bankier A Zielinski C Chott A Drach J 《Blood》2004,104(8):2269-2271
We evaluated a treatment strategy targeting both lymphoma cells (by rituximab) and the microenvironment (by thalidomide) in 16 patients with relapsed/refractory mantle cell lymphoma (MCL). Rituximab was administered at 375 mg/m(2) for 4 weekly doses concomitantly with thalidomide (200 mg daily, with a dose increment to 400 mg on day 15), which was continued as maintenance therapy until progression/relapse. Thirteen patients (81%) experienced an objective response, with 5 complete responders (31%). Median progression-free survival (PFS) was 20.4 months (95% confidence interval [CI], 17.3-23.6 months), and estimated 3-year survival was 75%. In patients achieving a complete response, PFS after rituximab plus thalidomide was longer than PFS after the preceding chemotherapy. Severe adverse events included 2 thromboembolic events and 1 grade IV neutropenia associated with thalidomide. Our results suggest that rituximab plus thalidomide has marked antitumor activity in relapsed/refractory MCL and a low toxicity profile, which warrants further evaluation in MCL. 相似文献
70.
Michael Huntgeburth Christoph Adler Stephan Rosenkranz Carsten Zobel Walter F. Haupt Christian Dohmen Hannes Reuter 《Neurocritical care》2014,20(3):358-366