全文获取类型
收费全文 | 4932篇 |
免费 | 355篇 |
国内免费 | 156篇 |
专业分类
耳鼻咽喉 | 122篇 |
儿科学 | 125篇 |
妇产科学 | 117篇 |
基础医学 | 728篇 |
口腔科学 | 159篇 |
临床医学 | 522篇 |
内科学 | 947篇 |
皮肤病学 | 59篇 |
神经病学 | 267篇 |
特种医学 | 163篇 |
外国民族医学 | 3篇 |
外科学 | 800篇 |
综合类 | 118篇 |
一般理论 | 4篇 |
预防医学 | 295篇 |
眼科学 | 122篇 |
药学 | 511篇 |
中国医学 | 52篇 |
肿瘤学 | 329篇 |
出版年
2024年 | 4篇 |
2023年 | 44篇 |
2022年 | 109篇 |
2021年 | 219篇 |
2020年 | 134篇 |
2019年 | 176篇 |
2018年 | 233篇 |
2017年 | 141篇 |
2016年 | 160篇 |
2015年 | 182篇 |
2014年 | 240篇 |
2013年 | 290篇 |
2012年 | 495篇 |
2011年 | 439篇 |
2010年 | 226篇 |
2009年 | 179篇 |
2008年 | 253篇 |
2007年 | 356篇 |
2006年 | 241篇 |
2005年 | 210篇 |
2004年 | 163篇 |
2003年 | 161篇 |
2002年 | 139篇 |
2001年 | 61篇 |
2000年 | 54篇 |
1999年 | 43篇 |
1998年 | 48篇 |
1997年 | 45篇 |
1996年 | 39篇 |
1995年 | 14篇 |
1994年 | 32篇 |
1993年 | 31篇 |
1992年 | 30篇 |
1991年 | 39篇 |
1990年 | 21篇 |
1989年 | 27篇 |
1988年 | 22篇 |
1987年 | 21篇 |
1986年 | 9篇 |
1985年 | 15篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1981年 | 5篇 |
1980年 | 8篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 7篇 |
1974年 | 8篇 |
1973年 | 10篇 |
1971年 | 4篇 |
排序方式: 共有5443条查询结果,搜索用时 31 毫秒
101.
Liver transplantation as a definitive treatment for familial hypercholesterolemia: A series of 36 cases
下载免费PDF全文
![点击此处可从《Pediatric transplantation》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mohsenreza Mansoorian Kourosh Kazemi Saman Nikeghbalian Alireza Shamsaeefar Maral Mokhtari Seyed Mohsen Dehghani Ali Bahador Heshmatollah Salahi Hamid Amoozgar Seyed Ali Malek Hosseini 《Pediatric transplantation》2015,19(6):605-611
FH is a genetic disorder characterized by an increase in serum LDL and total cholesterol values. The afflicted patients are at increased risk of premature atherosclerosis and myocardial infarction. Different treatment modalities are present, including pharmacological agents and surgical procedures. The most effective method of therapy in refractive cases is liver transplantation. Herein, we report our experience on 36 cases of patients with FH undergoing liver transplantation in our center, the main referral center of liver transplantation in Iran. The clinical findings, hospital courses, post‐operative complications, and patient follow‐up are also described. 相似文献
102.
The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Sachiko Miyake Mark L. Lupher Jr. Brian Druker Hamid Band 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(14):7927-7932
The Cbl protooncogene product has emerged as a negative regulator of receptor and nonreceptor tyrosine kinases. We recently demonstrated that oncogenic Cbl mutants upregulate the endogenous tyrosine kinase signaling machinery when expressed in the NIH 3T3 cells, and identified the platelet-derived growth factor receptor-α (PDGFRα) as one of the tyrosine kinases targeted by these oncogenes. These findings suggested a role for the normal Cbl protein in negative regulation of the PDGFRα. However, the mechanism of such negative regulation remained to be determined. Here we show that overexpression of the wild-type Cbl enhances the ligand-induced ubiquitination of the PDGFRα. Concomitantly, the PDGFRα in Cbl-overexpressing cells undergoes a faster ligand-induced degradation compared with that in the control cells. These results identify a role for Cbl in the regulation of ligand-induced ubiquitination and degradation of receptor tyrosine kinases and suggest one potential mechanism for evolutionarily conserved negative regulatory influence of Cbl on tyrosine kinases. 相似文献
103.
Gholamhossein Ajami Ahmad Ali Amirghofran Hamid Amoozgar Mohammad Borzouee 《Iranian journal of pediatrics.》2015,25(5)
Introduction:
Truncus arteriosus with intact ventricular septum is a rare and unique variant of persistent truncus arteriosus (PTA) which usually presents with central cyanosis and congestive heart failure in neonate and early infancy. Associated cardiac and non-cardiac anomalies may affect morbidity and mortality of these patients.Case Presentation:
We describe clinical presentation, echocardiography and angiographic features of a 7-month old boy with PTA and intact ventricular septum who underwent surgical repair of the anomaly at our institution. Operative findings, surgical procedure and short-term outcome are reported.Conclusions:
While our patient had systemic pulmonary arterial pressure at the time of complete surgical repair, it was improved after surgery. 相似文献104.
M el-Touny L Osman T Abd-el Hamid M S Sabbour 《The Journal of tropical medicine and hygiene》1989,92(1):6-9
In view of high mortality, variable clinical presentation, and late results of bacterial culture, early diagnosis of SBP and treatment are based on indirect parameters of infection. Forty-two patients with ascites and liver cirrhosis were studied. Ascitic fluid (AF) was examined for total protein content, pH, lactate dehydrogenase, amylase, absolute polymorphonuclear cell count (PMN) and for presence of bacteria by examining a fresh smear of the deposit and culture of the fluid under aerobic and anaerobic conditions. AF/serum gradient of total proteins and LDH was calculated. One patient proved to have a malignant ascites and was excluded. The remaining 41 patients fell into two groups: Group I PMN less than 250 cell mm-3, culture negative, sterile ascites, 36 patients. Group II PMN greater than 250 cell mm-3. (a) Culture positive neutrophilic ascites (SBP), three patients. (b) Culture negative neutrophilic ascites (CNNA), two patients. In both CNNA and SBP:AF/serum total LDH gradient greater than 0.75 In the sterile group: AF/serum total LDH gradient less than 0.58 There was no correlation between presence of infection and ascitic fluid pH, protein content and AF/serum total protein gradient. Therefore AF PMN greater than 250 mm and AF/serum total LDH gradient greater than 0.6 should be considered reliable, indirect parameters of infection, and CNNA a variant of SBP with a small bacterial inoculum size. 相似文献
105.
Giulio Innamorati Hamid M. Sadeghi Nathaniel T. Tran Mariel Birnbaumer 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(5):2222-2226
Receptor recycling plays a critical role in the regulation of cellular responsiveness to environmental stimuli. Agonist-promoted phosphorylation of G protein-coupled receptors has been related to their desensitization, internalization, and sequestration. Dephosphorylation of internalized G protein-coupled receptors by cytoplasmic phosphatases has been shown to be pH-dependent, and it has been postulated to be necessary for receptors to recycle to the cell surface. The internalized V2 vasopressin receptor (V2R) expressed in HEK 293 cells is an exception to this hypothesis because it does not recycle to the plasma membrane for hours after removal of the ligand. Because this receptor is phosphorylated only by G protein-coupled receptor kinases (GRKs), the relationship between recycling and GRK-mediated phosphorylation was examined. A nonphosphorylated V2R, truncated upstream of the GRK phosphorylation sites, rapidly returned to the cell surface after removal of vasopressin. Less-drastic truncations of V2R revealed the presence of multiple phosphorylation sites and suggested a key role for a serine cluster present at the C terminus. Replacement of any one of Ser-362, Ser-363, or Ser-364 with Ala allowed quantitative recycling of full-length V2R without affecting the extent of internalization. Examination of the stability of phosphate groups incorporated into the recycling S363A mutant V2Rs revealed that the recycling receptor was dephosphorylated after hormone withdrawal, whereas the wild-type V2R was not, providing molecular evidence for the hypothesis that GRK sites must be dephosphorylated prior to receptor recycling. These experiments uncovered a role for GRK phosphorylation in intracellular sorting and revealed a GRK-dependent anchoring domain that blocks V2R recycling. 相似文献
106.
Yuanyuan Feng Hannah McGowan Azin Semsar Hamid R. Zahiri Ivan M. George Timothy Turner Adrian Park Andrea Kleinsmith Helena M. Mentis 《International journal of computer assisted radiology and surgery》2018,13(9):1463-1472
Purpose
To assess a virtual pointer in supporting surgical trainees’ development of professional vision in laparoscopic surgery.Methods
We developed a virtual pointing and telestration system utilizing the Microsoft Kinect movement sensor as an overlay for any imagine system. Training with the application was compared to a standard condition, i.e., verbal instruction with un-mediated gestures, in a laparoscopic training environment. Seven trainees performed four simulated laparoscopic tasks guided by an experienced surgeon as the trainer. Trainee performance was subjectively assessed by the trainee and trainer, and objectively measured by number of errors, time to task completion, and economy of movement.Results
No significant differences in errors and time to task completion were obtained between virtual pointer and standard conditions. Economy of movement in the non-dominant hand was significantly improved when using virtual pointer (\(p = 0.012\)). The trainers perceived a significant improvement in trainee performance in virtual pointer condition (\(p < 0.001\)), while the trainees perceived no difference. The trainers’ perception of economy of movement was similar between the two conditions in the initial three runs and became significantly improved in virtual pointer condition in the fourth run (\(p = 0.017\)).Conclusions
Results show that the virtual pointer system improves the trainer’s perception of trainee’s performance and this is reflected in the objective performance measures in the third and fourth training runs. The benefit of a virtual pointing and telestration system may be perceived by the trainers early on in training, but this is not evident in objective trainee performance until further mastery has been attained. In addition, the performance improvement of economy of motion specifically shows that the virtual pointer improves the adoption of professional vision— improved ability to see and use laparoscopic video results in more direct instrument movement.107.
Objective
The most prominent problem resulting from decreased body function in older adults is declining quality of life. Walking and talking among older adults in peer group may become a nursing therapy to improve their quality of life. The objective of this study was to identify the impact of walking and talking intervention of quality of life among community dwelling older adults in Depok, Indonesia.Method
This study applied quasi-experimental design with 43 and 40 older adults in the intervention and control group, respectively. The participants were selected using multistage random sampling method.Results
Based on t test, the average quality of life score of older adults improved more significantly in the intervention group than that in the control group, with p value of 0.003, its mean p value < α, respectively. An ANCOVA analysis was used to detect confounding factors. The result showed that all characteristics have a p value of > 0.05, which means there were no confounding factors warranting further investigation.Conclusions
It was concluded that walking and talking therapy in peer group significantly increase the quality of life of older adults. 相似文献108.
109.
Objective
This study aimed to identify the association between stereotyping and professional intercollaborative practice.Method
This study used a cross-sectional analytical study involving physicians, nurses, pharmacists, and dietitians in a hospital in Jakarta, Indonesia, who were selected using the stratified random sampling method. Data was collected using the Student Stereotypes Rating Questionnaire (SSRQ) and the Assessment of Interprofessional Team Collaboration Scale (AITCS). The stereotyping level was analyzed based on a nine-point SSRQ, while interprofessional collaborative practice was scored based on partnership/shared decision-making, cooperation, and coordination.Results
Stereotyping was shown to significantly correlate with interprofessional collaborative practice as measured by the SSRQ and AITCS.Conclusions
Poor interprofessional collaborative practice in subscale partnership/decision-making was dominant. Also, low-rating stereotyping was shown to be dominant with poor interprofessional collaborative practice.Recommendation
The research recommends that health care providers improve partnership/ decision-making skills for better interprofessional collaboration. For further research, it's recommended to explore another barrier of interprofessional collaborative practice. 相似文献110.
Hamid Shokoohi MD MPH RDMS RDCS FACEP Zachary Kendrick MD Neal Sikka MD Keith S. Boniface MD RDMS RDCS 《Journal of clinical ultrasound : JCU》2018,46(4):296-298
A retained urethral foreign body is an uncommon presentation in the Emergency Department. The diagnosis and treatment of retained urethral foreign bodies are determined by their size, location, shape, and mobility and often require specialty consultation and operative intervention. In this case of a 74‐year‐old man with a self‐inserted, retained urethral foreign body, we present the utility of a bedside ultrasound to detect the depth, size, and distance from the meatus of the object to guide the approach to extraction of the object at the bedside in the Emergency Department. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 46 :296–298, 2018 相似文献