全文获取类型
收费全文 | 1600篇 |
免费 | 159篇 |
国内免费 | 61篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 76篇 |
妇产科学 | 15篇 |
基础医学 | 210篇 |
口腔科学 | 41篇 |
临床医学 | 275篇 |
内科学 | 427篇 |
皮肤病学 | 20篇 |
神经病学 | 103篇 |
特种医学 | 102篇 |
外科学 | 161篇 |
综合类 | 46篇 |
预防医学 | 129篇 |
眼科学 | 47篇 |
药学 | 106篇 |
中国医学 | 2篇 |
肿瘤学 | 58篇 |
出版年
2021年 | 14篇 |
2019年 | 22篇 |
2018年 | 20篇 |
2017年 | 22篇 |
2016年 | 22篇 |
2015年 | 29篇 |
2014年 | 37篇 |
2013年 | 91篇 |
2012年 | 86篇 |
2011年 | 70篇 |
2010年 | 64篇 |
2009年 | 60篇 |
2008年 | 95篇 |
2007年 | 116篇 |
2006年 | 81篇 |
2005年 | 80篇 |
2004年 | 50篇 |
2003年 | 43篇 |
2002年 | 56篇 |
2001年 | 32篇 |
2000年 | 42篇 |
1999年 | 35篇 |
1998年 | 45篇 |
1997年 | 49篇 |
1996年 | 33篇 |
1995年 | 26篇 |
1994年 | 38篇 |
1993年 | 33篇 |
1992年 | 26篇 |
1991年 | 29篇 |
1990年 | 17篇 |
1989年 | 32篇 |
1988年 | 24篇 |
1987年 | 24篇 |
1986年 | 16篇 |
1985年 | 15篇 |
1984年 | 11篇 |
1983年 | 11篇 |
1982年 | 15篇 |
1981年 | 16篇 |
1980年 | 11篇 |
1979年 | 14篇 |
1978年 | 10篇 |
1977年 | 11篇 |
1976年 | 13篇 |
1975年 | 12篇 |
1972年 | 7篇 |
1971年 | 8篇 |
1970年 | 9篇 |
1937年 | 8篇 |
排序方式: 共有1820条查询结果,搜索用时 0 毫秒
71.
72.
This, the fifth and final article in the series, addresses the diagnoses and treatment of problems which may arise following provision of removable partial dentures (RPDs). These include difficulties seating the denture, pain and discomfort, looseness and functional problems. 相似文献
73.
Pickett-Schenk SA Cook JA Grey D Banghart M Rosenheck RA Randolph F 《Community mental health journal》2002,38(3):199-211
This study examined the work histories of 7,228 homeless persons with mental illness who were enrolled into the multi-site Access to Community Care and Effective Services and Supports (ACCESS) research demonstration program. Multiple logistic regression analyses suggest that use of vocational services is significantly associated with increased likelihood of paid employment. The role of vocational rehabilitation services in removing persons from homelessness and improving their quality of life is discussed. 相似文献
74.
75.
Lucas Trigler R Grey Weaver James W O'Neil Michael J Barondes Sharon F Freedman 《Journal of AAPOS》2005,9(1):17-21
PURPOSE: Laser photocoagulation is the current treatment standard for severe retinopathy of prematurity (ROP). Uncommon, but well recognized complications include cataract, and vitreous and retinal hemorrhage. Angle-closure glaucoma after laser photocoagulation for ROP is rare. The purpose of this study was to identify additional cases of angle-closure glaucoma following laser treatment for ROP. METHODS: Five eyes of four patients with angle-closure glaucoma following laser treatment for ROP were identified by three ophthalmologists at separate institutions between 1997 and 2001. Demographic and clinical data were obtained from medical records. Clinical and surgical findings associated with the diagnosis and management of angle-closure glaucoma following ROP laser were evaluated. RESULTS: The following data were collected (mean (range)): gestational age, 26.8 (24 to 29) weeks; birth weight, 833 (570 to 1062) g; age at laser treatment for ROP, 35 (33 to 37) weeks; number of laser burns, 1598 (930 to 2400); and time to diagnosis of angle-closure glaucoma, 3.6 (2 to 5) weeks. Three of five eyes had objective data for intraocular pressure (IOP) and corneal diameter with mean IOP 41 mm Hg (35 to 44) and mean corneal diameter 11.1 mm (10.25 to 11.5). Initial treatment included topical and systemic medications. Three eyes required surgical intervention. Angle-closure resolved in all cases with normalization of IOP. Follow-up (5 months to 3.6 years) showed that affected eyes tended to be more myopic than unaffected fellow eyes (mean spherical equivalent -6.5 vs -4.7 diopters). CONCLUSIONS: Angle-closure glaucoma can develop following laser treatment for severe ROP. Medical, and frequently surgical, intervention provides effective management. 相似文献
76.
Laybutt R Hasenkamp W Groff A Grey S Jonas JC Kaneto H Sharma A Bonner-Weir S Weir G 《Diabetes》2001,50(Z1):S180-S181
77.
78.
Phorbol ester-sensitive EL4 murine thymoma cells respond to phorbol 12-
myristate 13-acetate with activation of ERK mitogen-activated protein
kinases, synthesis of interleukin-2, and death, whereas phorbol ester-
resistant variants of this cell line do not exhibit these responses.
Additional aspects of the resistant phenotype were examined, using a
newly-established resistant cell line. Phorbol ester induced morphological
changes, ERK activation, calcium-dependent activation of the c-Jun
N-terminal kinase (JNK), interleukin-2 synthesis, and growth inhibition in
sensitive but not resistant cells. A series of protein kinase C activators
caused membrane translocation of protein kinase C's (PKCs) alpha, eta, and
theta in both cell lines. While PKC eta was expressed at higher levels in
sensitive than in resistant cells, overexpression of PKC eta did not
restore phorbol ester-induced ERK activation to resistant cells. In
sensitive cells, PKC activators had similar effects on cell viability and
ERK activation, but differed in their abilities to induce JNK activation
and interleukin-2 synthesis. PD 098059, an inhibitor of the mitogen
activated protein (MAP)/ERK kinase kinase MEK, partially inhibited ERK
activation and completely blocked phorbol ester-induced cell death in
sensitive cells. Thus MEK and/or ERK activation, but not JNK activation or
interleukin-2 synthesis, appears to be required for phorbol ester-induced
toxicity. Alterations in phorbol ester response pathways, rather than
altered expression of PKC isoforms, appear to confer phorbol ester
resistance to EL4 cells.
相似文献
79.
HM Karaka F Tokoglu M Kacar S Boyacigil 《Journal of Medical Imaging and Radiation Oncology》1997,41(2):179-180
A 54-year-old man with a unilocular hydatid cyst within the infero-posterior angle of the orbit and a 6-year-old male child with a unilocular hydatid cyst within the supero-medial angle of the orbit are presented. The retrobulbar cysts were diagnosed with computed tomography and ultrasonography and were treated after serologic confirmation. 相似文献
80.
HM Goodyear JC Moore-Gillon EH Price VF Larcher MO Savage CB Wood 《Archives of disease in childhood》1993,69(2):229-231
Childhood tuberculosis is perceived by many as a disease of the past. Experience in a children's hospital serving a deprived population suggested that tuberculosis and other mycobacterial infections were not declining in clinical practice. Fifty three tuberculous and 11 atypical mycobacterial infections were identified between 1978 and 1992. There was no decline in tuberculosis and nine of the 11 atypical infections occurred in the last five years. Altogether 40% of cases of tuberculosis were in non-Asian children; 32% had arrived in the UK or visited family overseas in the previous year; and 38% had a history of tuberculosis contact, usually a close adult relative. Nationally, the previous decline in tuberculosis in all ages has reversed. In the local health districts in London's east end, childhood tuberculosis has also stopped declining and seems to be increasing. It is regrettable that BCG vaccination has been abolished by some districts in the UK, against current recommendations. Childhood tuberculosis is still common in the practice described here, including among children who do not fall into conventionally recognised high risk groups. Inner city dwellers and junior doctors are both highly mobile populations, adding to the risk that paediatricians, particularly those in training, may encounter tuberculosis with little or no previous experience of the condition. 相似文献