全文获取类型
收费全文 | 231篇 |
免费 | 11篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 45篇 |
基础医学 | 13篇 |
口腔科学 | 4篇 |
临床医学 | 27篇 |
内科学 | 65篇 |
皮肤病学 | 6篇 |
神经病学 | 12篇 |
外科学 | 43篇 |
综合类 | 3篇 |
预防医学 | 3篇 |
药学 | 10篇 |
肿瘤学 | 10篇 |
出版年
2020年 | 1篇 |
2017年 | 1篇 |
2016年 | 4篇 |
2015年 | 9篇 |
2014年 | 6篇 |
2013年 | 4篇 |
2012年 | 1篇 |
2011年 | 1篇 |
2010年 | 2篇 |
2009年 | 5篇 |
2008年 | 1篇 |
2007年 | 9篇 |
2006年 | 19篇 |
2005年 | 7篇 |
2004年 | 9篇 |
2003年 | 7篇 |
2002年 | 4篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 6篇 |
1998年 | 14篇 |
1997年 | 21篇 |
1996年 | 25篇 |
1995年 | 24篇 |
1994年 | 6篇 |
1993年 | 8篇 |
1992年 | 6篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 5篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1959年 | 1篇 |
1957年 | 2篇 |
1955年 | 2篇 |
1954年 | 1篇 |
1948年 | 1篇 |
排序方式: 共有242条查询结果,搜索用时 15 毫秒
21.
TAKASHI KOBAYASHI TAKASHI KAWAHARA KOJI NISHIZAWA KEIJI OGURA KENJI MITSUMORI YOSHIHIRO IDE 《International journal of urology》2005,12(10):881-885
PURPOSE: To examine value of prostate-speci fi c antigen (PSA) adjusted by prostate volume measured using transabdominal ultrasonography in prostate cancer detection among men with elevated PSA. METHODS: 238 men aged 79 years or younger with serum PSA levels of 2.0-20.0 ng/mL and normal digital rectal examination fi ndings were studied in terms of total and free PSA, prostate volumes with transrectal (TRUS) and transabdominal (TAUS) ultrasonography and transition zone volumes with TRUS prior to transrectal 10-core biopsy. In addition to sole PSA values and the free-to-total PSA ratio, volume-adjusted PSA values, PSA densities determined by TRUS (PSAD(TRUS)), and TAUS (PSAD(TAUS)), and PSA transition zone densities (PSATzD) were compared using receiver operating characteristic (ROC) analysis. RESULTS: Prostate cancer was diagnosed in 58 (24.4%) of the 238 men who underwent prostate biopsies. Of the areas under ROC curves (AUC) of studied parameters, PSATzD (AUC 0.751) was the best and signi fi cantly superior to PSAD(TAUS) (AUC 0.664, P = 0.007). However, PSAD(TAUS) exceeded PSA (AUC 0.559, P = 0.004) and showed potential capability of a one-fourth reduction in unnecessary biopsies without spoiling sensitivity (90%). Cancer detection rate was only 4.2% in the 48 patients whose prostate volume in TAUS was > 50 mL and PSAD(TAUS) was < 0.075. CONCLUSIONS: Since PSAD(TRUS) and PSATzD were signi fi cantly superior to PSAD(TAUS), TRUS is feasible as the standard fashion to determine prostate volume in the diagnosis of prostate cancers. However, TAUS is also worthwhile as it can improve the prostate cancer detection using sole PSA, and primary use of TAUS has the potential to reduce the substantial number of unnecessary biopsy safely. 相似文献
22.
TAKENAO HASEGAWA MASASHI YONEDA KIMIHIDE NAKAMURA KUNIYO OHNISHI HIROYUKI HARADA TAKESHI KYOUDA YOSHIKAZU YOSHIDA ISAO MAKINO 《Journal of gastroenterology and hepatology》1998,13(12):1201-1206
Dumping syndrome commonly occurs after gastrectomy. The late dumping, which is one of the dumping syndromes, is due to postprandial hypoglycaemia caused by an excessive insulin secretion after a sharp rise in plasma glucose. Several treatments, including operation, dietary fibre and somatostatin, have been attempted to relieve dumping symptoms. These treatments take effect through modulation of plasma insulin and glucose levels, but their efficacy is still under consideration. α-Glucosidase inhibitor attenuates the postprandial increase of plasma glucose levels and is widely used for treatment of non-insulin-dependent diabetes mellitus (NIDDM). The acute effect of α-glucosidase inhibitor on late dumping syndrome has been reported by some studies with test meals. The purpose of this study was to evaluate a long-term effect of α-glucosidase inhibitor treatment with ordinary meals in late dumping patients with NIDDM because administration of α-glucosidase inhibitor is only ethically allowed for diabetic patients in Japan. Six late dumping patients with NIDDM were orally administered α-glucosidase inhibitor, acarbose (50 or 100 mg), three times a day before each meal for 1 month. Diurnal changes of plasma glucose, insulin and pancreatic glucagon levels were compared before and after the α-glucosidase inhibitor treatment. All patients had late dumping-related symptoms, such as weakness, palpitation and dizziness before the induction of α-glucosidase inhibitor treatment. Patients suffered from a rapid fall in plasma glucose levels from hyperglycaemia at the same time as dumping symptoms. These late dumping-related symptoms disappeared and a rapid change of plasma glucose and insulin levels were attenuated after the α-glucosidase inhibitor treatment. These data suggest a long-term therapeutic efficacy of α-glucosidase inhibitor for late dumping patients. 相似文献
23.
YUKIFUMI NAWA NAOTO ISHIKAWA KIMIYUKI TSUCHIYA YOICHIRO HORII TATSUYA ABE AZHARUL I. KHAN BING SHI HIROSHI ITOH HISAMITSU IDE FUKUMI UCHIYAMA 《Parasite immunology》1994,16(7):333-338
In the middle of the era of molecular biology, much less attention is paid to in vivo phenomena. However, carefully designed experimental systems in vivo still can provide valuable information as to the mechanisms underlying the establishment and maintenance of host-parasite relationships. In this review we describe the advantage of using concurrent infections with appropriately chosen combinations of different genera or different maturation stages of parasites to segregate the cellular responses of the host. By means of simple experimental approaches we have found that mucosal mast cells and goblet cells, both of which have long been considered as non-specific effectors, are in fact highly selective and specific effector cells of the host defence mechanisms capable of acting on the establishment and the expulsion of intestinal helminths. 相似文献
24.
Concealed Accessory Pathways with a Single Ventricular and Two Discrete Atrial Insertion Sites 下载免费PDF全文
RYAN T. KIPP M.D. RAED ABU SHAM'A M.D. ITO HIROYUKI M.D. FREDERICK T. HAN M.D. MARWAN REFAAT M.D. Ph.D. JONATHAN C. HSU M.D. M.A.S. MICHAEL E. FIELD M.D. DOUGLAS E. KOPP M.D. GREGORY M. MARCUS M.D. M.A.S. MELVIN M. SCHEINMAN M.D. KURT S. HOFFMAYER M.D. 《Pacing and clinical electrophysiology : PACE》2017,40(3):255-263
25.
TETSUO ARAKAWA HAJIME NAKAMURA HIROSHI SATOH TAKASHI FUKUDA HIROYUKI SAKUMA KENZO KOBOYASHI 《Journal of gastroenterology and hepatology》1988,3(5):441-449
The levels of prostaglandin E2 (PGE2 ), 6-keto-prostaglandin F1 α (PGF1 α) and thromboxane B2 (TXB2 ) in endoscopic biopsy specimens from the gastric and duodenal mucosa of healthy volunteers and ulcer patients were measured by radio-immunoassay. The PGE2 and PGF1 α levels in the mucosa of the corpus of the stomach were lower and the TXB2 level was higher in 10 patients with gastric ulcer in the corpus than in the 16 healthy subjects. The PGE2 level in the antral mucosa of 14 patients with gastric ulcer in the antrum was lower than in the controls. In 18 patients with duodenal ulcer, PGE2 deficiency was more widespread in the entire gastric and duodenal mucosa while the reduced PGF1 α level was limited in the gastric corpus. Lower levels of PGE2 in patients with antral or duodenal ulcer and of PGE2 and PGF1 α in patients with corpus ulcer in the anatomical mucosal area including the ulcer site may predispose the mucosa to ulceration. 相似文献
26.
Impact of Non‐Pulmonary Vein Foci on the Outcome of the Second Session of Catheter Ablation for Paroxysmal Atrial Fibrillation 下载免费PDF全文
MASATERU TAKIGAWA M.D. ATSUSHI TAKAHASHI M.D. TAISHI KUWAHARA M.D. KENJI OKUBO M.D. YOSHIHIDE TAKAHASHI M.D. EMIKO NAKASHIMA M.D. YUJI WATARI M.D. KAZUYA YAMAO M.D. JUN NAKAJIMA M.D. KATSUMASA TAKAGI M.D. SHIGEKI KIMURA M.D. HIROYUKI HIKITA M.D. KENZO HIRAO M.D. MITSUAKI ISOBE M.D. 《Journal of cardiovascular electrophysiology》2015,26(7):739-746
27.
Clonal and non-clonal karyotypically abnormal cells in haemophagocytic lymphohistiocytosis 总被引:1,自引:0,他引:1
YASUHIKO KANEKO NOBUO MASEKI MASAHARU SAKURAI MASARU IDO YUKIKO TSDNEMATSU SHUKI MIZUTANI TATSUYA HATTORI HIROYUKI SHIMIZU HARUHIKO EGUCHI TOSHIAKI OKA MUNENORI MIYAKE YASUO HORIKOSHI TAIZAN SUCHI 《British journal of haematology》1995,90(1):48-55
We studied chromosomes in bone marrow (BM) or peripheral blood cells of nine patients with haemophagocytic lymphohistiocytosis (HLH); three of them had a family history of HLH and four others underwent concurrent Epstein-Barr virus (EBV) infection. In addition to a large population of normal mitotic cells, karyotypically abnormal clonal cells were found in two patients, abnormal clonal cells and a nonclonal (single) abnormal cell in one, and nonclonal abnormal cells in three. All the six patients with chromosome abnormalities died of progressive disease; one of them also had EBV infection and EBV-associated clonal proliferation. Two of three patients with EBV infection and only normal mitotic cells in BM completely recovered from the disease.
Although HLH did not show histological and/or haema-tological evidence of a neoplastic disease, clonal chromosome abnormalities and the fatal clinical outcome found in some of the patients suggest that the disease may be heterogenous and include malignancy. HLH patients with karyotypically abnormal clonal cells in BM should warrant more intensive chemotherapy than that presently being applied to them and should be considered as candidates for BM transplantation. 相似文献
Although HLH did not show histological and/or haema-tological evidence of a neoplastic disease, clonal chromosome abnormalities and the fatal clinical outcome found in some of the patients suggest that the disease may be heterogenous and include malignancy. HLH patients with karyotypically abnormal clonal cells in BM should warrant more intensive chemotherapy than that presently being applied to them and should be considered as candidates for BM transplantation. 相似文献
28.
Class IC Antiarrhythmic Drugs, Flecainide and Pilsicainide, Produce ST Segment Elevation Simulating Inferior Myocardial Ischemia 总被引:1,自引:0,他引:1
WAKO NAKAMURA M.D. KAZUHIKO SEGAWA M.D. HIROYUKI ITO M.D. SHUGO TANAKA M.D. NOBUO YOSHIMOTO M.D. 《Journal of cardiovascular electrophysiology》1998,9(8):855-858
ST Elevation with Flecainide and Pilsicainide . Flecainide and pilsicainide, Class IC antiarrhythmic drugs with slow kinetics, were administered to a 64-year-old man experiencing ventricular tachycardia. Both drugs suppressed the arrhythmia, but caused ST segment elevation in leads II, III, and aVF. No evidence of ischemic heart disease was detected. Withdrawal of the drugs eliminated the ST change. Because these drugs frequently are used to treat tachyarrhythmias in patients who may present with chest pain, this rare ECG manifestation of Class IC drugs should he recognized to avoid misdiagnosis of acute interior myocardial infarction. 相似文献
29.
HIROYUKI FUJITA ATSUO MARUTA NAOTO TOMITA JUN TAGUCHI RIKA SAKAI AKIO SHIMIZU MASAOKI HARADA KOUJI OGAWA FUMIO KODAMA TAKAO OKUBO 《British journal of haematology》1995,92(4):947-949
We report the first case of human herpesvirus-6 (HHV-6) associated exanthema in a patient with acute lymphocytic leukaemia (ALL). We analysed DNA extracted from an exanthematous lesion using the polymerase chain reaction (PCR). DNA was positive for HHV-6 but negative for herpes simplex virus, varicella zoster virus, and cytomegalovirus. Immunohistochemical staining of the skin with monoclonal antibody against HHV-6 confirmed the infection. The possibility of HHV-6 infection should be considered when an atypical skin rash is seen in patients with ALL. 相似文献