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31.
32.
Brian E. Dixon Jamie Pina Hadi Kharrazi Fardad Gharghabi Janise Richards 《Online Journal of Public Health Informatics》2015,7(2)
Objective: To categorize and describe the public health informatics (PHI) and
global health informatics (GHI) literature between 2012 and 2014.Methods: We conducted a semi-systematic review of articles published between
January 2012 and September 2014 where information and communications
technologies (ICT) was a primary subject of the study or a main component of the
study methodology. Additional inclusion and exclusion criteria were used to
filter PHI and GHI articles from the larger biomedical informatics domain.
Articles were identified using MEDLINE as well as personal bibliographies from
members of the American Medical Informatics Association PHI and GHI working
groups.Results: A total of 85 PHI articles and 282 GHI articles were identified. While
systems in PHI continue to support surveillance activities, we identified a
shift towards support for prevention, environmental health, and public health
care services. Furthermore, articles from the U.S. reveal a shift towards PHI
applications at state and local levels. GHI articles focused on telemedicine,
mHealth and eHealth applications. The development of adequate
infrastructure to support ICT remains a challenge, although we identified a
small but growing set of articles that measure the impact of ICT on clinical
outcomes.Discussion: There is evidence of growth with respect to both implementation of
information systems within the public health enterprise as well as a widening of
scope within each informatics discipline. Yet the articles also illuminate the
need for more primary research studies on what works and what does not as both
searches yielded small numbers of primary, empirical articles.Conclusion: While the body of knowledge around PHI and GHI continues to mature,
additional studies of higher quality are needed to generate the robust evidence
base needed to support continued investment in ICT by governmental health
agencies. 相似文献
33.
Eskandarifard Ebrahim Silva Rui Nobari Hadi Clemente Filipe Manuel Pérez-Gómez Jorge Figueiredo António José 《Sport Sciences for Health》2022,18(2):297-305
Sport Sciences for Health - The purposes of this study were to describe the fitness and hormonal levels according to playing time (PT) (i.e., PT during season less (PT1) or more (PT2) than 50% of... 相似文献
34.
A. Parsian R. D. Todd C. R. Cloninger P. L. Hoffman L. Ovchinnikova H. Ikeda B. Tabakoff 《Alcoholism, clinical and experimental research》1996,20(4):745-751
Adenylyl cyclase (AC) activity was measured in membrane preparations of platelets from control and alcoholic subjects. The sample consisted of 51 alcoholics who were categorized as type I or type II using the criteria of Gilligan et al. ( Genet. Epidemiol. 4:395–414, 1987) and 54 normal controls. Alcoholic males exhibited significantly lower values than controls in basal and fluoride-stimulated platelet AC activity. When male alcoholics were segregated into type I and type II categories, the platelet AC activity did not differ between subtypes, and both subtypes had AC activity that was below control values. Western blot analysis of the quantity of Gs α and Gi α proteins in a subset of male controls and alcoholic subjects demonstrated no significant relationship between quantity of G proteins and AC activity. The results confirm lower platelet AC activity in male alcoholics, compared with controls. Given the lack of quantitative relations between Gs α and Gi α proteins and AC activity, the results support the contention that individual differences in platelet AC activity in the alcoholic subjects may reflect quantitative or qualitative differences in the AC catalytic units. 相似文献
35.
NicholasA. Clanton Shayne D. Hastings Griffin B. Foultz Julie A. Contreras Samantha S. Yee Hadi D. Arman April L. Risinger Doug E. Frantz 《ACS medicinal chemistry letters》2020,11(12):2534
Natural products have served as inspirational scaffolds for the design and synthesis of novel antineoplastic agents. Here we present our preliminary efforts on the synthesis and biological evaluation of a new class of electrophilic steroids inspired by the naturally occurring taccalonolides. We demonstrate that these simplified analogs exhibit highly persistent antiproliferative properties similar to the taccalonolides and retain activity against resistant cancer cell lines that warrants further preclinical development. 相似文献
36.
Mohammad Afzalimoghaddam Maryam Feyiz Khademi Hadi Mirfazaelian Pooya Payandemehr Ehsan Karimialavijeh Alireza Jalali 《The Journal of emergency medicine》2021,60(1):1-7
BackgroundThe reduction of shoulder dislocation requires adequate procedural sedation and analgesia. The mixture of midazolam and fentanyl is reported in the literature, but long-acting benzodiazepines in conjunction with fentanyl are lacking.Study ObjectiveOur aim was to compar e IV diazepam with IV midazolam in moderate procedural sedation (based on the classification of the American Society of Anesthesiologists) for the reduction of shoulder dislocation.MethodsThis was a randomized controlled clinical trial conducted from April 2019 to December 2019 in the emergency department of a university-affiliated hospital in Tehran, Iran. Participants were adult patients (aged 18–65 years) with anterior shoulder dislocation. Group A (n = 42) received diazepam 0.1 mg/kg plus fentanyl 1 μg/kg IV and group B received midazolam 0.1 mg/kg plus fentanyl 1 μg g/kg IV. Main outcomes measured were onset of muscle relaxation, time taken to reduction, total procedure time, number of the reduction attempts, patient recovery time, the occurrence of the adverse effects, amount of the pain reported by the patients using visual analog scale, and patients and physicians overall satisfaction with the procedure using a Likert scale question.ResultsEighty-one patients were included. The mean ± standard deviation time of the onset of the muscle relaxation and time taken to reduction was shorter in the diazepam plus fentanyl group (p = 0.016 and p = 0.001, respectively). Adverse effects and pain relief were not statistically different between the two groups. Patient recovery time and total procedure time was shorter in the midazolam plus fentanyl group (p = 0.008 and p = 0.02, respectively). The overall satisfaction of patients and physicians was higher in the diazepam plus fentanyl group.ConclusionsAs compared with midazolam plus fentanyl, diazepam plus fentanyl was superior in terms of the onset of the muscle relaxation, patient and physician satisfaction, and time taken to reduction. 相似文献
37.
Mohammad Taherdangkoo Mohammad Hadi Bagheri Mehran Yazdi Katherine P. Andriole 《Journal of digital imaging》2013,26(6):1116-1123
Since segmentation of magnetic resonance images is one of the most important initial steps in brain magnetic resonance image processing, success in this part has a great influence on the quality of outcomes of subsequent steps. In the past few decades, numerous methods have been introduced for classification of such images, but typically they perform well only on a specific subset of images, do not generalize well to other image sets, and have poor computational performance. In this study, we provided a method for segmentation of magnetic resonance images of the brain that despite its simplicity has a high accuracy. We compare the performance of our proposed algorithm with similar evolutionary algorithms on a pixel-by-pixel basis. Our algorithm is tested across varying sets of magnetic resonance images and demonstrates high speed and accuracy. It should be noted that in initial steps, the algorithm is computationally intensive requiring a large number of calculations; however, in subsequent steps of the search process, the number is reduced with the segmentation focused only in the target area. 相似文献
38.
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40.
Mohamadnejad M Pourshams A Malekzadeh R Mohamadkhani A Rajabiani A Asgari AA Alimohamadi SM Razjooyan H Mamar-Abadi M 《World journal of gastroenterology : WJG》2003,9(10):2322-2324
AIM: The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors. METHODS: A total of 1,939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels. RESULTS: Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L, and for non-overweight men was 40 U/L. CONCLUSION: Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately. 相似文献