苍耳子不良反应研究进展

苍耳子是传统的鼻科要药,具有散风除湿、通鼻窍的功效,被认为无毒或有小毒。然而近年来不断有正常剂量或是过量服用苍耳子出现肾脏、肝脏、心脏损伤或是腹痛、恶心、呕吐等不良反应报道,其中肾脏和肝脏损伤引起了大量的关注和研究。从临床报道和动物实验两方面对服用苍耳子出现的以肾脏损伤为主的不良反应进行综述,总结了引起多器官损伤的毒性物质、毒性机制、量毒关系、炮制方法对毒性的影响等,为进一步研究苍耳子安全用药提供依据。     

Simultaneous determination of lidocaine hydrochloride, hydrocortisone and nystatin in a pharmaceutical preparation by RP-LC

A liquid chromatographic (LC) method was developed to analyze a formulation (mouthwash) containing lidocaine hydrochloride, hydrocortisone and nystatin. A single LC method with UV detection was developed. A Waters Symmetry C18 HPLC column (150 mm ×  4.6 mm, 5 μm) was used as stationary phase and the assay was performed with gradient elution using mobile phases containing methanol - 0.1 M NaH₂PO₄ with a pH that was previously adjusted to 4.5 with dilute phosphoric acid. The sample pretreatment was performed by treating the formulation with methanol followed by filtration. After method development, the influence of the different chromatographic parameters on the separation, the interference of other active compounds and excipients, linearity, accuracy, repeatability and intermediate precision were investigated. The method was shown to be selective, linear, accurate, precise and repeatable. Finally, the content of the compounds in the formulation was determined.     

The effect of cognitive behavioural therapy integrated with activity pacing on cancer-related fatigue,depression and quality of life among patients with breast cancer undergoing chemotherapy in Ethiopia: A randomised clinical trial

Fatigue is a common symptom experienced by 80% of individuals who receive chemotherapy and is one of the major factors that affect quality of life (QoL) of patients with breast cancer. Our study aimed to assess the effect of cognitive behavioural therapy integrated with activity pacing (CBT-AP) on cancer-related fatigue among patients with breast cancer undergoing chemotherapy. A parallel-group, randomised controlled trial was conducted. Severely fatigued patients were randomly assigned to the CBT-AP or usual care (UC) groups using a computer-generated random sequence. The new intervention was designed for seven sessions: three 2-hour face-to-face and four 30-minute telephone sessions. The primary outcome (fatigue severity) and the secondary outcomes (depression and QoL) were assessed at the end of the intervention and after 3 months. The data were analysed by repeated measures analyses of covariance (RM-ANCOVA). CBT-AP had a significant time effect (P < .001, ηp² = 0.233) in reducing fatigue from baseline (adjusted mean = 7.48) to the end of the intervention (adjusted mean = 6.37) and the 3-month follow-up (adjusted mean = 6.54). Compared to the UC group, the CBT-AP group had lower fatigue and depression scores, and higher global health status scores. The group × time interaction revealed a significant reduction in fatigue and depression in the CBT-AP group compared to the UC group. Therefore, CBT-AP appears to be effective in reducing fatigue and depression and improving QoL in patients with breast cancer undergoing chemotherapy. It is highly recommended to integrate a CBT-AP intervention in routine cancer care.     

Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure

Background  

Since only little is known on stem cell therapy in non-ischemic heart failure we wanted to know whether a long-term improvement of cardiac function in non-ischemic heart failure can be achieved by stem cell transplantation.     

原位聚合酶链反应检测石蜡包埋肺组织中巨细胞病毒

利用生物素标记核苷酸掺入示踪，成功地建立了巨细胞病毒原位聚合酶链反应方法。在石蜡包埋肺组织中检出巨细胞病毒，证实巨细胞病毒在肺内分布广泛，可感染多种细胞。本方法将聚合酶链反应的高度特异性及敏感性与组织结构密切地结合在一起，精确地显示了巨细胞病毒在肺组织中的分布特点，为从肺活检组织或支气管肺泡灌洗液中检出巨细胞病毒，从而准确地诊断巨细胞病毒肺炎提供了最新的方法。     

Collaborative studies of U.S.-China neurologists on acute motor axonal neuropathy

THE HISTORY AND FRIENDSHIP BETWEEN BEIJING CHILDREN’S HOSPITAL AND THE JOHNS HOPKINS HOSPITAL The founder of modern pediatric medicine in China and the first president of Beijing Children’s Hospital(BCH),academician of Chinese Academy of Sciences,Prof.Fu-Tang Chu(Prof.Futang Zhu’s name was spelled as Fu-Tang Chu since early 1930s until 1964,later on as universal use of Chinese Phonetic Alphabet for people’s name,his name has been spelled as Futang Zhu),developed a close relationship with his mentor,Prof.Charles F.McKhann,when he studied and worked in Boston Children’s Hospital,the teaching hospital of Harvard Medical School in Boston in the early 1930s.He also became a good friend of Prof.Guy M.McKhann(son of Prof.Charles F.McKhann),the founder and the first director of neurology at the Johns Hopkins Hospital(JHH)years later.     

The electrocardiogram in healthy northwest Ethiopians

The normal values for ECG have not been fully investigated on Ethiopians. This cross sectional study was conducted in 1999/2000 to obtain baseline ECG information on normal healthy northwest Ethiopians and to find out whether normal ranges of ECG parameters in our population differ from those of Caucasians or other black Africans. A standard 12-lead electrocardiogram was done in 690 selected healthy northwest Ethiopians. They were 392 (56.8%) male and 298 (43.2%) female with a median age of 23 years. The systolic and diastolic blood pressures were within the normal range in all subjects. The total incidence of deviation from the accepted normal ECG was recorded in 393 (57.0%) subjects. This was found in 294 (75.0%) male and 99 (33.2%) female subjects. The most common type of "abnormalities" were high peaked T wave, 104 (26.5%), elevated S-T segment, 70 (17.8%), and elevated ST segment with high peaked T wave, 32 (10.9%) in male and negative or flat T wave, 35 (11.7%) in female. All types of variations were more pronounced in young subjects of both sexes and less common in those aged 40 years and above. The normal ECG variants found in Ethiopians were similar to those found in other subjects of black African origin. In conclusion, the normal variants identified in this study must be taken into consideration in the interpretation of ECG from cardiac patients which prevents this useful test from being understood wrongly.