全文获取类型
收费全文 | 191篇 |
免费 | 25篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 11篇 |
基础医学 | 95篇 |
口腔科学 | 1篇 |
临床医学 | 7篇 |
内科学 | 26篇 |
神经病学 | 27篇 |
外科学 | 14篇 |
预防医学 | 22篇 |
眼科学 | 1篇 |
药学 | 11篇 |
出版年
2023年 | 1篇 |
2019年 | 2篇 |
2015年 | 1篇 |
2014年 | 2篇 |
2013年 | 7篇 |
2012年 | 7篇 |
2011年 | 11篇 |
2010年 | 9篇 |
2009年 | 14篇 |
2008年 | 8篇 |
2007年 | 7篇 |
2006年 | 8篇 |
2005年 | 14篇 |
2004年 | 9篇 |
2003年 | 6篇 |
2002年 | 9篇 |
2001年 | 7篇 |
2000年 | 9篇 |
1999年 | 14篇 |
1998年 | 3篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 1篇 |
1994年 | 5篇 |
1993年 | 1篇 |
1992年 | 5篇 |
1991年 | 1篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 5篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 1篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1932年 | 1篇 |
排序方式: 共有216条查询结果,搜索用时 15 毫秒
211.
The past few years have seen important developments in understanding the epidemiological and virological characteristics of rotaviruses, and rapid progress has been made in rotavirus vaccine development, but further challenges remain before a vaccine is introduced into widespread use. The licensure of the first rotavirus vaccine, a tetravalent rhesus-based rotavirus vaccine, in the United States in 1998, marked a significant advance in preventing the morbidity associated with rotavirus diarrhea. The association between the tetravalent rhesus-based rotavirus vaccine and intussusception has created significant hurdles as well as new opportunities to study the pathogenesis of rotavirus and rotavirus vaccine infection. Several other rotavirus vaccine candidates are in late stages of development, and results from trials have been encouraging. 相似文献
212.
213.
214.
Feuerbach D Lingenhoehl K Olpe HR Vassout A Gentsch C Chaperon F Nozulak J Enz A Bilbe G McAllister K Hoyer D 《Neuropharmacology》2009,56(1):254-263
Several lines of evidence suggest that the nicotinic acetylcholine receptor α7 (nAChR α7) is involved in central nervous system disorders like schizophrenia and Alzheimer's disease as well as in inflammatory disorders like sepsis and pancreatitis. The present article describes the in vivo effects of JN403, a compound recently characterized to be a potent and selective partial nAChR α7 agonist. JN403 rapidly penetrates into the brain after i.v. and after p.o. administration in mice and rats. In the social recognition test in mice JN403 facilitates learning/memory performance over a broad dose range. JN403 shows anxiolytic-like properties in the social exploration model in rats and the effects are retained after a 6 h pre-treatment period and after subchronic administration. The effect on sensory inhibition was investigated in DBA/2 mice, a strain with reduced sensory inhibition under standard experimental conditions. Systemic administration of JN403 restores sensory gating in DBA/2 mice, both in anaesthetized and awake animals. Furthermore, JN403 shows anticonvulsant potential in the audiogenic seizure paradigm in DBA/2 mice. In the two models of permanent pain tested, JN403 produces a significant reversal of mechanical hyperalgesia. The onset was fast and the duration lasted for about 6 h. Altogether, the present set of data suggests that nAChR α7 agonists, like JN403 may be beneficial for improving learning/memory performance, restoring sensory gating deficits, and alleviating pain, epileptic seizures and conditions of anxiety. 相似文献
215.
216.
Alexzandra T. Gentsch LSW Jonathan Butler PhD Kelli O'Laughlin MD MPH Stephanie A. Eucker MD PhD AnnaMarie Chang MD MSCE Herbie Duber MD MPH Rachel E. Geyer MPH Amanda Guth MPH Hemal K. Kanzaria MD Alena Pauley MScGH Kristin L. Rising MD MSHP Cecilia Lara Chavez Anna Tupetz DPT Robert M. Rodriguez MD 《Academic emergency medicine》2023,30(1):32-39