全文获取类型
收费全文 | 1688篇 |
免费 | 79篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 58篇 |
妇产科学 | 130篇 |
基础医学 | 133篇 |
口腔科学 | 98篇 |
临床医学 | 151篇 |
内科学 | 380篇 |
皮肤病学 | 57篇 |
神经病学 | 139篇 |
特种医学 | 63篇 |
外科学 | 226篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 53篇 |
眼科学 | 22篇 |
药学 | 87篇 |
中国医学 | 2篇 |
肿瘤学 | 123篇 |
出版年
2022年 | 12篇 |
2021年 | 36篇 |
2020年 | 10篇 |
2019年 | 31篇 |
2018年 | 24篇 |
2017年 | 22篇 |
2016年 | 39篇 |
2015年 | 40篇 |
2014年 | 36篇 |
2013年 | 76篇 |
2012年 | 101篇 |
2011年 | 107篇 |
2010年 | 59篇 |
2009年 | 55篇 |
2008年 | 104篇 |
2007年 | 125篇 |
2006年 | 130篇 |
2005年 | 110篇 |
2004年 | 98篇 |
2003年 | 108篇 |
2002年 | 83篇 |
2001年 | 12篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 9篇 |
1997年 | 16篇 |
1996年 | 16篇 |
1995年 | 15篇 |
1994年 | 13篇 |
1993年 | 12篇 |
1992年 | 18篇 |
1991年 | 11篇 |
1990年 | 12篇 |
1989年 | 17篇 |
1988年 | 10篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 14篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1978年 | 9篇 |
1977年 | 8篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1973年 | 6篇 |
1971年 | 6篇 |
1970年 | 6篇 |
1968年 | 6篇 |
排序方式: 共有1771条查询结果,搜索用时 15 毫秒
91.
Martha Dirnfeld Yael Gonen Arie Lissak Shlomit Goldman Mara Koifman Yoram Sorokin Haim Abramovici 《Journal of assisted reproduction and genetics》1991,8(6):339-343
Fifty four women with repeated unsuccessful in vitro fertilization (IVF) cycles due to inadequate ovarian response to stimulation with human menopausal gonadotropins (hMG) participated in this study. They were randomized to receive either gonadotropin releasing hormone agonist (GNRHa), Buserelin, prior to and during induction of ovulation by hMG (Group I—long protocol), or GnRHa starting on the first day of the cycle together with induction of ovulation by hMG (Group II—short protocol). Mean follicular phase serum luteinizing hormone (LH) and progesterone (P) levels were significantly lower in Group I than in Group II (P<0.01). Cancellation rate was significantly lower in Group I than in Group II (P<0.01). The long GNRHa protocol resulted in statistically significant lower cancellation rates, more oocytes per pickup (OPU), more embryos trans-ferred per patient, and a higher pregnancy rate. Significantly more hMG ampoules and more treatments days were required in the long GNRHa protocol. Our data demonstrate that the use of GNRHa prior to and during ovarian stimulation with hMG offers a very good alternative for patients with repetitive unsuccessful IVF cycles due to inadequate response. 相似文献
92.
Moshe E. Stein Keren Drumea Ofer Ben-Itshak Aharon Hoffman Abraham Eyal Boaz Moshkovitz Nissim Haim 《Pediatric blood & cancer》1995,25(2):126-129
Arterial tumor embolization is a rare but serious complication of neoplastic disease. The majority of these tumors are associated with primary or secondary lung malignancies, originating from pulmonary vein metastasis or from an atrial mass. Malignant germ cell tumors primarily disseminate to the retroperitoneal lymph nodes and lung, and to the brain and liver later in the course of the disease. A germ cell tumor metastasis embolizing to the iliac-femoral arterial system has not yet been reported. We report a metastatic embolism in a patient with disseminated embryonal cell carcinoma causing acute limb ischemia, managed by surgical embolectomy. The sudden development of limb ischemia in a patient with a germ cell tumor should alert the physician to the possibility of tumor embolism. © 1995 Wiley-Liss, Inc. 相似文献
93.
Nissim Haim Michelle Leviov Yehudith Ben-Arieh Ron Epelbaum Nahum Freidin Ron Reshefs Menachem Ben-Shahar 《Leukemia & lymphoma》1995,17(3):321-326
The role of surgery as initial treatment in gastric lymphoma remains controversial. We have prospectively evaluated a stomach conservation strategy in histologically aggressive gastric lymphoma, using primary adriamycin-containing chemotherapy, followed by involved-field radiotherapy in patients with limited disease. Twenty-six patients (median age 69 years) were entered in this study; 15 had stage I disease, 7 had stage II disease and 4 had stage IV disease. The chemotherapy combinations were CHOP (18 patients) and ProMACE/MOPP (8 patients). Radiotherapy was given to 11 patients. Of the 24 patients evaluated for response, 18 (75%) achieved endoscopically-confirmed complete response and 4 (17%) partial response. During follow-up (median 22 months), none of the complete responders developed recurrent lymphoma. Gastric resection was performed in 1/26 patients who did not respond to primary chemotherapy. There were no cases of perforation, but three patients (12%) developed acute gastro-intestinal bleeding a few days after the onset of chemotherapy, one of whom required a surgical devascularization procedure. There was no treatment-related mortality. These data further support the non-surgical approach in histologically aggressive gastric lymphoma, using primary chemotherapy with or without radiation therapy. 相似文献
94.
95.
96.
Ozer E Adelman C Freeman S Sohmer H 《Journal of basic and clinical physiology and pharmacology》2002,13(2):89-96
Bone conduction stimulation of the teeth of the lower jaw initiates auditory sensations. However the lower jaw is only loosely coupled to the skull by the temporo-mandibular joint. Therefore the 'classical' bone conduction pathway involving skull vibration transmission entirely along bone to the temporal-petrous bone requires further consideration. Bone conduction hearing thresholds to stimulation at the forehead and at the teeth of the upper and lower jaw were determined in human subjects. Thresholds on the teeth were better than those on the forehead and there was no difference between the thresholds measured following stimulation of the upper and lower teeth. Experiments in guinea-pigs provided evidence that vibration of the teeth leads to transmission of the audio-frequency vibrations by means of soft tissue, through skull foramina, into the skull cavity (brain and CSF) and from there by fluid channels directly into inner ear fluids, exciting the cochlea. 相似文献
97.
A series of "binary prodrugs" called carbaphens,(1) carbamylated derivatives on one or both of the aromatic rings of the muscarinic receptor antagonist aprophen [(N,N-diethylamino)ethyl 2,2-diphenylpropionate], were synthesized to develop binary prophylactic agents against organophosphorus intoxication. As a group, the carbaphens retained the muscarinic receptor antagonist properties of aprophen but also preferentially inhibited butyrylcholinesterase (BChE) in contrast to acetylcholinesterase (AChE). Therefore, a new series of compounds named pyridophens were designed and synthesized to achieve binary prodrugs to preferentially inhibit AChE over BChE, while still retaining the muscarinic receptor antagonism of aprophen. The pyridophens consist of the basic pyridostigmine skeleton combined with the 2,2-diphenylpropionate portion of aprophen by replacement of the diethylamino group. Three compounds, 9 (a tertiary pyridine), 10 (a quaternary pyridine), and 12 (a tertiary tetrahydropyridine), were found to be effective inhibitors of both BChE and AChE. However, 10, N-methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2'2'-diphenylpropionoxy-methyl)pyridinium iodide, inhibited AChE selectively over BChE, with a bimolecular rate constant similar to pyridostigmine. In contrast to their potent cholinesterase inhibitory activity, all of the pyridophen analogues were less potent antagonists of the muscarinic receptor than aprophen. 相似文献
98.
99.
Inositol, a precursor of the PIP cycle that was reported to have therapeutic effects in depressive patients and to be effective in two animal models of depression, was evaluated in the forced swim test using the genetic Flinders Sensitive Line (FSL) rats model of depression. Groups of rats were tested in a 2 x 2 design with Strain (FSL or Control) as one factor and Drug (Inositol or Placebo) as the second factor. Rats received chronic treatment (daily for 14 days) with inositol (1.2 g/kg) or placebo (1:2 glucose/mannitol solution). On day 14 rats were exposed to the forced swim test for 5 min and their behavior videotaped. Tapes were analyzed for three levels of activity: immobility, swimming, and vigorous struggle. Inositol countered the exaggerated immobility of FSL rats in the forced swim test, without affecting control animals. Data support our previous suggestion of inositol as a potential antidepressant. 相似文献
100.
Melatonin production in infants 总被引:5,自引:0,他引:5
This study investigated the relationships of the excretion of the melatonin metabolite, 6-sulfatoxymelatonin, to prenatal, natal, and postnatal variables and its possible relation to psychomotor development. nocturnal urinary excretion of 6-sulfatoxymelatonin was studied over a 13-hour period in 355 term infants at 8 weeks of age (n = 320) and 16 weeks of age (n = 96). data on a variety of perinatal factors including pregnancy course, delivery, early postnatal course, birth weight, medical problems, growth (length, weight, and head circumference), and psychomotor development were collected at 1, 3, 6, 9, 12, and 18 months. the relationship between nocturnal 6-sulfatoxymelatonin excretion at 8 and 16 weeks of age and these factors was investigated and analyzed. 6-sulfatoxymelatonin levels at 16 weeks of age were significantly lower in infants with abnormal vs normal development at 3 months of age (7.27 + 1.44 vs 7.97 + 1.06, p = 0.05) as well as at 6 months of age (7.15 + 1.29 vs 7.95 + 1.10, p = 0.04). no other significant relation was evident among growth, perinatal complications, medical problems, and 6-sulfatoxymelatonin excretion at 8 weeks of age and at 16 weeks of age. low melatonin excretion in the first weeks of life correlates with delayed psychomotor achievements at 3 and 6 months of age. this association suggests a causal or predictive link between melatonin and neurodevelopment in infants. 相似文献