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21.
YOSHIO FURUKAWA M.D. Ph.D. TAKAHISA YAMADA M.D. Ph.D. TAKASHI MORITA M.D. Ph.D. YUSUKE IWASAKI M.D. MASATO KAWASAKI M.D. ATSUSHI KIKUCHI M.D. TAKASHI NAITO M.D. TADAO FUJIMOTO M.D. KENTARO OZU M.D. TAKUMI KONDO M.D. KAORUKO SENGOKU M.D. HIRONORI YAMAMOTO M.D. TOHRU MASUYAMA M.D. Ph.D. F.A.C.C. MASATAKE FUKUNAMI M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2013,24(6):632-639
22.
FUMIO YAMASHITA DAISAKU URABE HARUMICHI ITO SHIGENOBU KONDO YOSHIYUKI HANAWA 《Pediatrics international》1993,35(6):543-548
The experience gained during 7 years of cooperation between the Japan International Cooperation Agency (JICA) and the Islamabad Children's Hospital (JICA-ICH project, July 1986-June 1993) is described. Islamabad Children's Hospital achieved the goals of the project and became a centre for excellence in health care, education and research for children, fulfilling the objectives of the project. This achievement was evaluated as one of the most successful projects in medical cooperation ever performed by JICA by a third party evaluation team. The problems arising and the lessons experienced through the process are discussed. The importance of the role which should be undertaken by pediatricians in international cooperation with developing countries is emphasized. 相似文献
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YASUSHI TAKEDA HIROYOSHI SAWADA HIROFUMI SAWAI TOMOKO TOI-MATSUDA MASARO TASHIMA MINORU OKUMA SHIGEYA WATANABE SEIICHI OHMORI MASAO KONDO 《British journal of haematology》1995,90(1):207-209
Patients with idiopathic acquired sideroblastic anaemia (IASA) usually show macrocytic or normocytic anaemia and increased free erythrocyte protoporphyrin (FEP). The mean cell haemoglobin concentration is normal or slightly low. Here we report a pyridoxine-responsive IASA patient with microcytic and hypochromic anaemia and low FEL level; these features are usually seen in cases of hereditary sideroblastic anaemia. Microcytosis increased during therapy.
There may be a subgroup of IASA with microcytic and hypochromic anaemia, low normal FEP and some response to pyridoxine like hereditary sideroblastic anaemia. 相似文献
There may be a subgroup of IASA with microcytic and hypochromic anaemia, low normal FEP and some response to pyridoxine like hereditary sideroblastic anaemia. 相似文献
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SHIGEORI TAKENAKA HIROTAKA SATO YOSHIMITSU ITAKURA HIROKI KONDO MAKOTO TAKAGI 《Chemical biology & drug design》1996,48(4):397-400
A peptide–anthraquinone conjugate was designed and synthesized containing linked peptide chains composed of Asp-Pro-Ala-Ala-Leu-Lys-Arg-Ala-Arg-Asn-Thr-Glu-Ala-Ala-Arg-Arg-Ser-Arg-Ala-Arg-Lys-Leu-Gln-Arg-Met, representing the basic region of GCN4. The two peptides were joined with anthraquinone at its 1- and 8-positions in a two-fold symmetric fashion, mimicking dimeric DNA-binding proteins. Experimental data indicated both an interaction of the anthraquinone moiety with the DNA double strand and an increase in the α-helicity of the peptide moieties of the ligand when it binds to DNA. © Munksgaard 1996. 相似文献
26.
Experimental acute glomerulonephritis induced in the rabbit with a specific streptococcal antigen 总被引:1,自引:0,他引:1
N YOSHIZAWA S OSHIMA A TAKEUCHI S KONDO T ODA J SHIMIZU J NISHIYAMA A ISHIDA I NAKABAYASHI K TAZAWA Y SAKURAI 《Clinical and experimental immunology》1997,107(1):61-67
FITC-labelled IgG obtained from patients convalescing from acute poststreptococcal glomerulonephritis (APSGN) stains glomeruli of patients with early APSGN. We previously reported a streptococcal antigen (preabsorbing antigen (PA-Ag)) that preabsorbed the stain out of sera from the convalescent patients and thus prevented glomerular staining. To confirm the nephritogenicity of PA-Ag, we administered up to 40 mg of this antigen to rabbits for 8 days and observed them for up to 9 weeks. Immunohistological analysis showed diffuse and global glomerular staining for C3 without notable staining for γ-globulin. Light microscopic examinations revealed slight to moderate proliferative glomerulonephritis with exudative change. Control rabbits, which received similar doses of bovine serum albumin, did not show significant staining for C3. A transient and significant decrease in CH50 was observed from weeks 3 to 7 (9.7 ± 0.3 U/ml at week 3; normal range 12.9 ± 0.6 U/ml). This experimental model showed a resemblance to immunological and immunohistological features of APSGN in humans. Although the precise mechanisms are yet to be determined, complement activation by PA-Ag seems to hold a key position in this model and in the human disease. 相似文献
27.
HIROAKI KODAMA YASUYUKI SHIMOHIGASHI TOMMASO COSTA MICHIO KONDO 《Chemical biology & drug design》1988,32(1):41-46
For the elucidation of structural elements in the opiate receptors, a thiol-containing enkephalin analog, [d -Ala2, cysteamine5]enkephalin, and its dimeric analog were synthesized and evaluated in the radio-ligand receptor binding assays using rat brain membranes. The dimeric analog was very potent in both delta and mu assays. Comparison of receptor affinities of the thiol-containing enkephalin with those of standard mu or delta receptor specific ligands suggested that the mu receptor contains an essential thiol group which may interact with the thiol group at the C-terminus of the enkephalin analog. It also appears that no metal-ion site, postulated for the delta receptors, is present in the delta binding site. 相似文献
28.
HATTORI KEN-ICHI; HARADA MINE; YOSHIDA TAKASHI; ISHINO CHIZUKO; FUNADA HISASHI; KODO HIDEKI; MORI TAKAO; MATSUE KOSEI; SHIOBARA SHINTARO; ODAKA KAZUAKL; OHTAKE SHIGEKI; TESHIMA HIROFUMI; KONDO KUNIO; YAMAMURA MAYUMI; NAKAO SHINJI; UEDA MIKIO; NAKAMURA SHINOBU 《Japanese journal of clinical oncology》1982,12(2):171-179
Four patients with advanced non-Hodgkin's lymphoma of unfavorablehistology were treated with marrow-lethal doses of cyclophosphamide(CY) and total body irradiation (TB1) followed by the infusionof cryopreserved autologous marrow. All four patients showedengraftment after autologous bone marrow transplantation andachieved complete remission (CR). Three of them, however, developedrelapse in 1.7, 12.9 and 14.5 mo respectively after the transplantation.The other patient has survived in drug-free CR for more than16.6 mo. There was no treatment-related death although therewere some tolerable complications. These data suggest that theCY-TBI regimen may be effective in inducing CR in patients withadvanced non-Hodgkin's disease but it does not contribute topreventing relapse. 相似文献
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