全文获取类型
收费全文 | 1133篇 |
免费 | 44篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 36篇 |
妇产科学 | 43篇 |
基础医学 | 62篇 |
口腔科学 | 37篇 |
临床医学 | 475篇 |
内科学 | 153篇 |
皮肤病学 | 6篇 |
神经病学 | 47篇 |
特种医学 | 116篇 |
外科学 | 54篇 |
综合类 | 26篇 |
预防医学 | 45篇 |
眼科学 | 7篇 |
药学 | 50篇 |
肿瘤学 | 55篇 |
出版年
2023年 | 7篇 |
2021年 | 3篇 |
2020年 | 5篇 |
2019年 | 8篇 |
2018年 | 15篇 |
2017年 | 4篇 |
2016年 | 8篇 |
2015年 | 18篇 |
2014年 | 18篇 |
2013年 | 40篇 |
2012年 | 20篇 |
2011年 | 10篇 |
2010年 | 31篇 |
2009年 | 37篇 |
2008年 | 32篇 |
2007年 | 36篇 |
2006年 | 29篇 |
2005年 | 27篇 |
2004年 | 38篇 |
2003年 | 25篇 |
2002年 | 29篇 |
2001年 | 38篇 |
2000年 | 26篇 |
1999年 | 38篇 |
1998年 | 92篇 |
1997年 | 86篇 |
1996年 | 80篇 |
1995年 | 67篇 |
1994年 | 50篇 |
1993年 | 56篇 |
1992年 | 21篇 |
1991年 | 26篇 |
1990年 | 28篇 |
1989年 | 23篇 |
1988年 | 35篇 |
1987年 | 11篇 |
1986年 | 15篇 |
1985年 | 12篇 |
1984年 | 14篇 |
1983年 | 7篇 |
1982年 | 10篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1971年 | 3篇 |
1962年 | 1篇 |
1958年 | 2篇 |
排序方式: 共有1214条查询结果,搜索用时 31 毫秒
951.
Kenneth CS Fong FRCOphth Nigel Kirkpatrick FRCOphth Quresh Mohamed FRCOphth Robert L Johnston FRCOphth 《Clinical & experimental ophthalmology》2008,36(8):748-755
Purpose: To evaluate a variable frequency regimen with intravitreal bevacizumab for treatment of neovascular age‐related macular degeneration (AMD) in eyes that have not received any previous treatment. Methods: Retrospective review of patients with neovascular AMD who were treated with three consecutive monthly intravitreal injections of bevacizumab (1.25 mg) and retreated based on the PrONTO study criteria. Outcome measures included visual acuity (VA) and central retinal thickness. Subgroup analysis was conducted to identify pretreatment characteristics that could determine visual outcome with treatment. Results: A total of 109 eyes of 109 patients were treated. The mean age was 82 years, and the mean follow‐up period was 9.4 months (range 6–12 months). At baseline, the mean VA was 45.6 letters (6/37.5) and mean central retinal thickness 343 µm. This improved to 51 letters (6/30) (P < 0.001)) and 231 µm (P < 0.001) at 6 months. At 6 months, VA was improved by at least five letters in 50%, remained stable in 30% and worsened by at least five letters in 20% of patients. Patients with large intraretinal cysts on optical coherence tomography before treatment had an increased risk of worse vision (odds ratio 10.5, 95% confidence interval 1.69–64.99; P = 0.018). Conclusions: The majority of patients had improvement or stability of VA regardless of the angiographic type of choroidal neovascularization. Intravitreal bevacizumab with this tailored regimen is beneficial in the treatment of neovascular AMD in the short term. The presence of large intraretinal cysts on optical coherence tomography is a poor prognostic factor for visual improvement with this treatment. 相似文献
952.
Athanasios Protopapas George Giannoulis Ioannis Chatzipapas Stavros Athanasiou Themistoklis Grigoriadis Nikolaos Kathopoulis Dimitrios-Efthymios Vlachos Dimitrios Zaharakis Dimitrios Loutradis 《Journal of minimally invasive gynecology》2019,26(3):441-449
Study Objective
Τo investigate whether the use of vasopressin played an important role in the safe expansion of the indications of laparoscopic myomectomy in our practice.Design
A retrospective comparison of prospectively collected data (Canadian Task Force classification II2).Setting
A gynecologic endoscopy unit in a tertiary university hospital.Patients
One hundred fifty patients undergoing laparoscopic myomectomy; 50 were treated without the use of any vasoconstrictive agent (group 1), and 100 were treated with intraoperative intramyometrial injection of dilute vasopressin (20 IU/100 mL normal saline) (group 2).Interventions
Laparoscopic myomectomy.Measurements and Main Results
We compared the 2 groups in terms of size, number, and type of myomas; estimated blood loss (EBL); procedure length; transfusion rates; laparoconversion rates; and rates of complications. Two cases in group 1 (4%) were laparoconverted versus none (0%) in group 2. Overall, the mean EBL was 321.8 ± 246.0 mL in group 1 compared with 147.8 ± 171.8 mL in group 2, respectively (p <.001). Additionally, EBL was significantly lower in the vasopressin group in all of the study's subgroups of patients stratified according to the size and number of myomas. Procedure length did not differ significantly between the 2 groups (130.8 ± 49.5 vs 115.6 ± 49.4 minutes, p?=?.078). The risk factors for prolongation of the procedure included size and number of myomas independently of vasopressin. The rates of hypercapnea and subcutaneous emphysema were higher in group 1. The risk factors for hypercapnea and subcutaneous emphysema included the size and intramural position of the largest myoma. Vasopressin was not associated with serious cardiovascular adverse events.Conclusions
Vasopressin is effective in reducing blood loss during laparoscopic myomectomy. Although experienced surgeons may achieve comparable operation times without vasopressin, even in the most challenging cases, blood loss may still be considerable. The occurrence of hypercapnea is higher in untreated cases and may contribute to laparoconversion. 相似文献953.
Primary hyperparathyroidism in childhood and adolescence 总被引:2,自引:0,他引:2
CS CRONIN TS REEVE B ROBINSON P CLIFTON-BLIGH A GUINEA L DELBRIDGE 《Journal of paediatrics and child health》1996,32(5):397-399
Objective : The aim of this study was to determine the nature of the presentation and pathology of primary hyperparathyroidism in children and adolescents and to compare these findings with adults.
Methodology : Data were obtained from the Thyroid Surgery Database at Royal North Shore Hospital on all children and adolescents undergoing parathyroid surgery. These results were then compared to data obtained from the last 100 consecutive adult parathyroidectomies.
Results : A total of eight younger patients underwent parathyroidectomy including three children (0–12 years) and five adolescents (13–18 years). A common presentation in the younger age group was hypercalcaemic crisis (50%) with a serum calcium >3.5 mmol/L and clinical signs of calcium intoxication. This compared to the adult age group where only 8% presented with crisis ( P <0.05). Eighty-eight per cent of the younger patients complained of abdominal symptoms compared to only 1% of adults. Seven of eight young patients had sporadic hyperparathyroidism.
Conclusions : Primary hyperparathyroidism, although uncommon in the younger age group, is still most commonly associated with sporadic tumours. Familial syndromes do not constitute a large percentage of patients. Younger patients are more prone to present late with abdominal symptoms, toxicity and hypercalcaemic crisis, presumably due to delayed diagnosis of an uncommon condition in this age group. 相似文献
Methodology : Data were obtained from the Thyroid Surgery Database at Royal North Shore Hospital on all children and adolescents undergoing parathyroid surgery. These results were then compared to data obtained from the last 100 consecutive adult parathyroidectomies.
Results : A total of eight younger patients underwent parathyroidectomy including three children (0–12 years) and five adolescents (13–18 years). A common presentation in the younger age group was hypercalcaemic crisis (50%) with a serum calcium >3.5 mmol/L and clinical signs of calcium intoxication. This compared to the adult age group where only 8% presented with crisis ( P <0.05). Eighty-eight per cent of the younger patients complained of abdominal symptoms compared to only 1% of adults. Seven of eight young patients had sporadic hyperparathyroidism.
Conclusions : Primary hyperparathyroidism, although uncommon in the younger age group, is still most commonly associated with sporadic tumours. Familial syndromes do not constitute a large percentage of patients. Younger patients are more prone to present late with abdominal symptoms, toxicity and hypercalcaemic crisis, presumably due to delayed diagnosis of an uncommon condition in this age group. 相似文献
954.
Konstantinos Natsis Maria Piagkou Ioannis Chryssanthou Georgios P. Skandalakis Georgios Tsakotos Giannoulis Piagkos Constantinus Politis 《Journal of cranio-maxillo-facial surgery》2019,47(1):185-189
Background
The orbital floor (OrF) and infraorbital rim (IOR) repair in cases of complete destruction is challenging mainly due to the fact that the defect length cannot be measured. The aim of the current study is to develop a method of calculating the Orf length by using the gender and the lengths of the medial, superior and lateral orbital walls (OrW) of the same orbit.Material and methods
Ninety-seven (59 male and 38 female) European adult dry skulls were classified according to age: 20–39, 40–59 and 60 years and above. The length of each OrW was measured by using the direct distance between the optic foramen and a landmark in each orbital rim.Results
A side asymmetry was detected for the lengths of the inferior, superior and medial OrW. Although a gender dimorphism was detected, no correlation with the age was found. Using the Stepwise multiple regression analysis two formulas were developed, one for the right and one for the left OrF with coefficient of determination R2 0.43 and 0.57, respectively.Conclusions
The proposed formulas represent a simple, applicable and individualized method to calculate the OrF linear length in cases of complete destruction of the IOR and OrF, with accuracy and without the use of expertise material. Such data may improve the surgery planning of orbital floor fractures and complex orbital reconstructions. 相似文献955.
Arylamine N-acetyltransferase (NAT) research has been influenced in recent years by the rapid progress in genomics, proteomics, structural genomics and other cutting-edge disciplines. To keep up with these advancements, the NAT scientific community has fostered collaboration and exchange of know-how between its members. As a specialized event bringing together experts from many different laboratories, the triennial International NAT Workshop has been instrumental in maintaining this culture over the past ten years. The 2007 Workshop took place in Alexandroupolis, Greece, and covered ongoing research on the structure and enzymatic function of human NATs, the prokaryotic and eukaryotic models for NAT, the mechanisms of NAT gene regulation and expression, the frequencies and effects of polymorphisms in the human NAT genes, and the involvement of NATs in multifactorial diseases, including cancer, allergic conditions, endometriosis and endemic nephropathies. Gene nomenclature issues were also addressed and the participants discussed current trends in the field. 相似文献
956.
957.
958.
Randomized controlled trial evaluating a novel community eye care programme for elderly individuals with visual impairment
下载免费PDF全文
![点击此处可从《Clinical & experimental ophthalmology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
959.
960.