Morbidity and Mortality in the Thirty-Day Period Following Total Hip Arthroplasty: Risk Factors and Incidence

The study sought to ascertain the incidence rates and risk factors for 30-day post-operative complications after primary total hip arthroplasty (THA). Complications were categorized as systemic or local and subcategorized as major or minor. There were 17,640 individuals who received primary THA identified from the 2006-2011 ACS NSQIP. The mortality rate was 0.35% and complications occurred in 4.9%. Age groups ≥ 80 years (P <0.001) and 70-79 years old (P = 0.003), and renal insufficiency (P = 0.02) best predicted mortality. Age ≥80 years (P <0.001) and cardiac disease (P = 0.01) were the strongest predictors of developing any postoperative complication. Morbid obesity (P <0.001) and operative time > 141 minutes (P <0.001) were strongly associated with the development of major local complications.     

Mid-Term Survivorship of Minimally Invasive Unicompartmental Arthroplasty With a Fixed-Bearing Implant: Revision Rate and Mechanisms of Failure

Minimally invasive unicondylar arthroplasty (UKA) continues to gain popularity for the management of patients with degenerative arthritis limited to one compartment of the knee. In this study, we examine a series of 517 fixed-bearing, cemented unicompartmental knee components implanted in patients to manage degenerative arthritis in the medial compartment of their knee. All UKAs were performed at a single institution using the same fixed-bearing design. In this study we sought to examine the survivorship of the UKA components and the mechanisms of failure for the knees that were revised. The survivorship and revision rate with this implant were similar to those found in other published reports of fixed-bearing unicompartmental arthroplasties performed through minimally invasive surgical techniques.     

Alpha-adrenoceptor changes after oestrogen treatment in platelets and other tissues in female rabbits

alpha 2-Adrenoceptors on blood platelets have been widely used as a model for alpha-adrenoceptors in less accessible tissues. The effect of oestrogen (200 micrograms/day intramuscularly) on alpha 2-adrenoceptor number and function was studied in immature female rabbits. alpha 2-adrenoceptor number was measured in whole platelets, and membrane preparations of forebrain, hindbrain, spleen and kidney by radioligand binding. alpha 2-Adrenoceptor function was examined by measuring platelet aggregation in vitro and circulatory responses to selective alpha 2-adrenoceptor agonists in vivo. Oestrogen treatment resulted in a significant decrease in platelet alpha 2-adrenoceptor number and function. However, no changes were observed either in receptor number in other tissues or in responses to alpha 2-agonists in vivo. The results suggest that oestrogen modulation of rabbit platelet alpha 2-adrenoreceptor number and function may be different from that of brain, kidney and spleen. Caution should be exercised in extrapolating results from platelets to alpha-adrenoceptors at other sites.     

The impact of racial/ethnic disparities on survival for children and adolescents with extremity sarcomas: A population-based study

Purpose

The purpose of this study was to determine whether racial/ethnic disparities exist in disease presentation, treatment, and survival among children and adolescents with extremity sarcoma.

Lymphadenectomy in Gleason 7 prostate cancer: Adherence to guidelines and effect on clinical outcomes

Background

To examine usage trends, guideline adherence, and survival data for patients undergoing lymphadenectomy (LND) at the time of radical prostatectomy (RP) for Gleason 7 prostate cancer (PCa).

An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning

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Single-item satisfaction scores mask large variations in pain,function and joint awareness in patients following total joint arthroplasty

European Journal of Orthopaedic Surgery & Traumatology - Single-item questions assessing patient satisfaction following total hip or knee arthroplasty (THA/TKA) provide immediate and...