99Tcm-抗CD20单克隆抗体的制备和动物实验研究

笔者用^99Tc^m标记抗CD20单克隆抗体（抗CD20 McAb），并探讨了其在荷瘤裸鼠体内的生物分布，现报道如下。     

炎症显像剂18F-levofloxacin的标记与动物实验

炎症部位的早期准确定位较困难，有多种放射性药物可用于炎症显像。本研究用^18F标记喹诺酮类抗生素左旋氧氟沙星(levofloxacin)，观察其在动物模型中的生物分布，现报道如下。     

Effects of trazodone hydrochloride and imipramine on polysomnography in healthy subjects

Polysomnography was performed on eight healthy men with trazodone hydrochloride, imipramine and placebo. Trazodone hydrochloride increased slow wave sleep significantly. Imipramine prolonged rapid eye movement (REM) latency and decreased the percentage of REM sleep significantly. Trazodone decreased stages 1 and 2 sleep, while imipramine increased it. These findings suggest that the antidepressive effect of trazodone might be different from that of imipramine with the suppression of REM sleep.     

Giant retroperitoneal liposarcoma

Liposarcomas are one of the most common soft tissue sarcomas of adulthood. Liposarcomas are remarkable because of their frequently large size. We report a case with an extremely large dedifferentiated liposarcoma that weighed 18 kg. Although it was capsulated and could be excised en bloc, the patient suffered a relapse 9 months later and died 1 year after the operation.     

Topographic mapping of electroencephalography coherence in hypnagogic state

Abstract The present study examined the topographic characteristics of hypnagogic electroencephalography (EEG), using topographic mapping of EEG power and coherence corresponding to nine EEG stages (Hori's hypnagogic EEG stages). EEG stages 1 and 2, the EEG stages 3–8, and the EEG stage 9 each correspond with standard sleep stage W, 1 and 2, respectively. The dominant topographic components of delta and theta activities increased clearly from the vertex sharp-wave stage (the EEG stages 6 and 7) in the anterior-central areas. The dominant topographic component of alpha 3 activities increased clearly from the EEG stage 9 in the anterior-central areas. The dominant topographic component of sigma activities increased clearly from the EEG stage 8 in the central-parietal area. These results suggested basic sleep process might start before the onset of sleep stage 2 or of the manually scored spindles.     

CT examination of the head of the Baikal seal (Phoca sibirica)

We carried out a computerised tomographic (CT) examination to elucidate the modifications in the head related to orbital enlargement in the Baikal seal. Transverse CT images showed that (1) the external frontal contours and the frontal sinuses are compressed medially and ventrally by the orbital enlargement; (2) the caudal part of the nasal cavity and nasopharynx are compacted ventrally; and (3) the cranial cavity is displaced caudally. The neurocranium is obviously separated from the facial part in the transverse plane at the caudal region of the orbit. The disposition of the mandible, zygomatic arch, temporal bone, and the masseter, temporal, digastric and pterygoid muscles is changed by the enlarged orbit in the 3-dimensional reorganisation of the head in this species. It is suggested that adaptation for the Lake Baikal environment primarily resulted in orbital enlargement, and that the altered orbital design may subsequently have influenced the form and function of the masticatory and respiratory system.     

Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues

The conformation of pituitary adenylate cyclase activating polypeptide with 27 residues (PACAP27) has been determined by two-dimensional NMR and CD spectroscopies and distance geometry in 25% methanol. Residues 9-20 and 22-25 have well-defined conformations but other residues do not show ordered conformations. The conformation of residues 9-20 is composed of three distinct regions of β turn-like conformation (residues 9-12), α helix (residues 12-14) and the looser helical conformation (residues 15-20), while residues 22-24 form α helix. PACAP27 has a 2 helices separated by a disordered region similar to a VIP analog reported by Fry et al. but is distinct from the VIP analog in the position of the first helix, which is shifted by 2 residues toward the C-terminus, and in the form of the second helix [Fry, D.C., Madison, V.S., Bolin, D.R., Greeley, D.N., Toome, V. and Wegrzynski, B.B. (1989) Biochemistry 28 , 2399-2409].