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991.
992.
993.
Progressive multifocal leukoencephalopathy (PML) occurs in patients with profound immunosuppression. Although lesions are usually devoid of lymphoplasmocytic infiltrates, inflammatory forms of PML have been described, in both human immunodeficiency virus (HIV)-seropositive (HIV+) and-seronegative (HIV?) patients. In addition, PML has been shown to develop in HIV+ patients shortly after introduction of highly active antiretroviral therapy (HAART), despite a recovery of the immune system. Therefore, one could postulate that PML might arise in the context of an immune reconstitution syndrome. To examine the clinical and neuroradiological characteristics of inflammatory forms of PML, the authors performed a retrospective analysis of the patients seen at their institution since 1996 as well as a review of the literature. Of 39 HIV+ and HIV?PML patients, 5 (13%) presented with an inflammatory form of this disease. Two HIV+ patients developed PML soon after the onset of HAART, concomitant to immune recovery, as demonstrated by a decrease of HIV viral load (VL) and an increase of CD4+ T-cell count. Three patients (2 HIV+ and 1 HIV?) had signs of inflammation in the central nervous system (CNS) characterized by contrast-enhancing lesions on neuroimaging studies, and/or inflammatory infiltrates on brain biopsy. The presence of JC virus-specific cytotoxic T lymphocytes was demonstrated in 4/4 patients tested and the outcome was favorable in 3 of them. In agreement with previously published case reports, the data indicate that inflammatory reactions in PML are not infrequent, and that they are generally associated with a favorable prognosis. Therefore clinicians should not disregard the diagnosis of PML in presence of contrast-enhancing brain lesions, and should use caution before treating these immunosuppressed individuals with steroids. 相似文献
994.
对71例肾移植术后患者进行了氨苄青霉素与环孢菌素的相互作用研究。患者在开始服用氨苄青霉素之前、之中、之后的肾功能以及环孢菌素全血浓度测定结果表明,三项指标均无显著改变。另一组肾移植术后患者37例进行的诺氟沙星与环孢菌素相互作用研究,结果与氨苄青霉素的相互作用类似。提示氨苄青霉素、诺氟沙星可安全地与环孢菌素合用,而不影响肾功能。 相似文献
995.
Bioelectricity of the affected muscles at acute stage, recovery stage and sequel state in 93 cases of peripheral facial paralysis was observed with EMG. Pathological potential or motor potential was found to be reduced to varying degrees in all the affected muscles. After treatment by point-through-point acupuncture, myodynamia recovered fairly rapidly, EMG showed obvious changes, pathological potential decreased, and the normal motor unit potential increased remarkably. Comparative analysis of EMG before and after acupuncture indicated that point-through-point acupuncture had an obvious therapeutic effect on the disease. It was also very significant that EMG was used in diagnosing various stages of peripheral facial paralysis, evaluation of prognosis and guidance in clinical treatment. 相似文献
996.
十二指肠溃疡生活事件及社会支持的对照研究 总被引:8,自引:1,他引:7
目的 探讨十二指肠溃疡与生活事件及社会支持的关系。方法 采用生活事件量表(LES),社会支持评定量表(SSRS)对十二指肠溃疡患者(58例)与健康对照(67例)进行问卷测试与评价分析。结果 十二指肠溃疡患者在生活事件里正性刺激量,负性刺激量和总刺激量都明显高于健康对照组,十二指肠溃疡患者受到的主观支持比一般人群多;而客观支持比一般人群少,但十二指肠溃疡患者受到的总支持量并不比一般人多,而且,十二指肠溃疡患者对支持的利用度也不比一般人高。结论 十二指肠溃疡患者有明显的生活事件和不足的社会支持,对生活事件的刺激尤为敏感。 相似文献
997.
Background: We describe a technique of laparoscopic cecal ligation and puncture (CLP) in the rat analogous to open CLP which may facilitate
the study of minimally invasive surgery (MIS) and peritonitis.
Methods: Forty-four rats were randomized to either laparoscopic or open CLP and their 3-day mortality was recorded. Autopsies were
performed for peritoneal fluid cultures, measurement of the length of ligated cecum, and scoring of the degree of cecal necrosis.
Results: Laparoscopic CLP required slightly longer operating times compared to open CLP (average 15.6 vs 13.1 min, p= 0.002). Three-day postoperative mortality was 36.4% and 22.7% for open and laparoscopic CLP, respectively (p= NS). There were no differences in the length of ligated cecum or the cecal necrosis score between the open and laparoscopic
CLP groups.
Conclusion: Laparoscopic CLP is feasible and produces a fecal peritonitis with similar characteristics to those of traditional open CLP.
Received: 3 July 1996/Accepted: 7 January 1997 相似文献
998.
丁基苯酞对大鼠局灶性脑缺血和重灌后脑内TXB2和6—keto—PGF1α… 总被引:8,自引:2,他引:6
目的:观察丁基苯酞(NBP)对大鼠局灶性脑缺血及重灌后海马,纹状体和皮层中TXB2及6-keto-PGF1α含量的影响,方法:尼龙线栓塞法造成大鼠局灶性脑缺血模型,TXB2和6-keto-PGF1α用放免法测定。结果:NBP10mg.kg^-1治疗对缺血重灌注后脑组织中TXB2的产生具有抑制作用,但对6-keto-PGF1α的产生无明显作用,NBP20mg.kg^-1治疗后,重灌5min缺血脑组织 相似文献
999.
目的 观察环孢素血药浓度与肾移植效果间关系。方法 对97例接受同种异体肾脏移植术受者术后8周内206例次环孢素血药浓度监测结果进行回顾性分析,按照受者术后的临床表现、生化指标将其分为术后正常组、急性排斥组、急性毒性组,采用荧光偏振免疫测定法,以单克隆抗体试剂测定环孢素血药浓度。结果 术后正常组62例移植肾功能良好,环孢素的给药剂量为52±1.9 mg/kg·d,171例次环孢素血药浓度的平均值为309.85±131.69μg/L;术后急性排斥组 26例,距发生排斥反应最近一次的环孢素血药浓度平均为165.80±123.13μg/L,环孢素的给药剂量为 4.8±1.6mg/kg·d;术后急性毒性组9例,距发生毒性反应最近一次的环孢素血药浓度平均为556.51±102.50μg/L,环孢素的给药剂量为6.2±1.0mg/kg·d。三组之间环孢素的给药剂量无显著性差异(P>0.05),但环孢素血药浓度却相差很大,两两之间有显著性差异(正常组与排斥组 P< 0.05;正常组与毒性组P< 0.05;排斥组与毒性组P< 0.01)。结论 环孢素浓度较低时,出现排斥反应的可能性较大;而环孢素浓度较高时,发生毒性反应的机会较多。 相似文献
1000.
Isha Tyagi H. C. Taneja 《Indian journal of otolaryngology and head and neck surgery》1997,49(1):51-53
A 50-year old male presented with swollen right eyelids, bleeding per nostrils and a vague left post-auricular swelling for 4 months. Posterior rhinoscopy revealed one pinkish polypoidal mass in the posterior nare and roof of nasopharynx. FNAC from the post-auricular swelling suggested metastatic undifferentiated carcinoma. Incisional biopsy was done form the nasopharynx and histopathological examination proved it to be a malignant paraganglioma. The case is reported for its rarity. 相似文献