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61.
62.
Renal localization of gallium-67 citrate 总被引:1,自引:0,他引:1
63.
Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection 总被引:11,自引:5,他引:6
Spandorfer SD; Avrech OM; Colombero LT; Palermo GD; Rosenwaks Z 《Human reproduction (Oxford, England)》1998,13(2):334-338
The purpose of this study was to investigate any influence of maternal
and/or paternal age on gamete characteristics and pregnancy outcomes in
intracytoplasmic sperm injection (ICSI) cycles. In all, 821 consecutive
ICSI cases were analysed retrospectively. While a significant linear
decline in semen volume was detected, no significant differences in the
concentration, motility or morphology of the spermatozoa were found with
paternal ageing. A significant decline in the number of oocytes retrieved
and the number of mature oocytes obtained was found with advancing maternal
age. An increase in the occurrence of digyny was noted with parental
ageing, while no difference in single or bipronuclear fertilization was
found. Older women had a decreased incidence of single pronucleus formation
and an increase in digyny, but no significant difference in the percentage
of oocytes that underwent two-pronuclear fertilization was detected with
regard to maternal ageing. Pregnancy outcomes were not influenced by the
age of the male partner, while a strong negative correlation was found with
maternal ageing. To better analyse male partner ageing as a factor
affecting pregnancy outcome, we analysed a subgroup of patients with a
female partner aged <35 years who underwent ICSI. No paternal influence
on ICSI pregnancy outcome was found in this subgroup of patients. We
conclude that the influence on pregnancy outcome after ICSI is related
mostly to maternal and not paternal age.
相似文献
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Dunnick NR; Carson CC; Braun SD; Miller GA; Cohan R; Degesys GE; Illescas FF; Newman GE; Weinerth JL 《Radiology》1985,157(1):51-55
In 224 patients, renal stones were removed from the urinary tract using either direct extraction with a basket or forceps (59 patients), ultrasonic lithotripsy (164 patients), or infusion chemotherapy (one patient). Residual stone fragments were present more frequently in patients treated with ultrasonic lithotripsy (27%) than with direct extraction (5%). Other complications included hemorrhage (eight patients), catheter dislodgement (four patients), large amounts of urine extravasation (three patients), glycine ascites (three patients), infection (two patients), pneumothorax (one patient), and a prolonged ileus (one patient). More complications occurred among the first 50 patients than the last 50 patients, even though more difficult cases, including patients with staghorn calculi, were accepted during the latter period. Although a learning curve exists, complications can be minimized by attempting to treat more favorable cases during the initial experience. 相似文献
68.
Piton A Michaud JL Peng H Aradhya S Gauthier J Mottron L Champagne N Lafrenière RG Hamdan FF;SD team Joober R Fombonne E Marineau C Cossette P Dubé MP Haghighi P Drapeau P Barker PA Carbonetto S Rouleau GA 《Human molecular genetics》2008,17(24):3965-3974
In a systematic sequencing screen of synaptic genes on the X chromosome, we have identified an autistic female without mental retardation (MR) who carries a de novo frameshift Ile367SerfsX6 mutation in Interleukin-1 Receptor Accessory Protein-Like 1 (IL1RAPL1), a gene implicated in calcium-regulated vesicle release and dendrite differentiation. We showed that the function of the resulting truncated IL1RAPL1 protein is severely altered in hippocampal neurons, by measuring its effect on neurite outgrowth activity. We also sequenced the coding region of the close related member IL1RAPL2 and of NCS-1/FREQ, which physically interacts with IL1RAPL1, in a cohort of subjects with autism. The screening failed to identify non-synonymous variant in IL1RAPL2, whereas a rare missense (R102Q) in NCS-1/FREQ was identified in one autistic patient. Furthermore, we identified by comparative genomic hybridization a large intragenic deletion of exons 3-7 of IL1RAPL1 in three brothers with autism and/or MR. This deletion causes a frameshift and the introduction of a premature stop codon, Ala28GlufsX15, at the very beginning of the protein. All together, our results indicate that mutations in IL1RAPL1 cause a spectrum of neurological impairments ranging from MR to high functioning autism. 相似文献
69.
It is now clear that parenteral growth hormone (GH) therapy stimulates growth and increases the adult stature of girls with Turner syndrome. In addition, oestrogens are given to almost all girls with this syndrome because of primary hypogonadism. Oestrogens influence both growth and maturation of the epiphyseal growth plates. Therefore, the form and timing of oestrogen therapy may have an important impact on the outcome of other growth-promoting therapies. To examine the impact of the timing of oestrogen initiation on growth, a randomized trial was conducted in patients with Turner syndrome who were receiving GH. Some patients received oestrogen at 12 years of age, while in others this treatment was not started until 15 years of age. Those girls that received oestrogen later were significantly taller as adults. The single most important factor in determining height gain appeared to be the number of years of GH therapy prior to the initiation of oestrogen treatment. 相似文献
70.