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991.
Gabriela Neubert da Silva Tatiana Zauer Curi Sara Emília Lima Tolouei Marcella Tapias Passoni Giovanna Beatriz Sari Hey Renata Marino Romano Anderson Joel Martino‐Andrade Paulo Roberto Dalsenter 《Journal of neuroendocrinology》2019,31(12)
Phthalates are found in different plastic materials, such as packaging, toys and medical devices. Some of these compounds are endocrine disruptors, comprising substances that are able to induce multiple hormonal disturbances and downstream developmental effects, including the disruption of androgen‐dependent differentiation of the male reproductive tract and changes in pathways that regulate hormone‐dependent behaviours. In a previous study, metabolites of diisopentyl phthalate (DiPeP), a potent anti‐androgenic phthalate, were found in the urine of Brazilian pregnant women. Therefore, the present study aimed to evaluate the effects of DiPeP exposure during critical developmental periods on behaviours controlled by sex hormones in rats. Pregnant Wistar rats were treated with DiPeP (1, 10 or 100 mg kg day‐1) or canola oil by oral gavage between gestational day 10 and post‐natal day (PND) 21. Male offspring were tested in a behavioural battery, including the elevated plus maze task, play behaviour, partner preference and sexual behaviour. After the behavioural tests, the hypothalamus and pituitary of these animals were removed on PND 60‐65 and PND 145‐160 to quantify gene expression for aromatase, androgen receptor (Ar) and oestrogen receptors α (Esr1) and β (Esr2). Male rats exposed to 1 and 10 mg kg day‐1 DiPeP displayed no preference for the female stimulus rat in the partner preference test and 1 mg kg day‐1 DiPeP rats also showed a significant increase in mount and penetration latencies when mated with receptive females. A decrease in pituitary Esr1 expression was observed in all DiPeP treated groups regardless of age. A reduction in hypothalamic Esr1 expression in rats exposed to 10 mg kg day‐1 DiPeP was also observed. No significant changes were found with respect to Ar, Esr2 and aromatase expression in the hypothalamus. These results suggest that DiPeP exposure during critical windows of development in rats may induce changes in behaviours related to mating and the sexual motivation of males. 相似文献
992.
Miriam Duci Anna Chiara Frigo Silvia Visentin Giovanna Verlato Piergiorgio Gamba Francesco Fascetti-Leon 《Journal of pediatric surgery》2019,54(10):2099-2102
Background/purposeAntenatal factors play an important role in NEC. This study aimed to identify antenatal risk factors associated with the development of NEC, the role of the placental alterations, and the presence of prenatal signs predisposing to a severe NEC.Materials/methodsData of NEC patients including antenatal findings [preeclampsia, diabetes, cholestasis, abnormal antenatal umbilical artery flow (AAUF), clinical chorioamnionitis (CC), and histology of placentas] were compared to unaffected cases between 2002 and 2016 in a single center. Unaffected infants were matched for gestational age. Newborns with cardiovascular diseases were excluded. Bivariate and multivariate analyses were performed.ResultsWe identified 136 cases and 134 controls. The group of mothers of NEC-neonates had a higher prevalence of preeclampsia, CC, and AAUF. Histology of Placentas from 123/136 cases and 126/133 unaffected newborns was available. Chorioamnionitis was significantly more present in NEC cases vs controls. There weren't differences in vascular anomalies and necrotic alterations. Multivariate analysis identified AAUF, CC and histological chorioamnionitis (HC) as predictors of NEC. Bivariate tests show that preeclampsia and HC occurred more often in severe cases of NEC.ConclusionThis study suggests that AAUF, CC, and HC can independently predict the risk of NEC. Preeclampsia and HC seem associated to more severe cases.Level of evidenceIIIA. 相似文献
993.
Agnes Schwieger-Briel Ignacia Fuentes Daniele Castiglia Antonio Barbato Matthias Greutmann Juna Leppert Sabine Duchatelet Alain Hovnanian Sofia Burattini M. Joao Yubero Rodrigo Ibañez-Arenas Boris Rebolledo-Jaramillo Christoph Gräni Hagen Ott Martin Theiler Lisa Weibel Amy S. Paller Giovanna Zambruno Cristina Has 《The Journal of investigative dermatology》2019,139(1):244-249
994.
995.
HER2 Positivity Predicts Unresponsiveness to EGFR-Targeted Treatment in Metastatic Colorectal Cancer
Andrea Sartore-Bianchi Alessio Amatu Luca Porcu Silvia Ghezzi Sara Lonardi Francesco Leone Francesca Bergamo Elisabetta Fenocchio Erika Martinelli Beatrice Borelli Federica Tosi Patrizia Racca Emanuele Valtorta Emanuela Bonoldi Cosimo Martino Caterina Vaghi Giovanna Marrapese Fortunato Ciardiello Vittorina Zagonel Alberto Bardelli Livio Trusolino Valter Torri Silvia Marsoni Salvatore Siena 《The oncologist》2019,24(10):1395-1402
996.
Lievin Matos Reboucas Conceicao Souza Campos Giovanna Melicio D'Amico Alysson Bastos Lustosa Jose Humberto Fregnani 《The breast journal》2019,25(5):953-957
Hypofractionated radiotherapy (HF) in 15 or 16 daily fractions is well established as an alternative in early breast cancer after breast‐conserving surgery. Evidences for a whole‐breast treatment even shorter, in 5‐10 fractions, are still scarce. Women 50 years or older, with early breast tumor (pT1‐2pN0), after breast‐conserving surgery were eligible to enter in this phase II trial and received whole breast once‐weekly hypofractionated radiotherapy (wHF‐RT) to a total dose of 30 Gy, in 5 fractions of 6 Gy. During treatment and in post‐treatment follow‐up the toxicity was assessed and graduated according to the “Common Terminology Criteria for Adverse Events” (CTCAE), v3.0. Breast pictures for esthetic comparison were taken in 5 timepoints and 2 breast surgeons independently graduated the cosmetics changes. The trial was registered with ClinicalTrials.gov, number NCT01965483. From October 2013 to November 2015, 44 patients were enrolled in the trial and treated according to the protocol of wHF‐RT. The median age was 70.5 years (51‐88 years), and the median follow‐up was 22 months (9‐33 months). Skin erythema was the most common acute adverse event. At the end of radiation, 30 patients (68.2%) had any grade of radiation dermatitis. Concerning cosmetic appearance, there was no significant difference between pretreatment and 1 year assessments. The 2‐year overall survival and disease‐free survival were, respectively 96.8% and 97.7%. There was only one distant recurrence and no local or regional recurrence. Once‐weekly hypofractionated radiotherapy is a feasible and well tolerated alternative for early breast cancer adjuvant management with acceptable acute toxicity and esthetic outcomes. 相似文献
997.
998.
Gabriella Santangelo Giovanna Lagravinese Valeria Battini Carlo Chiorri Mattia Siciliano Giovanni Abbruzzese Carmine Vitale Paolo Barone 《Neurological sciences》2017,38(5):845-853
The Parkinson’s Disease-Cognitive Rating Scale (PD-CRS) is a cognitive screening battery that includes subtests to assess cortical and subcortical functions. It is a valid screening tool for mild cognitive impairment (MCI) in Parkinson’s disease (PD) and is recommended for diagnosing PD-MCI-Level I. Until now, no study has provided population-based norms for the Italian population. The aim of the present study was to collect normative values in a sample of Italian healthy subjects. Two hundred and sixty-eight (125 men) participants of different ages (age range 30–79 years) and educational levels (from primary school to university) underwent the PD-CRS. Regression-based norming was used to explore the influence of demographic variables (age, education level, and gender) on PD-CRS total score, frontal-subcortical and instrumental-cortical sub-scores, and score achieved on each task of the PD-CRS. Multiple linear regression analysis revealed that age and education significantly predicted the total score, the two sub-scores and the score on each task of the PD-CRS. No significant effect of gender was found. From the derived linear equations, a correction grid for raw scores was developed. Inferential cut-off scores, estimated using a non-parametric technique, were 71.25 for PD-CRS total score and 46.25 and 20.17 for frontal-subcortical and instrumental-cortical sub-score, respectively. Since the use of adjusted scores is more informative when they are standardized, we have converted adjusted scores into equivalent scores. The present study provides normative data for the PD-CRS, being useful and recommended by Movement Disorders Society task force to identify PD-MCI-Level I, at several stages of the disease. 相似文献
999.
Degli Esposti Luca Piccinni Carlo Sangiorgi Diego Perrone Valentina Aledda Lucia Marrosu Maria Giovanna Lombardo Fabio 《Neurological sciences》2017,38(4):589-594
Neurological Sciences - This study was aimed to describe changes of Disease-Modifying Treatments (DMT) in an Italian cohort of patients with multiple sclerosis (MS) and to identify predictors of... 相似文献
1000.
Incidence,Prevalence, and Survival of Biopsy‐Proven Giant Cell Arteritis in Northern Italy During a 26‐Year Period
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