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A prospective, longitudinal two-year study to determine the epidemiology of persistent ( 14 days'duration) diarrhea in rural children of Guatemala was undertaken. Three-hundred and twenty-one children aged 0-35 months were kept under surveillance by twice-a-week home visits. The overall incidence of diarrhea was 0.147 per child-week; the incidence of persistent diarrhea was 0.014 per child-week. The peak of persistent diarrhea was observed in infants below six months of age, with a continuous decline thereafter. This trend in incidence of persistent diarrhea was associated with a higher proportion (16%) of illnesses persisting for more than 13 days in children younger than six months of age as compared to children 30-35 months old (4%). Males had more diarrhea (0.156 per child-week) than females (0.139 per child week). Among children above 18 months of age, the proportion of episodes that lasted for more than 13 days was lower in females than in males. 相似文献
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OL Ivanov AN Lvov AV Michenko J Künzel P Mayser U Gieler 《Journal of the European Academy of Dermatology and Venereology》2009,23(5):499-504
A review of the literature concerning psychogenic purpura is presented. The diagnosis is usually based on typical anamnestic data, clinical presentation (painful inflammatory skin lesions, which progressed to ecchymoses during the next 24 h) and positive diagnostic tests with intracutaneous injections of 80% solution of washed autologous erythrocytes. No pathological findings of blood coagulation parameters are usually detected. Histopathological evaluations of lesional biopsies revealed non-specific changes. Taking into account the high frequency of psychic disorders and stress dependence of skin symptoms, therapy with psychotropic drugs (according to indications) and psychotherapy are pathogenetically grounded methods of treatment in psychogenic purpura, and should be provided together with symptomatic therapy. 相似文献
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A. V. Syrovegin M. L. Kukushkin A. V. Gnezdilov V. K. Reshetnyak A. M. Ovechkin A. M. Ivanov T. S. Li 《Bulletin of experimental biology and medicine》2000,129(3):223-226
Somatosensory evoked potentials and reflectory reaction ofm. thenar to nociceptive electrical stimulation of the index finger before and during its ischemia were studied in healthy volunteers.
The amplitude of early components of the somatosensory evoked potentials N23-P31 and N50-P120 correlated with stimulus intensity,
while the amplitude of N140-P200 did not depend on both stimulus intensity and pain. The nociceptive RIII reflex recorded
fromm. thenar was the most reliable index of pain caused by electrical stimulation of the finger.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 3, pp. 265–268, March, 2000 相似文献
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Hemoglobin M equon beta 41 (C7) phenylalanine leads to tyrosine 总被引:1,自引:0,他引:1
A severe hemolytic crisis was observed in a 34-yr-old female of English- Irish extraction following a viral illness treated with acetaminophen. Heinz bodies and heat instability were present only during a transient hemolytic event. A challenge dose of acetaminophen caused no detectable hematologic abnormality. Structural studies of the hemoglobin during hemolysis and again after complete recovery localized the abnormality to tryptic peptide beta Tp-5, and automated sequencing of I 125-labeled beta chains indicated a replacement of phenylalanine (C7) beta 41 by tyrosine. Substitution of the next residue, phenylalanine (CD1) beta 42 by serine (Hb Hammersmith), has resulted in chronic severe Heinz body hemolytic anemia. The lack of chronic anemia in the present disorder may reflect the different relationships of beta41 and beta 42 and/or the similarities in volume and hydrophobicity of tyrosine and phenylalanine. It is suggested that substitution of tyrosine for phenylalanine in Hb Mequon may disturb the critical environment around the heme group and render it susceptible to oxidative denaturation in the presence of infections and/or drugs. 相似文献
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A Shankar AV Akulwar Y Singh YS Sirohi VRR Chari 《Medical Journal Armed Forces India》2009,65(1):30-32