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Adri Ramírez Mena Ndeye Fatou Ngom Judicaël Tine Kine Ndiaye Louise Fortes Ousseynou Ndiaye Maguette Fall Assietou Gaye Daye Ka Moussa Seydi Gilles Wandeler 《Viruses》2022,14(8)
Hepatitis B virus (HBV) infection is the first cause of liver cirrhosis and cancer in West Africa. Although the exposure to additional environmental and infectious risk factors may lead to the faster progression of liver disease, few large-scale studies have evaluated the determinants of HBV-related liver fibrosis in the region. We used transient elastography to evaluate the prevalence of liver fibrosis and assessed the association between HBV markers and significant liver fibrosis in a cohort of people living with HBV in Dakar, Senegal. The prevalence of significant liver fibrosis was 12.5% (95% confidence interval [CI] 9.6%–15.9%) among 471 people with HBV mono-infection (pwHBV) and 6.4% (95% CI 2.6%–12.7%) in 110 people with HIV/HBV co-infection (pwHIV/HBV) on tenofovir-containing antiretroviral therapy (p = 0.07). An HBV viral load > 2000 IU/mL was found in 133 (28.3%) pwHBV and 5 (4.7%) pwHIV/HBV, and was associated with significant liver fibrosis (adjusted odds ratio (aOR) 1.95, 95% CI 1.04–3.66). Male participants (aOR 4.32, 95% CI 2.01–8.96) and those with elevated ALT (aOR 4.32, 95% CI 2.01–8.96) were especially at risk of having significant liver fibrosis. Our study shows that people with an HBV viral load above 2000 IU/mL have a two-fold increase in the risk of liver fibrosis and may have to be considered for antiviral therapy, independent of other disease parameters. 相似文献
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Dimitri Gambachidze Chloë Lefvre Emmanuel Chartier‐Kastler Marie‐Aime Perrouin Verbe Jacques Kerdraon Guy Egon Alexia Even Pierre Denys Evelyne Castel‐Lacanal Xavier Gam Alain Ruffion Juliette Hascoet Benoit Peyronnet Haude Chaussard Kvin Lo Verde Gilles Karsenty Vronique Ph 《Neurourology and urodynamics》2019,38(6):1713-1720
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In this research, bibliotherapy combined with a positive reinforcement procedure was applied to the treatment of premature ejaculation. The results indicate that it is possible to obtain significant improvement in ejaculatory latency by using only a self-administered treatment. Moreover, this study indicates that this improvement is identical to the one obtained when therapists conduct the treatment. Although more subjects treated by bibliotherapy quit the treatment, bibliotherapy was very useful 相似文献
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Isabel Meister Katrin Ingram-Sieber Noemi Cowan Matthew Todd Murray N. Robertson Claudia Meli Malay Patra Gilles Gasser Jennifer Keiser 《Antimicrobial agents and chemotherapy》2014,58(9):5466-5472
A racemic mixture of R and S enantiomers of praziquantel (PZQ) is currently the treatment of choice for schistosomiasis. Though the S enantiomer and the metabolites are presumed to contribute only a little to the activity of the drug, in-depth side-by-side studies are lacking. The aim of this study was to investigate the in vitro activities of PZQ and its main metabolites, namely, R- and S-cis- and R- and S-trans-4′-hydroxypraziquantel, against adult worms and newly transformed schistosomula (NTS). Additionally, we explored the in vivo activity and hepatic shift (i.e., the migration of the worms to the liver) produced by each PZQ enantiomer in mice. Fifty percent inhibitory concentrations of R-PZQ, S-PZQ, and R-trans- and R-cis-4′-hydroxypraziquantel of 0.02, 5.85, 4.08, and 2.42 μg/ml, respectively, for adult S. mansoni were determined in vitro. S-trans- and S-cis-4′-hydroxypraziquantel were not active at 100 μg/ml. These results are consistent with microcalorimetry data and studies with NTS. In vivo, single 400-mg/kg oral doses of R-PZQ and S-PZQ achieved worm burden reductions of 100 and 19%, respectively. Moreover, worms treated in vivo with S-PZQ displayed an only transient hepatic shift and returned to the mesenteric veins within 24 h. Our data confirm that R-PZQ is the main effector molecule, while S-PZQ and the metabolites do not play a significant role in the antischistosomal properties of PZQ. 相似文献