全文获取类型
收费全文 | 1678篇 |
免费 | 81篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 58篇 |
妇产科学 | 130篇 |
基础医学 | 133篇 |
口腔科学 | 98篇 |
临床医学 | 150篇 |
内科学 | 376篇 |
皮肤病学 | 57篇 |
神经病学 | 137篇 |
特种医学 | 63篇 |
外科学 | 226篇 |
综合类 | 2篇 |
一般理论 | 1篇 |
预防医学 | 52篇 |
眼科学 | 22篇 |
药学 | 87篇 |
中国医学 | 2篇 |
肿瘤学 | 123篇 |
出版年
2021年 | 36篇 |
2020年 | 10篇 |
2019年 | 31篇 |
2018年 | 24篇 |
2017年 | 22篇 |
2016年 | 39篇 |
2015年 | 40篇 |
2014年 | 36篇 |
2013年 | 76篇 |
2012年 | 101篇 |
2011年 | 107篇 |
2010年 | 59篇 |
2009年 | 55篇 |
2008年 | 104篇 |
2007年 | 125篇 |
2006年 | 130篇 |
2005年 | 110篇 |
2004年 | 98篇 |
2003年 | 108篇 |
2002年 | 83篇 |
2001年 | 12篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 9篇 |
1997年 | 16篇 |
1996年 | 16篇 |
1995年 | 15篇 |
1994年 | 13篇 |
1993年 | 12篇 |
1992年 | 18篇 |
1991年 | 11篇 |
1990年 | 12篇 |
1989年 | 17篇 |
1988年 | 10篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 8篇 |
1984年 | 14篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1978年 | 9篇 |
1977年 | 8篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1973年 | 6篇 |
1971年 | 6篇 |
1970年 | 6篇 |
1968年 | 6篇 |
排序方式: 共有1763条查询结果,搜索用时 15 毫秒
21.
Schachter J Laish A Mekhmandarov S Feinmesser M Fenig E Tamir G Gutman H 《World journal of surgery》2000,24(4):491-495
Identification and histologic study of the sentinel node (SN) is an acceptable, yet not firmly established, guide for treating
intermediate-thickness melanoma. This study widens the range of applications of this technique. We included 97 patients with
intermediate-thickness melanoma lesions or lesions for which there is no standard treatment. Fifty-six underwent preoperative
lymphoscintigraphy, and all underwent intraoperative lymphatic mapping (IOLM) using blue dye, followed by frozen section study
and total node processing by serial sections. Elective lymph node dissection was performed in cases of metastasis to the sentinel
node or technical failures with high risk. Four categories were defined: (A) intermediate-thickness lesions (mean 2.27 mm)
(n= 45); (B) thin lesions (mean 1.14 mm) with risk factors of regional failure (n= 27); (C) lesion thickness close to but more than 4 mm (n= 10); and (D) lesions of undetermined thickness (n= 15). Median follow-up was 30 months (range 13–51 months). Intraoperative lymphatic mapping successfully identified the sentinel
node (SN) in 93% of basins explored. Metastases were detected in 11 SNs. There were three lymph basin recurrences in patients
with previously negative SNs, all salvaged by therapeutic lymph basin dissection and are NED (no evidence of disease). Two
SN+ patients had systemic recurrences; one died of his disease, and the other is alive with disease. One SN− patient died NED owing to other cause. This technique spared 83% of category A patients from lymph node dissection. It allowed
better staging and better decision making for treatment in categories B and D; and it prevented early regional recurrences
in category C patients. Intraoperative lymphatic mapping with SN guidance is a novel, low-morbidity approach applicable and
advantageous for a wide range and subgroups of melanoma patients. 相似文献
22.
Treatment variables in relation to oocyte maturation: Lessons from a clinical micromanipulation-assisted in vitro fertilization program 总被引:1,自引:0,他引:1
Ori M. Avrech Gil A. Goldman Onit Rufas Anat Stein Shoshana Amit Israel Yoles Haim Pinkas Benjamin Fisch 《Journal of assisted reproduction and genetics》1997,14(6):337-342
Objective: In an effort to understand the mechanism underlying the improved pregnancy rate observed in IVF cycles when gonadotropin-releasing
hormone analogues (GnRH-a) are applied, we investigated a possible relationship between treatment variables and oocyte-nuclear
maturity.
Design: Nuclear maturity was retrospectively assessed in cumulus-free, denuded oocytes, obtained from women undergoing micromanipulation-assisted
IVF treatment following controlled ovarian hyperstimulation with GnRH-a and menotropins.
Setting: The setting was the infertility and IVF unit of a tertiary academic medical center.
Participants: Two hundred twenty-one patients underwent 435 treatment cycles.
Main Outcome Measure: This was the proportion of germinal vesicle-intact immature (GVII) oocytes.
Results: One hundred fifty-four of the 3520 oocytes studied (4.4%) were in the GVII stage. These oocytes were found in 66 of the treatment
cycles (15.2%) and in 54 of the patients (24.4%). Cycles in which GVII oocytes were detected did not differ from those in
which all the aspirated oocytes were mature in the following respects: patient age, type and duration of infertility, controlled
ovarian hyperstimulation protocol and time of ovum pickup. However, the GVII group was characterized by a significantly higher
peak estradiol level, as well as a higher number of mature follicles visualized sonographically (diameter, >14 mm) and oocytes
retrieved.
Conclusions: Comparing the present findings with previously published data, it appears that the inclusion of GnRH-a in the stimulation
regimen is associated with a lower proportion of immature oocytes. A higher occurrence of oocyte-nuclear immaturity is apparently
associated with a significantly better ovarian response to stimulation. The high incidence of immature oocytes observed in
patients with normospermic partners and low fertilization rates in previous cycles may suggest that the fertilization failure
in some of these cases is due to oocyte, rather than sperm, dysfunction. 相似文献
23.
Ron Epelbaum Channa Shalitin Ruth Segal Clari Valansi Ida Arselan David Faraggi Michelle Leviov Menahem Ben-Shahar Nissim Haim 《Pathology oncology research : POR》1998,4(4):271-276
A novel serum 21 kDa haptoglobin-related protein (Hpr) was investigated in patients with malignant lymphoma, to evaluate its
correlation with clinical and histologic features at presentation and its possible role as a tumor marker for patient outcome.
One hundred fifty eight serum samples were taken from 88 patients with non-Hodgkin’s lymphoma (n=58) and Hodgkin’s disease
(n=30) at presentation and in the course of follow-up. Sera from 61 healthy volunteers served as normal controls. Serum Hpr
levels in the lymphoma patients (median 430xl03 u/ml, range 0-4000xl03) were significantly higher than in the control group (median 68xl03 u/ml, range 0-180xl03) (p=0.0001). Higher median Hpr values were detected in patients with advanced disease (p=0.013), “B” symptoms (p=0.029) and
in males (p=0.053). There was also a significant correlation between Hpr and erythrocyte sedimentation rate (p=0.028). Serial
determinations showed a significant decrease of the initial Hpr values obtained after treatment in 41 patients, 38 of whom
achieved complete remission. In the follow-up period additional Hpr measurements were taken from 17 patients. Three of them
eventually relapsed, and showed increased Hpr levels at the time of relapse. Hpr levels remained low in 11 of 14 patients
who maintained complete remission, and increased in three. In conclusion, serum Hpr is a new serum tumor marker of potential
use in the clinical setting of lymphoma.
This work is dedicated to the memory of Dr. Arie H. Bartal, a dedicated oncologist and friend. This work was supported by
Chemotech Thechnologies Ltd., by grant no. 3676 from the Chief Scientist’s Office of the Ministry of Health, Israel, and by
the Fund for Promotion of Research in the Technion. 相似文献
24.
25.
26.
27.
Karl M Potier M Schulman IH Rivera A Werner H Fornoni A Elliot SJ 《Endocrinology》2005,146(2):889-900
28.
Ike D. Tanabe M.D. Anthony DiTomaso M.D. Haim Pinkas M.D. Dobromir Pencev M.D. 《The American journal of gastroenterology》1995,90(3):504-505
We describe an unusual case of a 32-yr-old man who presented with massive GI hemorrhage as an initial manifestation of an ileal duplication cyst. The lesion was first revealed by visceral angiography during investigation of the bleeding source. At laparotomy, a large ileal duplication containing full-thickness gastric-type mucosa was identified. Ulceration of the ileal mucosa adjacent to the communicating orifice was found to be the source of bleeding. Duplications of the alimentary tract are rare congenital malformations. Patients usually present in infancy and childhood, although delayed complications can present in adulthood. This entity should be considered among other lesions that can cause massive GI hemorrhage not diagnosable by endoscopy. 相似文献
29.
30.
Epidemiological features of acute viral hepatitis among the Israeli Defence Forces, 1977-83 总被引:2,自引:0,他引:2
High morbidity rates of non-B hepatitis in the Israeli Defence Forces has stimulated efforts towards its prevention. This paper analyses morbidity over a period of 7 years since a programme of pre-exposure prophylaxis with human normal immunoglobulin began. Among 1480 cases studied, about 5% were of hepatitis B. In 360 patients further investigated 11% of illnesses were caused by hepatitis non-A non-B viruses; the remainder by hepatitis A virus. Females comprised about 15% of all three groups. Ethnic origin, social class and education were similar in all those with hepatitis A and non-A non-B hepatitis. This was not so for hepatitis B. None of those with hepatitis B gave a history of former blood transfusions or illicit use of drugs. The importance of risk groups and mode of transmission of the various hepatitis viruses is discussed. 相似文献