全文获取类型
收费全文 | 3878篇 |
免费 | 407篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 86篇 |
儿科学 | 110篇 |
妇产科学 | 61篇 |
基础医学 | 466篇 |
口腔科学 | 61篇 |
临床医学 | 462篇 |
内科学 | 779篇 |
皮肤病学 | 61篇 |
神经病学 | 200篇 |
特种医学 | 331篇 |
外科学 | 558篇 |
综合类 | 89篇 |
预防医学 | 456篇 |
眼科学 | 52篇 |
药学 | 323篇 |
中国医学 | 3篇 |
肿瘤学 | 267篇 |
出版年
2021年 | 53篇 |
2020年 | 39篇 |
2019年 | 67篇 |
2018年 | 70篇 |
2017年 | 51篇 |
2016年 | 46篇 |
2015年 | 70篇 |
2014年 | 95篇 |
2013年 | 108篇 |
2012年 | 145篇 |
2011年 | 160篇 |
2010年 | 105篇 |
2009年 | 123篇 |
2008年 | 119篇 |
2007年 | 174篇 |
2006年 | 128篇 |
2005年 | 136篇 |
2004年 | 141篇 |
2003年 | 130篇 |
2002年 | 139篇 |
2001年 | 115篇 |
2000年 | 159篇 |
1999年 | 107篇 |
1998年 | 103篇 |
1997年 | 102篇 |
1996年 | 82篇 |
1995年 | 79篇 |
1994年 | 60篇 |
1993年 | 73篇 |
1992年 | 86篇 |
1991年 | 75篇 |
1990年 | 68篇 |
1989年 | 93篇 |
1988年 | 73篇 |
1987年 | 80篇 |
1986年 | 87篇 |
1985年 | 87篇 |
1984年 | 50篇 |
1983年 | 39篇 |
1982年 | 30篇 |
1979年 | 42篇 |
1978年 | 30篇 |
1977年 | 40篇 |
1976年 | 29篇 |
1975年 | 36篇 |
1974年 | 30篇 |
1973年 | 39篇 |
1972年 | 34篇 |
1969年 | 30篇 |
1967年 | 28篇 |
排序方式: 共有4365条查询结果,搜索用时 156 毫秒
91.
92.
Understanding the alcohol harm paradox: an analysis of sex‐ and condition‐specific hospital admissions by socio‐economic group for alcohol‐associated conditions in England
下载免费PDF全文
![点击此处可从《Addiction (Abingdon, England)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
93.
Romina J. Fernandez-Brando Nao Yamaguchi Amin Tahoun Sean P. McAteer Trudi Gillespie Dai Wang Sally A. Argyle Marina S. Palermo David L. Gally 《Antimicrobial agents and chemotherapy》2016,60(1):459-470
A subset of Gram-negative bacterial pathogens uses a type III secretion system (T3SS) to open up a conduit into eukaryotic cells in order to inject effector proteins. These modulate pathways to enhance bacterial colonization. In this study, we screened established bioactive compounds for any that could repress T3SS expression in enterohemorrhagic Escherichia coli (EHEC) O157. The ketolides telithromycin and, subsequently, solithromycin both demonstrated repressive effects on expression of the bacterial T3SS at sub-MICs, leading to significant reductions in bacterial binding and actin-rich pedestal formation on epithelial cells. Preincubation of epithelial cells with solithromycin resulted in significantly less attachment of E. coli O157. Moreover, bacteria expressing the T3SS were more susceptible to solithromycin, and there was significant preferential killing of E. coli O157 bacteria when they were added to epithelial cells that had been preexposed to the ketolide. This killing was dependent on expression of the T3SS. Taken together, this research indicates that the ketolide that has accumulated in epithelial cells may traffic back into the bacteria via the T3SS. Considering that neither ketolide induces the SOS response, nontoxic members of this class of antibiotics, such as solithromycin, should be considered for future testing and trials evaluating their use for treatment of EHEC infections. These antibiotics may also have broader significance for treating infections caused by other pathogenic bacteria, including intracellular bacteria, that express a T3SS. 相似文献
94.
Barry R. Gillespie John F. Barnes 《Cranio : the journal of craniomandibular practice》2013,31(4):342-349
The normal physiologic tension of the TMJ muscles, fascia, ligaments, and associated structures is critical for the health of children. Pathologic strain patterns in the soft tissues can be a primary cause of headaches, neckaches, throat infections, ear infections, sinus congestion, and asthma. This article presents effective diagnostic and treatment modalities from both dental and physical therapy viewpoints to relieve and restore normal physiology to the TMJ muscles, fascia, ligaments, and associated structures. As structural balance is restored, a nutritional component of therapy is strongly recommended for the child's optimum health. 相似文献
95.
96.
97.
98.
Testing associations between cannabis use and subcortical volumes in two large population‐based samples
下载免费PDF全文
![点击此处可从《Addiction (Abingdon, England)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Nathan A. Gillespie Michael C. Neale Timothy C. Bates Lisa T. Eyler Christine Fennema‐Notestine Jasmin Vassileva Michael J. Lyons Elizabeth C. Prom‐Wormley Katie L. McMahon Paul M. Thompson Greig de Zubicaray Ian B. Hickie John J. McGrath Lachlan T. Strike Miguel E. Rentería Matthew S. Panizzon Nicholas G. Martin Carol E. Franz Margaret J. Wright 《Addiction (Abingdon, England)》2018,113(9):1661-1672
99.
100.