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61.
Asif Padiyath M.D. Paul Gribben B.S. Joseph R. Abraham B.S. Ling Li M.D. Ph.D. Sheela Rangamani M.D. Andreas Schuster M.D. David A. Danford M.D. Gianni Pedrizzetti Ph.D. Shelby Kutty M.D. 《Echocardiography (Mount Kisco, N.Y.)》2013,30(2):203-210
We investigated intermodality agreements of strains from two‐dimensional echocardiography (2DE) and cardiac magnetic resonance (CMR) feature tracking (FT) in the assessment of right (RV) and left ventricular (LV) mechanics in tetralogy of Fallot (TOF). Patients were prospectively studied with 2DE and CMR performed contiguously. LV and RV strains were computed separately using 2DE and CMR‐FT. Segmental and global longitudinal strains (GLS) for the LV and RV were measured from four‐chamber views; LV radial (global radial strain [GRS]) and circumferential strains (GCS) measured from short‐axis views. Intermodality and interobserver agreements were examined. In 40 patients (20 TOF, mean age 23 years and 20 adult controls), LV, GCS showed narrowest intermodality limits of agreement (mean percentage error 9.5%), followed by GLS (16.4%). RV GLS had mean intermodality difference of 25.7%. GLS and GCS had acceptable interobserver agreement for the LV and RV with both 2DE and CMR‐FT, whereas GRS had high interobserver and intermodality variability. In conclusion, myocardial strains for the RV and LV derived using currently available 2DE and CMR‐FT software are subject to considerable intermodality variability. For both modalities, LV GCS, LV GLS, and RV GLS are reproducible enough to warrant further investigation of incremental clinical merit. 相似文献
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Prognostic value of chromogranin A in chronic heart failure: data from the GISSI‐Heart Failure trial
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Domenico G. Della Rocca MD Michele Magnocavallo MD Veronica N. Natale MPH Carola Gianni MD PhD Sanghamitra Mohanty MD Chintan Trivedi MD MPH Carlo Lavalle MD Giovanni B. Forleo MD PhD Nicola Tarantino MD Jorge Romero MD Xiadong Zhang MD Mohamed Bassiouny MD Amin Al-Ahmad MD David J. Burkhardt MD Joseph G. Gallinghouse MD Javier E. Sanchez MD Rodney P. Horton MD Luigi Di Biase MD PhD Andrea Natale MD 《Journal of cardiovascular electrophysiology》2021,32(9):2441-2450
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Red-cell GSH regeneration and glutathione reductase activity in G6PD variants in the Ferrara area 总被引:2,自引:0,他引:2
Barbara B. Anderson Gianni Carandina Marco Lucci Gillian M. Perry† Calogero Vullo 《British journal of haematology》1987,67(4):459-466
Summary. Red-cell studies were carried out on three groups of G6PD-deficient subjects with different G6PD variants from the Ferrara area of Northern Italy. Red-cell GSH and activities of G6PD, glutathione reductase (GR), glutathione peroxidase (GPx) and superoxide dismutase (SOD) were measured. A method was developed to measure red-cell GSH regeneration after oxidation of endogenous GSH in whole blood by diamide and only this clearly distinguished the variants from each other and from normal. Regeneration by 1 h was lowest in the Mediterranean variant, 0–10.2% in contrast to 93–98% in normal. A predisposition to a haemolytic crisis after ingestion of fava beans was not clearcut, but subjects appeared to be at risk if GSH regeneration at 1 h was less than 30% of the endogenous level, and red-cell FAD+ was very high indicated by high in vitro GR activity and inhibition by added FAD+ .
It is suggested that the most informative tests in G6PD deficiency are measurements of GSH regeneration in intact red cells plus GR activity and/or red-cell flavin compounds. 相似文献
It is suggested that the most informative tests in G6PD deficiency are measurements of GSH regeneration in intact red cells plus GR activity and/or red-cell flavin compounds. 相似文献
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