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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
Laputková G Legin M Sabo J 《Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové》2004,47(4):323-326
The influence of D-glucose on a lipid solid support system with the aid of impedance spectrocopy as a preliminary attempt for the biosensing of medical relevant molecules was studied. In spite of some shortcomings, s-BLM's proved to be an appropriate model for the study of lipid membrane-D-glucose interactions. The shortcomings were the roughness of the metal support, and the lack of homogeneity in the monolayer or multilayer lipid structures. 相似文献
993.
Gil LH Alves FP Zieler H Salcedo JM Durlacher RR Cunha RP Tada MS Camargo LM Camargo EP Pereira-da-Silva LH 《Journal of medical entomology》2003,40(5):636-641
Studies on seasonal anopheline fauna variation were performed in two distinct settlements in the State of Rond?nia, Brazil: one at the Madeira River banks (Portuchuelo) with stable native Amazonian population; the other at an inland lumber-extracting farm (Urupá) in dry land, in which adults are mostly migrants. During a 6-yr period (1994-2000), 8,638 adult anophelines were collected: 2,684 in Urupá and 5,954 in Portuchuelo. Anopheles darlingi represented >95% of total mosquitoes caught. Dissection of 4,424 A. darlingi females yielded a very low sporozoite infection index below 0.1%. Oocysts were found in both localities in approximately 0.1% of dissected mosquitoes. Determination of the hour biting rates disclosed seasonal variations in both localities. However, in Portuchuelo, mosquito density peaked at the acme of the rainy season, whereas at Urupá it peaked in the dry season. The increase in mosquito density and incidence of malaria cases were coincident. The high mosquito densities observed in the riverine settlement of Portochuelo sector B, which permits evaluation in > 10,000 mosquitoes' bites/person/year, could explain, in spite of the low mosquito's infection index, the previously described development of natural immunity in the local population that is not observed in the dry land agroindustrial settlement of Urupá. 相似文献
994.
Adamcová M Sterba M Klimtová I Simůnek T Hrdina R Gersl V Ponka P 《Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové》2003,46(4):171-174
Both cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are considered to be reliable biomarkers with sufficient sensitivity and specificity for cardiac injury in the majority of laboratory animals. The aim of our study was to compare the diagnostic performance of cTnT and cTnI in three groups of rabbits: 1) control (saline 1 ml/kg i.v.); 2) Salicylaldehyde Isonicotinoyl Hydrazone--SIH (50 mg/kg, once weekly, i.p.; partially dissolved in 10% Cremophor solution); 3) 10% Cremophor solution in water (2 ml/kg i.v.). The drugs were given once a week, 10 administrations. The concentration of cTnT was measured using Elecsys Troponin T STAT Immunoassay (Roche). The concentration of cTnI was measured using AxSYM Troponin I (Abbott). The linear regression model was applied to see if there is a dependence between cTnT and cTnI. The coefficient of determination was not acceptable in all groups. The highest value of R2 was found in the control group (R2 = 0.424). We may conclude that in rabbits meaningful dependence between cTnT and cTnI was not found. According to our long-term experiences cTnT seems to be more suitable cardiomarker in rabbits in comparison with cTnI where the data are characterized by the large scatter. 相似文献
995.
996.
J. Moji A. Nicák M. Troák I. Kozák L. Mirossay 《Comparative Haematology International》1999,9(2):83-85
Erythrocyte microrheology changes were measured by cation-osmotic haemolysis (COH) in healthy donors, patients with ischameic
stroke, and patients who died within four days after a stroke. COH in patients with stroke was significantly decreased in
comparison with that from healthy donors. In patients who died, COH was significantly decreased compared to patients who survived.
The relationship between cationosmotic haemolysis and erythrocyte deformability is discussed. 相似文献
997.
E. Knyihár-Csillik János Tajti Mohtasham Samsam Gyula Sáry Péter Buzás László Vécsei 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,118(1):111-114
Electrical stimulation of the Gasserian ganglion resulted in partial depletion of calcitonin gene-related peptide (CGRP) from
ipsilateral central terminals of pseudounipolar primary sensory ganglion cells. Affected terminals exhibit decreased CGRP
immunoreactivity as shown by cytophotometric densitomery of the caudal trigeminal nucleus. The decrease in CGRP immunoreactivity
is statistically significant only in the medial one-third of the caudal trigeminal nucleus. Since earlier studies have shown
that electrical stimulation of the Gasserian ganglion induces first accumulation then depletion of CGRP from perivascular
sensory terminals in the dura mater, the present experiments suggest that CGRP is depleted also from central terminals of
primary sensory trigeminal neurons, which might be of importance in the pathogenesis of migraine headache.
Received: 18 December 1996 / Accepted: 26 June 1997 相似文献
998.
Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels 总被引:6,自引:0,他引:6
Brenda R. Kwak Juan C. Sáez Ronald Wilders Marc Chanson Glenn I. Fishman Elliot L. Hertzberg David C. Spray Habo J. Jongsma 《Pflügers Archiv : European journal of physiology》1995,430(5):770-778
The effects of 8-bromoguanosine 3:5-cyclic monophosphate (8Br-cGMP), a membrane-permeant activator of protein kinase G (PKG), were studied on rat and human connexin43 (Cx43), the most abundant gap junction protein in mammalian heart, which were exogenously expressed in SKHep1 cells. Under dual whole-cell voltage-clamp conditions, 8Br-cGMP decreased gap junctional conductance (gj) in rat Cx43-transfected cells by 24.0±3.7% (mean±SEM, n=5), whereas gj was not affected in human Cx43-transfected cells by the same treatment. The relaxation of gj in response to steps in transjunctional voltage observed in rat Cx43 transfectants was best fitted with three exponentials. Time constants and amplitudes of the decay phases changed in the presence of 8Br-cGMP. Single rat and human Cx43 gap junction channels were resolved in the presence of halothane. Under control conditions, three single-channel conductance states (j) of about 20, 40–45 and 70 pS were detected, the events of the intermediate size being most frequently observed. In the presence of 8Br-cGMP, the
j distribution shifted to the lower size in rat Cx43 but not in human Cx43 transfectants. Immunoblot analyses of Cx43 in subconfluent cultures of rat Cx43 or human Cx43 transfectants showed that 8Br-cGMP did not induce changes in the electrophoretic mobility of Cx43 in either species. However, the basal incorporation of [32P] into rat Cx43 was significantly altered by 8Br-cGMP, whereas this incorporation of [32P] into human Cx43 was not affected. We conclude that 8Br-cGMP modulates phosphorylation of rat Cx43 in SKHep1 cells, but not of human Cx43. This cGMP-dependent phosphorylation of rat Cx43 is associated with a decreased gj, which results from both an increase in the relative frequency of the lowest conductance state and a change in the kinetics of these channels. 相似文献
999.
Itziar Benito-Sánchez Melissa M. Ertl Rosario Ferrer-Cascales Javier Oltra-Cucarella Joaquín A. Ibáñez-Alfonso Mahia Saracostti Schwartzman 《Developmental neuropsychology》2020,45(4):189-199
ABSTRACT To determine the prevalence of low scores on two neuropsychological tests commonly used to evaluate learning and memory in children. 6,030 healthy children from 10 countries in Latin America and Spain were administered Rey–Osterrieth Complex Figure (ROCF) and the Test de Aprendizaje y Memoria Verbal–Infantil (TAMV-I). Results showed that low scores are common when multiple neuropsychological outcomes (tests and/or scores) are evaluated in healthy individuals. Clinicians should consider the higher probability of low scores in a given individual when evaluating learning and memory using various sets of scores to reduce false-positive diagnoses of cognitive deficits in pediatric populations. 相似文献
1000.
Lactate and pyruvate increase the incorporation of [3H]proline into collagen [3H]hydroxyproline in liver slices of CCl4 cirrhotic rats 总被引:1,自引:0,他引:1
J Cerbón-Ambriz J Cerbón E González M Rojkind 《Laboratory investigation; a journal of technical methods and pathology》1987,57(4):392-396
Lactate and pyruvate enhanced the incorporation of [3H]proline into collagen [3H]hydroxyproline when added to liver slices of CCl4-treated rats. In addition, pyruvate stimulated the accumulation of cAMP, reaching maximum values after 10 minutes of incubation. Similar results were obtained with newborn rat calvariae, a tissue that normally produces large amounts of type I collagen. In normal liver, which produces relatively small amounts of collagen, lactate had no effect on cAMP levels or collagen synthesis. Pyruvate stimulated the accumulation of cAMP, but had no effect on collagen synthesis. These results indicate that different control mechanisms are involved in regulation of collagen biosynthesis in normal as compared with cirrhotic liver; the latter resembling mesenchymal tissues specialized in collagen production such as newborn rat calvariae. 相似文献