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61.
Are 5‐HT3 antagonists effective in obsessive–compulsive disorder? A systematic review of literature
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Daniele Serata Georgios D. Kotzalidis Chiara Rapinesi Delfina Janiri Simone Di Pietro Gemma Callovini Daria Piacentino Carlotta Gasperoni Roberto Brugnoli Vittoria Rachele Ferri Nicoletta Girardi Roberto Tatarelli Stefano Ferracuti Gloria Angeletti Paolo Girardi Antonio Del Casale 《Human psychopharmacology》2015,30(2):70-84
62.
Yevheniia Mikheenko Yoshiro Shiba Stephen Sawiak Katrin Braesicke Gemma Cockcroft Hannah Clarke Angela C Roberts 《Neuropsychopharmacology》2015,40(6):1395-1404
Trait anxiety is a risk factor for the development and maintenance of affective disorders, and insights into the underlying brain mechanisms are vital for improving treatment and prevention strategies. Translational studies in non-human primates, where targeted neurochemical and genetic manipulations can be made, are critical in view of their close neuroanatomical similarity to humans in brain regions implicated in trait anxiety. Thus, we characterised the serotonergic and regional brain volume correlates of trait-like anxiety in the marmoset monkey. Low- and high-anxious animals were identified by behavioral responses to a human intruder (HI) that are known to be sensitive to anxiolytic drug treatment. Extracellular serotonin levels within the amygdala were measured with in vivo microdialysis, at baseline and in response to challenge with the selective serotonin reuptake inhibitor, citalopram. Regional brain volume was assessed by structural magnetic resonance imaging. Anxious individuals showed persistent, long-term fearful responses to both a HI and a model snake, alongside sustained attention (vigilance) to novel cues in a context associated with unpredictable threat. Neurally, high-anxious marmosets showed reduced amygdala serotonin levels, and smaller volumes in a closely connected prefrontal region, the dorsal anterior cingulate cortex. These findings highlight behavioral and neural similarities between trait-like anxiety in marmosets and humans, and set the stage for further investigation of the processes contributing to vulnerability and resilience to affective disorders. 相似文献
63.
Pelargonio Gemma Di Monaco Antonio Guida Pietro Pellegrino Pier Luigi Vergara Pasquale Grimaldi Massimo Narducci Maria Lucia Tritto Massimo 《Journal of interventional cardiac electrophysiology》2022,63(1):125-132
Journal of Interventional Cardiac Electrophysiology - Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, occurring in 1–2% of the general population. Catheter ablation... 相似文献
64.
Francesco Solimene MD Mario Giannotti Santoro MD Antonio De Simone MD Maurizio Malacrida MSc Giuseppe Stabile MD Claudio Pandozi MD Gemma Pelargonio PhD MD Filippo Maria Cauti MD Marco Scaglione MD Domenico Pecora MD Maria Grazia Bongiorni MD Alberto Arestia MD Gabriella Grimaldi MD Maurizio Russo MD Maria Lucia Narducci PhD MD Luca Segreti MD 《Journal of cardiovascular electrophysiology》2021,32(6):1540-1548
65.
Francis Dziva Heidi Hauser Thomas R. Connor Pauline M. van Diemen Graham Prescott Gemma C. Langridge Sabine Eckert Roy R. Chaudhuri Christa Ewers Melha Mellata Suman Mukhopadhyay Roy Curtiss III Gordon Dougan Lothar H. Wieler Nicholas R. Thomson Derek J. Pickard Mark P. Stevens 《Infection and immunity》2013,81(3):838-849
Avian pathogenic Escherichia coli (APEC) causes respiratory and systemic disease in poultry. Sequencing of a multilocus sequence type 95 (ST95) serogroup O1 strain previously indicated that APEC resembles E. coli causing extraintestinal human diseases. We sequenced the genomes of two strains of another dominant APEC lineage (ST23 serogroup O78 strains χ7122 and IMT2125) and compared them to each other and to the reannotated APEC O1 sequence. For comparison, we also sequenced a human enterotoxigenic E. coli (ETEC) strain of the same ST23 serogroup O78 lineage. Phylogenetic analysis indicated that the APEC O78 strains were more closely related to human ST23 ETEC than to APEC O1, indicating that separation of pathotypes on the basis of their extraintestinal or diarrheagenic nature is not supported by their phylogeny. The accessory genome of APEC ST23 strains exhibited limited conservation of APEC O1 genomic islands and a distinct repertoire of virulence-associated loci. In light of this diversity, we surveyed the phenotype of 2,185 signature-tagged transposon mutants of χ7122 following intra-air sac inoculation of turkeys. This procedure identified novel APEC ST23 genes that play strain- and tissue-specific roles during infection. For example, genes mediating group 4 capsule synthesis were required for the virulence of χ7122 and were conserved in IMT2125 but absent from APEC O1. Our data reveal the genetic diversity of E. coli strains adapted to cause the same avian disease and indicate that the core genome of the ST23 lineage serves as a chassis for the evolution of E. coli strains adapted to cause avian or human disease via acquisition of distinct virulence genes. 相似文献
66.
Objective
Attachment style and emotional intelligence (EI) have been highlighted as potential factors influencing the variation in medical students’ and doctors’ patient–provider communication (PPC), particularly in relation to emotive issues. The objective of this review is to systematically review and synthesise the published literature relating to the influence of medical students’ and/or doctors’ attachment style and EI on their PPC.Methods
Electronic and hand searches were conducted to identify all published literature relating to the aim of the review. Data were narratively synthesised.Results
1597 studies were identified. 14 were included in the review, of which 5 assessed the influence of attachment style and 9 assessed the influence of EI on PPC. No studies assessed the impact of both attachment style and EI on PPC.Conclusion
Whilst tentative links were found between both PPC and both attachment style and EI, heterogeneity in study design, predictor variables and outcome measures made drawing conclusions difficult.Practice implications
More research is needed to assess the influence of both attachment style and EI on PPC. 相似文献67.
68.
Dolors Costa Concha Muoz Ana Carri Meritxell Nomdedeu Xavier Calvo Francesc Sol Elisa Luo Jos Cervera Teresa Vallespí Daniela Berneaga Cndida Gmez Amparo Arias Esperanza Such Guillermo Sanz Javier Grau Andrs Insunza María J. Calasanz María T. Ardaaz Jesús M. Hernndez Gemma Azaceta Sara lvarez Joaquín Snchez María L. Martín Joan Bargay Valle Gmez Carlos Javier Cervero María J. Allegue Rosa Collado Elias Campo Benet Nomdedeu 《Genes, chromosomes & cancer》2013,52(8):753-763
The infrequency of translocations in myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemias (CMML) makes their identification and reporting interesting for the recognition of the recurrent ones and the genes involved in these neoplasias. The aims of this study were to identify new translocations associated with MDS and CMML and to establish their frequency in a cohort of 8,016 patients from the Spanish Group of MDS database. The karyotype was evaluable in 5,654 (70%) patients. Among those, 2,014 (36%) had chromosomal abnormalities, including 213 (10%) translocations identified in 195 patients. The translocations were balanced in 183 (86%) cases and unbalanced in 30 (14%) cases. All chromosomes were found to be involved in translocations, with the single exception of the Y chromosome. The chromosomes most frequently involved were in decreasing frequency: 3, 1, 7, 2, 11, 5, 12, 6, and 17. Translocations were found in karyotypes as the unique chromosomal abnormality (33%), associated with another chromosomal abnormality (11%), as a part of a complex karyotype (17%), and as a part of a monosomal karyotype (38%). There were 155 translocations not previously described in MDS or CMML and nine of them appeared to be recurrent. © 2013 Wiley Periodicals, Inc. 相似文献
69.
Sonsire Fernández Esther M Fajardo Aleida Mandiarote Gemma Año Maria A Padrón Michel Acosta Rubén A Cabrera Luis A Riverón Maydelis Álvarez Kirenia Blaín Mildrey Fariñas Daniel Cardoso Luis G García Concepción Campa José L Pérez 《BMC immunology》2013,14(Z1):S8
Whooping cough remains a health problem despite high vaccination coverage. It has been recommended that development of new strategies provide long-lasting immunity. The aim of this work was to evaluate the potential of proteoliposomes (PL) extracted from Bordetella pertussis as a vaccine candidate against whooping cough. The size of the B. pertussis PL was estimated to be 96.7±50.9 nm by Scanning Correlation Spectroscopy and the polydispersity index was 0.268. Western blots using monoclonal antibodies revealed the presence of pertussis toxin, pertactin, and fimbriae 3. The Limulus Amebocyte Lisate (LAL) assay showed endotoxin levels lower than those reported for whole cell pertussis licensed vaccines, while the Pyrogen Test indicated 75 ng/mL/Kg. The PL showed high protection capacity in mouse challenge models. There was 89.7% survival in the intracerebral challenge and total reduction of the number of CFU in the intranasal challenge. No significant differences (p>0.05) were observed between mice immunized with B. pertussis PL and the Cuban DTwP vaccine, whichever challenge model used. These results encouraged us to continue the development of the B. pertussis PL as a component of a new combined vaccine formulated with tetanus and diphtheria toxoids or as a booster dose for adolescents and adults. 相似文献
70.