全文获取类型
收费全文 | 242篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 10篇 |
妇产科学 | 3篇 |
基础医学 | 36篇 |
口腔科学 | 9篇 |
临床医学 | 13篇 |
内科学 | 33篇 |
皮肤病学 | 3篇 |
神经病学 | 5篇 |
特种医学 | 59篇 |
外科学 | 14篇 |
综合类 | 11篇 |
预防医学 | 10篇 |
眼科学 | 9篇 |
药学 | 24篇 |
中国医学 | 1篇 |
肿瘤学 | 12篇 |
出版年
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 5篇 |
2016年 | 4篇 |
2014年 | 4篇 |
2013年 | 11篇 |
2012年 | 4篇 |
2011年 | 3篇 |
2010年 | 5篇 |
2009年 | 11篇 |
2008年 | 6篇 |
2007年 | 6篇 |
2006年 | 2篇 |
2005年 | 6篇 |
2004年 | 2篇 |
2001年 | 3篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 8篇 |
1997年 | 12篇 |
1996年 | 12篇 |
1995年 | 12篇 |
1994年 | 10篇 |
1993年 | 14篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 9篇 |
1988年 | 14篇 |
1987年 | 13篇 |
1986年 | 10篇 |
1985年 | 5篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 3篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 2篇 |
1960年 | 1篇 |
排序方式: 共有252条查询结果,搜索用时 15 毫秒
21.
22.
BACKGROUND: Brainstem gliomas are highly heterogeneous tumors both in their clinical manifestation and in their pathology. Despite significant advances in the surgery for brainstem gliomas many aspects of this pathology are still unelear. OBJECTIVE: To evaluate the clinical, radiological and surgical outcome of 40 focal "intrinsic" brainstem gliomas and propose a surgical strategyoriented classification. MATERIALS AND METHODS: A total of 40 focal ‘intrinsie’ ("expanding variety") tumors have been operated over a period of 8.5-years (January 1998-June 2007). Our criteria included patients with (1) well-defined gadolinium enhancing tumor, (2) relatively long duration of symptoms (〉 six months) and (3) good neurological functional status and independent for all activities of davy living. The cutoff size of 2 cm was not rigidly adhered to. RESULTS: The "intrinsic" brainstem tumors were classified into three types: Expanding, diffuse infiltrative and pure ventral varieties. 相似文献
23.
24.
25.
Krutchen AE; Bjarnason H; Stackhouse DJ; Nazarian GK; Magney JE; Hunter DW 《Radiology》1996,200(1):159
26.
27.
Dimitry A. Chistiakov Alexandra A. Melnichenko Andrey V. Grechko Veronika A. Myasoedova Alexander N. Orekhov 《Experimental and molecular pathology》2018,104(2):114-124
Chronic inflammation is a central pathogenic mechanism of atherosclerosis induction and progression. Vascular inflammation is associated with accelerated onset of late atherosclerosis complications. Atherosclerosis-related inflammation is mediated by a complex cocktail of pro-inflammatory cytokines, chemokines, bioactive lipids, and adhesion molecules, and blocking the key pro-atherogenic inflammatory mechanisms can be beneficial for treatment of atherosclerosis. Therapeutic agents that specifically target some of the atherosclerosis-related inflammatory mechanisms have been evaluated in preclinical and clinical studies. The most promising anti-inflammatory compounds for treatment of atherosclerosis include non-specific anti-inflammatory drugs, phospholipase inhibitors, blockers of major inflammatory cytokines, leukotrienes, adhesion molecules, and pro-inflammatory signaling pathways, such as CCL2-CCR2 axis or p38 MAPK pathway. Ongoing studies attempt evaluating therapeutic utility of these anti-inflammatory drugs for treatment of atherosclerosis. The obtained results are important for our understanding of atherosclerosis-related inflammatory mechanisms and for designing randomized controlled studies assessing the effect of specific anti-inflammatory strategies on cardiovascular outcomes. 相似文献
28.
Cyclic neutropenia (CN): a clue to the control of granulopoiesis 总被引:2,自引:0,他引:2
A simple quantitative feedback model of granulopoiesis is presented and discussed within the framework of existing data on granulopoiesis in both normals and patients with cyclic neutropenia (CN). The model assumes that the controlled compartment is the bone marrow pool of mature neutrophils (PMNs), which sends a negative feedback signal to the mitotic pool of early granulocyte precursors (i.e., CFU-C, myeloblasts, etc.) thus controlling the granulocyte production rate. Three parameters are found to play important roles in determining the response of the system to perturbations. These are: TM, the granulocyte maturation time; a, a parameter reflecting the strength of the negative feedback exerted by mature PMNs on the granulocyte production rate; and b, a parameter describing the leakiness of the bone marrow for PMN egress. It is shown that depending on the relative magnitudes of a and b, the system will either respond to perturbations with a damped oscillation (a less than b: the normal state) or with a sustained oscillation (a greater than b: the CN state). In both cases, the oscillation period is found to approximately equal 2TM. Deductions of the values of a, b, and TM from experimental data are consistent with the predictions of the model and show an increased value of a in CN relative to the normal state. This suggests an overly active feedback mechanism as the pathophysiologic basis of CN. In addition, the model can explain how various therapeutic agent correct CN and also provides insight into why other hematologic cell lines and CSA oscillate in CN. 相似文献
29.
Weinberg JB; Misukonis MA; Shami PJ; Mason SN; Sauls DL; Dittman WA; Wood ER; Smith GK; McDonald B; Bachus KE 《Blood》1995,86(3):1184-1195
30.