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81.
Aura AJ van Esch Mark P Lamberts René HM te Morsche Martijn GH van Oijen Jan BMJ Jansen Joost PH Drenth 《BMC gastroenterology》2009,9(1):97
Background
The major clinical feature in chronic pancreatitis is pain, but the genetic basis of pancreatic pain in chronic pancreatitis is poorly understood. The transient receptor potential vanilloid receptor 1 (TRPV1) gene has been associated with pain perception, and genetic variations in TRPV1 may modify the presence and phenotype of chronic pancreatitis. The aim of our study was to investigate the genetic variation of TRPV1 in Dutch patients with chronic pancreatitis and healthy controls. 相似文献82.
The joint effect of mood, task valence, and task difficulty on effort-related cardiovascular response and facial EMG 总被引:2,自引:0,他引:2
Nicolas Silvestrini Guido H.E. Gendolla 《International journal of psychophysiology》2009,73(3):226-234
This study investigated whether a pleasant task with high potential for mood regulation could eliminate the motivational deficit of people facing a difficult task in a negative mood. Cardiovascular and facial EMG reactivity of 88 University students were measured during habituation, mood inductions, and an either pleasant or unpleasant scenario completion task that was either easy or difficult. In the unpleasant condition cardiovascular reactivity was modest, particularly in the negative-mood/difficult condition. But when the task was pleasant, cardiovascular reactivity in the negative-mood/difficult condition was stronger than in all other conditions, reflecting the elimination of the motivational deficit. Moreover, facial EMG reactivity indicated efficient mood manipulations. In summary, the findings are interpreted as further support for the mood-behavior-model [Gendolla, G.H.E., 2000. On the impact of mood on behavior: an integrative theory and a review. Rev. Gen. Psychol. 4, 378–408]. 相似文献
83.
Marc?GH?BesselinkEmail author Harro?M?Timmerman Erik?Buskens Vincent?B?Nieuwenhuijs Louis?MA?Akkermans Hein?G?Gooszen the members of the Dutch Acute Pancreatitis Study Group 《BMC surgery》2004,4(1):12
Background
Infectious complications are the major cause of death in acute pancreatitis. Small bowel bacterial overgrowth and subsequent bacterial translocation are held responsible for the vast majority of these infections. Goal of this study is to determine whether selected probiotics are capable of preventing infectious complications without the disadvantages of antibiotic prophylaxis; antibiotic resistance and fungal overgrowth. 相似文献84.
85.
Two experiments with N = 221 university students investigated the impact of primed cognitive conflict on effort assessed as cardiac response in tasks that were not conflict-related themselves. Manifest cognitive conflict in cognitive control tasks is confounded with objective response difficulty (e.g., in incongruent Stroop task trials). This makes conclusions about the effortfulness of cognitive conflict itself difficult. We bypassed this problem by administrating pictures of congruent versus incongruent Stroop task stimuli as conflict primes. As predicted, primed cognitive conflict increased cardiac pre-ejection period (PEP) responses in an easy attention task in Experiment 1. Accordingly, cognitive conflict itself is indeed effortful. This effect was replicated in an easy short-term memory task in Experiment 2. Moreover, as further predicted, the primed cognitive conflict effect on PEP reactivity disappeared when participants could personally choose task characteristics. This latter effect corresponds to other recent evidence showing that personal action choice shields against incidental affective influences on action execution and especially on effort-related cardiovascular response. 相似文献
86.
研究纳入丹麦1997~2006年间107806例起始胰岛素促泌剂或二甲双胍单药治疗的2型糖尿病患者(年龄>20岁,没有使用过胰岛素单药和联合治疗)其中9607例患者既往存在心肌梗死史.随访时间3.3年,每3个月为一个区间,收集不同胰岛素促泌剂或二甲双胍的处方,如果某区间无处方量则以之前最多3个处方量的区间作为参考. 相似文献
87.
88.
89.
Acute lymphoblastic leukemia in infants: evidence for B cell origin of disease by use of monoclonal antibody phenotyping 总被引:1,自引:1,他引:0
Since the prognosis of infants with acute lymphoblastic leukemia (ALL) is so poor, it has been suggested that these leukemias may not be lymphoid in origin, but may originate from stem cell, myeloid, or megakaryocytic progenitors. Alternately it has been hypothesized that these leukemias originate in lymphoid cells at the earliest stages of B cell development. Another possibility is that these leukemias may be of more than one lineage. Therefore we examined leukemic blasts from 12 infants with ALL using monoclonal antibodies to myeloid and lymphoid differentiation antigens. The majority of specimens expressed HLA/DR and reacted with B4 (CD19) but failed to react with stem cell, myeloid, megakaryocytic, or T cell associated antibodies. These results support the speculation that the majority of these leukemias arise in cells at the earliest stages of B cell commitment, and are not of a myeloid or biphenotypic nature. 相似文献
90.
苯甲酰胺类抗精神病药物的研究:若干3α-去甲托品烷衍生物的合成 总被引:1,自引:0,他引:1
Reductive amination of8- benzyl-nortropinone(3 )with ammonium acetate andsodium cyanoborohydride yielded the 3 α-amino nortropane derivative 4 which was condensed withsubstituted benzoic acids using 2-bromo-N-methyl-pyridinium iodide as condensing reagent to give thetarget compounds 2a~ein an overall yield of 50~60%.Compound 2e showed marked and selectiveaffinity for D-2 receptor.Compound 2d showed definite affinity for D- 1 receptor besides markedaffinity for D-2 receptor. 相似文献