全文获取类型
收费全文 | 521篇 |
免费 | 27篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 36篇 |
妇产科学 | 2篇 |
基础医学 | 43篇 |
口腔科学 | 18篇 |
临床医学 | 34篇 |
内科学 | 132篇 |
皮肤病学 | 8篇 |
神经病学 | 9篇 |
特种医学 | 79篇 |
外科学 | 63篇 |
综合类 | 62篇 |
预防医学 | 20篇 |
眼科学 | 8篇 |
药学 | 20篇 |
肿瘤学 | 20篇 |
出版年
2024年 | 1篇 |
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 6篇 |
2020年 | 5篇 |
2019年 | 2篇 |
2018年 | 6篇 |
2017年 | 4篇 |
2016年 | 9篇 |
2015年 | 16篇 |
2014年 | 11篇 |
2013年 | 16篇 |
2012年 | 8篇 |
2011年 | 12篇 |
2010年 | 19篇 |
2009年 | 32篇 |
2008年 | 11篇 |
2007年 | 20篇 |
2006年 | 31篇 |
2005年 | 8篇 |
2004年 | 9篇 |
2003年 | 3篇 |
2002年 | 7篇 |
2001年 | 10篇 |
2000年 | 7篇 |
1999年 | 13篇 |
1998年 | 42篇 |
1997年 | 31篇 |
1996年 | 40篇 |
1995年 | 17篇 |
1994年 | 18篇 |
1993年 | 22篇 |
1992年 | 4篇 |
1991年 | 8篇 |
1990年 | 2篇 |
1989年 | 9篇 |
1988年 | 24篇 |
1987年 | 9篇 |
1986年 | 8篇 |
1985年 | 17篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1977年 | 3篇 |
1976年 | 5篇 |
1975年 | 3篇 |
排序方式: 共有555条查询结果,搜索用时 0 毫秒
81.
Kirsi M Talala Taina M Huurre Tiina KM Laatikainen Tuija P Martelin Aini I Ostamo Ritva S Prättälä 《BMC public health》2011,11(1):138
Background
Psychological factors associated with low social status have been proposed as one possible explanation for the socio-economic gradient in health. The aim of this study is to explore whether different indicators of psychological distress contribute to socio-economic differences in cause-specific mortality. 相似文献82.
83.
Clustering of mutations in the biotin-binding region of holocarboxylase synthetase in biotin-responsive multiple carboxylase deficiency 总被引:4,自引:2,他引:2
Dupuis L; Leon-Del-Rio A; Leclerc D; Campeau E; Sweetman L; Saudubray JM; Herman G; Gibson KM; Gravel RA 《Human molecular genetics》1996,5(7):1011-1016
Holocarboxylase synthetase (HCS) catalyses the biotinylation of the four
biotin-dependent carboxylases found in humans. A deficiency in HCS results
in biotin-responsive multiple carboxylase deficiency (MCD). We have
identified six different point mutations in the HCS gene in nine patients
with MCD. Two of the mutations are frequent among the MCD patients
analyzed. Four of the mutations cluster in the putative biotin- binding
domain as deduced from the corresponding Escherichia coli enzyme and
consistent with an explanation for biotin-responsiveness based on altered
affinity for biotin. The two others may define an additional domain
involved in biotin-binding or biotin-mediated stabilization of the protein.
相似文献
84.
85.
86.
87.
88.
89.
Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin) 总被引:13,自引:6,他引:7
Saelman EU; Nieuwenhuis HK; Hese KM; de Groot PG; Heijnen HF; Sage EH; Williams S; McKeown L; Gralnick HR; Sixma JJ 《Blood》1994,83(5):1244-1250
Platelet adhesion to fibrillar collagens (types I, II, III, and V) and nonfibrillar collagens (types IV, VI, VII, and VIII) was investigated in the presence of physiologic concentrations of divalent cations under conditions of stasis and flow. Under static conditions, platelet adhesion was observed to collagen types I through VII but not to type VIII. Under flow conditions, platelet adhesion to collagen types I, II, III, and IV was almost independent of shear rates above 300/s. Collagen type V was nonadhesive. Platelet adhesion to collagen type VI was shear rate-dependent and optimal at a rate of 300/s. Collagen types VII and VIII showed minor reactivity and supported platelet adhesion only between shear rates 100 to 1,000/s. Monoclonal antibody (MoAb) 176D7, directed against platelet membrane glycoprotein Ia (GPIa; very late antigen [VLA]-alpha 2 subunit), completely inhibited platelet adhesion to all collagens tested, under conditions of both stasis and flow. Platelet adhesion to collagen type III at shear rate 1,600/s was only inhibited for 85%. The concentration of antibody required for complete inhibition of platelet adhesion was dependent on the shear rate and the reactivity of the collagen. An MoAb directed against GPIIa (VLA-beta subunit) partially inhibited platelet adhesion to collagen. These results show that GPIa-IIa is a major and universal platelet receptor for eight unique types of collagen. 相似文献
90.
Pseudoaneurysms complicating organ transplantation: roles of CT, duplex sonography, and angiography 总被引:2,自引:0,他引:2
Tobben PJ; Zajko AB; Sumkin JH; Bowen A; Fuhrman CR; Skolnick ML; Bron KM; Esquivel CO; Starzl TE 《Radiology》1988,169(1):65-70
In a retrospective study of proved pseudoaneurysms (PAs) in 15 patients with transplanted organs (11 liver, three kidney, one pancreas), the results of computed tomography (CT), duplex sonography, and angiography were reviewed. Of the 15 cases of PA, eight occurred at the arterial anastomosis and seven were nonanastomotic. Three of the eight anastomotic PAs were caused by infection. Of the seven nonanastomotic PAs, four were caused by percutaneous biopsy, two were caused by infection, and one was of undetermined cause. In nine (60%) of the 15 patients the PAs were incidentally detected at imaging studies performed for other reasons. Diagnosis requires a high degree of suspicion. CT was performed in nine cases and duplex sonography in ten. The diagnosis of PA was made with CT in six (67%) patients and with duplex sonography in five (50%). CT and duplex sonography could not enable diagnosis when the PA was small, when the arterial anastomosis was not included in the field of study, or when enhancement with intravenously administered contract material was suboptimal. Angiography depicted the PAs in all 15 patients. In three liver transplant recipients with gastrointestinal tract bleeding, the causative PAs were detected only with angiography. 相似文献