全文获取类型
收费全文 | 258篇 |
免费 | 23篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 14篇 |
妇产科学 | 3篇 |
基础医学 | 27篇 |
口腔科学 | 7篇 |
临床医学 | 36篇 |
内科学 | 39篇 |
皮肤病学 | 6篇 |
神经病学 | 18篇 |
特种医学 | 36篇 |
外科学 | 28篇 |
综合类 | 33篇 |
预防医学 | 8篇 |
眼科学 | 3篇 |
药学 | 6篇 |
中国医学 | 1篇 |
肿瘤学 | 17篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 6篇 |
2021年 | 3篇 |
2020年 | 6篇 |
2019年 | 3篇 |
2018年 | 7篇 |
2017年 | 4篇 |
2016年 | 3篇 |
2015年 | 12篇 |
2014年 | 10篇 |
2013年 | 5篇 |
2012年 | 11篇 |
2011年 | 9篇 |
2010年 | 11篇 |
2009年 | 6篇 |
2008年 | 10篇 |
2007年 | 13篇 |
2006年 | 18篇 |
2005年 | 13篇 |
2004年 | 8篇 |
2003年 | 5篇 |
2002年 | 4篇 |
2001年 | 10篇 |
2000年 | 5篇 |
1999年 | 8篇 |
1998年 | 9篇 |
1997年 | 7篇 |
1996年 | 16篇 |
1995年 | 13篇 |
1994年 | 5篇 |
1993年 | 8篇 |
1992年 | 1篇 |
1991年 | 5篇 |
1989年 | 7篇 |
1988年 | 2篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1977年 | 1篇 |
1975年 | 2篇 |
排序方式: 共有283条查询结果,搜索用时 562 毫秒
131.
Helga Agustsdottir Holmfridur Gudmundsdottir Hafsteinn Eggertsson Stefan Hrafn Jonsson Jon Oskar Gudlaugsson Sigurdur Runar Saemundsson Sigfus T. Eliasson Inga B. Arnadottir W. Peter Holbrook 《Community dentistry and oral epidemiology》2010,38(4):299-309
Agustsdottir H, Gudmundsdottir H, Eggertsson H, Jonsson SH, Gudlaugsson JO, Saemundsson SR, Eliasson ST, Arnadottir IB, Holbrook WP. Caries prevalence of permanent teeth: a national survey of children in Iceland using ICDAS. Community Dent Oral Epidemiol 2010; 38: 299–309. © John Wiley & Sons A/S Abstract – Objectives: The Icelandic Oral Health Survey aimed to obtain new national data on the oral health of Icelandic children and teenagers. Methods: A representative stratified random cluster sample of 2251 Icelandic children in first, seventh and 10th grade, aged approximately 6‐, 12‐ and 15‐years old was examined for caries prevalence using the ICDAS criteria. Bite‐wing digital radiographs were obtained for the children in 7th and 10th grade. Results: D3MFT scores by visual examination of 6‐, 12‐ and 15‐year olds were 0.12, 1.43 and 2.78 respectively but when including radiographs, the D3MFT rose to 2.11 at 12 years and 4.25 at 15 years. The Significant Caries Index, SiC, by visual examination for 12 and 15 y was 3.7 and 6.7 respectively but was 4.7 for 12 y and 8.9 for 15 y with radiographs. In all age groups and at most disease levels, caries was active in the majority of the lesions (58–100%). The percentage of children with no visually detectable caries at D3/D1 level was 93%/74% for 6 years, 48%/22% for 12 years and 35%/16% for 15 years. When radiographs were included the percentage reduced to 34%/15% for 12 years and 20%/6% for 15 years. Approximately 80% of 12‐ and 15‐year‐olds had at least one of their first molars sealed, with the mean number of sealed first molars being 2.2 among 12 y and 2.0 among 15 y. Conclusions: Caries levels were higher than expected in this national survey and further away from the goals of the National Health Plan for 2010 than anticipated. Caries distribution was skewed with more than half of the children having low caries scores but a wide distribution of caries experience was seen among the remaining population. 相似文献
132.
133.
Amstadter AB Elwood LS Begle AM Gudmundsdottir B Smith DW Resnick HS Hanson RF Saunders BE Kilpatrick DG 《Addictive behaviors》2011,36(8):814-820
Exposure to interpersonal victimization during childhood and adolescence is prevalent and has been found to be associated with negative physical and mental health outcomes. The present study examined the relations between childhood violence exposure and mental health on subsequent exposure to new physical assault in young adults using longitudinal nationally representative, prospective data from the initial (Wave I) and follow-up interviews (Wave II) of the National Survey of Adolescents (NSA). Among the 1,753 participants who completed both assessment time points, 15.8% reported a new physical assault experience at Wave II. Results indicated that racial/ethnic status, gender, history of child physical abuse, witnessed violence drug use, and family drug problems reported at Wave I were all significant predictors of new physical assault. Implications are discussed. 相似文献
134.
S Narayan KS Rana M Sharma RK Sharma P Talwar K Kapur BK Goyal 《Medical Journal Armed Forces India》2010
Introduction: The Army Hospital (R&R) is the only service hospital providing in-vitro fertilisation (IVF) facility. Neonatal characteristics of live-born infants at this centre over a two-year period are analyzed in this study. 相似文献
135.
Strand AH Gudmundsdottir H Fossum E Os I Bjørnerheim R Kjeldsen SE 《Journal of clinical hypertension (Greenwich, Conn.)》2007,9(5):365-371
Left ventricular (LV) hypertrophy is related to blood pressure level and neurohormonal factors. The authors previously demonstrated that arterial norepinephrine levels predict LV mass in middle-aged men who developed hypertension through 20 years. The aim of this 20-year prospective study was to investigate arterial vasopressin, aldosterone, and renin as long-term predictors of LV mass. Normotensives (n=17), subjects who developed hypertension (n=17), and sustained hypertensives (n=22) were compared at baseline (42 years) and at follow-up (62 years). There were no significant differences in baseline vasopressin, aldosterone, or renin levels. The group with sustained hypertension had more LV hypertrophy (P=.025) at follow-up. Among new hypertensives, multiple regression analysis demonstrated that baseline arterial vasopressin (beta-0.53; P=.041) and aldosterone (beta-0.56;P=.032) independently explained LV mass index (R(2)=0.85; P=.035). In conclusion, baseline arterial vasopressin and aldosterone, but not renin, appear to predict LV mass in middle-aged men who developed hypertension over a 20-year period. 相似文献
136.
<Emphasis Type="Italic">FGFR1</Emphasis> amplification in breast carcinomas: a chromogenic <Emphasis Type="Italic">in situ</Emphasis>hybridisation analysis 总被引:3,自引:1,他引:2 下载免费PDF全文
Elbauomy Elsheikh S Green AR Lambros MB Turner NC Grainge MJ Powe D Ellis IO Reis-Filho JS 《Breast cancer research : BCR》2007,9(2):R23
Background
The amplicon on 8p11.2 is reported to be found in up to 10% of breast carcinomas. It has been demonstrated recently that this amplicon has four separate cores. The second core encompasses important oncogene candidates, including the fibroblast growth factor receptor 1 (FGFR1) gene. Recent studies have demonstrated that specific FGFR1 amplification correlates with gene expression and that FGFR1 activity is required for the survival of a FGFR1 amplified breast cancer cell line. 相似文献137.
Background
Hysteroscopic surgery requires pre-operative cervical ripening to facilitate adequate dilatation of the cervix for insertion of operative hysteroscope. This study was conducted to compare the efficacy of intracervical misoprostol with vaginal misoprostol in achieving cervical ripening before operative hysteroscopy.Methods
In this randomised comparative study conducted at a tertiary care teaching hospital, 56 patients needing operative hysteroscopy were divided into two groups of 28 patients, one for intracervical misoprostol and the other for vaginal misoprostol. Four hundred microgram of misoprostol was inserted on the night before and in the morning of operative hysteroscopy intracervically in group I and vaginally in group II.Results
Primary outcome measure was number of patients achieving 7 mm preoperative dilatation of cervix. Largest Hegar dilator that could be passed into the uterine cavity past the internal optic sheath without resistance was noted in each case. Mean cervical dilatation prior to operative hysteroscopy was calculated. In addition, incidence of slipping of vulsellum and cervical laceration was also noted. Time to achieve full cervical dilatation was recorded. In 23/28 cases of group I and 5/28 in group II, size 7 Hegar dilator could be passed without effort. Mean cervical dilatation was 7.5 mm in group I and 5.7 mm in group II. Slipping of the vulsellum and cervical lacerations were seen in significantly less patients in group I. Mean time to achieve cervical dilatation to 10 mm was 43.39 seconds in group I and 103.96 seconds in group II (P<0.0001).Conclusion
Intracervical administration of misoprostol is an effective method of achieving cervical ripening for easy cervical dilatation up to 10 mm prior to operative hysteroscopy. 相似文献138.
Strand AH Gudmundsdottir H Os I Smith G Westheim AS Bjørnerheim R Kjeldsen SE 《Journal of hypertension》2006,24(5):905-913
BACKGROUND: Increased sympathetic activity may be an underlying mechanism in cardiovascular disease. It has been hypothesized that the degree of left ventricular (LV) hypertrophy is partly related to the blood pressure level, and partly to neurohormonal factors. The aim of this study was to investigate predictors of LV mass, including arterial plasma noradrenaline as an index of sympathetic activity, with particular emphasis on subjects who developed hypertension over a period of 20 years. METHODS: In a 20-year prospective study of middle-aged men, sustained hypertensives (n = 22), new hypertensives (crossovers) (n = 17) and sustained normotensives (controls) (n = 17) were examined both at baseline and after 20 years of follow-up (at ages 42.1 +/- 0.5 and 62.3 +/- 0.6 years, respectively). Relationships between arterial plasma catecholamines, blood pressure and body mass index at baseline to left ventricular parameters by echocardiography at follow-up were investigated. RESULTS: Groups were homogeneous regarding age, gender, race and body build. The group of sustained hypertensives had significantly more LV hypertrophy (P = 0.025) and diastolic dysfunction (P = 0.010). Among the crossovers, LV mass index was positively correlated to arterial plasma noradrenaline (r = 0.50, P = 0.043) and body mass index (BMI) (r = 0.51, P = 0.039) and showed a positive trend with systolic blood pressure (SBP) at baseline. Arterial plasma noradrenaline (beta = 0.47) was found to predict LV mass index after 20 years independently of BMI (beta = 0.45) and SBP (beta = 0.22) at baseline (R adjusted = 0.345, P = 0.037). Such a relationship was not found in the controls or in the sustained hypertensives, of which 16 were treated with antihypertensive drugs. CONCLUSIONS: Arterial plasma noradrenaline at baseline, as an index of sympathetic activity, predicts LV mass at follow-up independently of systolic blood pressure and body build in middle-aged men who developed hypertension over a period of 20 years. 相似文献
139.
140.
Gunnar Sigurdsson Nikulas Sigfusson Inga Ingibj?rg Gudmundsdottir Uggi Agnarsson Helgi Sigvaldason Vilmundur Gudnason 《European journal of cardiovascular prevention and rehabilitation》2004,11(2):121-124
BACKGROUND: To do a gender comparison of absolute risk of recurrent myocardial infarction (MI). DESIGN: Registration of all first and second MI amongst Icelandic males and females 1981-1999. METHODS: The whole of Icelandic population, 40-74 years of age. RESULTS: The mean recurrence rate (second attack) for men was 45.7/1000 MI survivors/year and for women 39.0/1000 per year. The male/female (M/F) ratio was 1.17, 95% confidence interval 1.00-1.37, P = 0.05 and did not change significantly with age. The M/F ratio for first MI in comparison was two to seven, lowest in the oldest group. The recurrence rate decreased significantly and similarly in both sexes during the observation period. CONCLUSION: The absolute risk of MI is closely similar amongst both sexes and has decreased similarly suggesting that the same kind of secondary intervention is effective amongst both sexes in a general population. 相似文献