全文获取类型
收费全文 | 2304篇 |
免费 | 131篇 |
国内免费 | 115篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 105篇 |
妇产科学 | 26篇 |
基础医学 | 218篇 |
口腔科学 | 36篇 |
临床医学 | 329篇 |
内科学 | 502篇 |
皮肤病学 | 40篇 |
神经病学 | 90篇 |
特种医学 | 377篇 |
外国民族医学 | 1篇 |
外科学 | 199篇 |
综合类 | 62篇 |
预防医学 | 293篇 |
眼科学 | 18篇 |
药学 | 147篇 |
中国医学 | 2篇 |
肿瘤学 | 93篇 |
出版年
2021年 | 23篇 |
2020年 | 17篇 |
2019年 | 19篇 |
2018年 | 26篇 |
2016年 | 36篇 |
2015年 | 36篇 |
2014年 | 40篇 |
2013年 | 64篇 |
2012年 | 48篇 |
2011年 | 65篇 |
2010年 | 65篇 |
2009年 | 69篇 |
2008年 | 59篇 |
2007年 | 107篇 |
2006年 | 72篇 |
2005年 | 88篇 |
2004年 | 58篇 |
2003年 | 54篇 |
2002年 | 53篇 |
2001年 | 38篇 |
2000年 | 43篇 |
1999年 | 37篇 |
1998年 | 105篇 |
1997年 | 109篇 |
1996年 | 109篇 |
1995年 | 72篇 |
1994年 | 74篇 |
1993年 | 71篇 |
1992年 | 38篇 |
1991年 | 51篇 |
1990年 | 55篇 |
1989年 | 76篇 |
1988年 | 54篇 |
1987年 | 61篇 |
1986年 | 42篇 |
1985年 | 57篇 |
1984年 | 31篇 |
1983年 | 37篇 |
1982年 | 34篇 |
1981年 | 25篇 |
1980年 | 38篇 |
1979年 | 25篇 |
1978年 | 23篇 |
1977年 | 23篇 |
1976年 | 29篇 |
1975年 | 22篇 |
1973年 | 11篇 |
1930年 | 12篇 |
1927年 | 10篇 |
1926年 | 11篇 |
排序方式: 共有2550条查询结果,搜索用时 265 毫秒
101.
102.
The objective of this systematic review was to assess the published literature on the effectiveness of exenatide twice daily (exenatide) in clinical practice, specifically its effects on haemoglobin A1c (A1C), fasting glucose (FG), weight, systolic blood pressure (SBP), medication use, hospitalization and cardiovascular disease (CVD) outcomes. A systematic literature search using the MEDLINE database of English language literature published between January 2005 and May 2011 was performed. The review included retrospective or prospective observational studies that included 100 or more patients per treatment group. A total of 15 studies meeting the inclusion criteria were identified. The studies revealed significant reductions of -0.4 to -0.9% in A1C, -10 mg/dl in FG, -2 to -11 kg in body weight and -2 to -11 mmHg in SBP. Statistically significant reductions in the use or dosage of either oral glucose-lowering medications or insulin after initiating exenatide treatment were found in every observational study that assessed medication changes, including reductions in dosage of up to 75% in sulphonylureas dosages, 22% in metformin, 66% in thiazolidinediones (TZD) or TZD combination therapy and 75% in prandial insulin. Exenatide-treated patients experienced significantly lower rates of all-cause and CVD-related hospitalization and CVD events than patients treated with other therapies overall. In this review of observational studies, exenatide initiation was associated with significant reductions in clinically relevant outcomes. Improvements in A1C, FG, weight and SBP in the observational studies in this review were consistent with improvements observed in controlled clinical trials. 相似文献
103.
104.
105.
Stephania Donayre Pimentel Heather Adams Tamara Ellis Robin Clark Craig Sully Catherine Paré Michael JL. Sullivan 《Journal of traumatic stress》2020,33(5):731-740
Catastrophizing has been discussed as a cognitive precursor to the emergence of posttraumatic stress disorder (PTSD) symptoms following the experience of stressful events. Implicit in cognitive models of PTSD is that treatment-related reductions in catastrophizing should yield reductions in PTSD symptoms. The tenability of this prediction has yet to be tested. The present study investigated the sequential relation between changes in a specific form of catastrophizing—symptom catastrophizing—and changes in PTSD symptom severity in a sample of 73 work-disabled individuals enrolled in a 10-week behavioral activation intervention. Measures of symptom catastrophizing and PTSD symptom severity were completed at pre-, mid-, and posttreatment assessment points. Cross-sectional analyses of pretreatment data revealed that symptom catastrophizing accounted for significant variance in PTSD symptom severity, β = .40, p < .001, sr = .28 (medium effect size), even when controlling for known correlates of symptom catastrophizing, such as pain and depression. Significant reductions in symptom catastrophizing and PTSD symptoms were observed during treatment, with large effect sizes, ds = 1.42 and 0.94, respectively, ps < .001. Cross-lagged analyses revealed that early change in symptom catastrophizing predicted later change in PTSD symptoms; early changes in PTSD symptom severity did not predict later change in symptom catastrophizing. These findings are consistent with the conceptual models that posit a causal relation between catastrophizing and PTSD symptom severity. The clinical implications of the findings are discussed. 相似文献
106.
107.
JL Adams M Murray N Patel MT Sawkin RC Boardman C Pham H Kaur D Patel JL Yager L Pontiggia J Baxter 《HIV medicine》2021,22(1):28-36
108.
巨噬细胞迁移抑制因子最初是由于能抑制体外巨噬细胞随机迁移而被发现,现在它作为一种重要的调节因子参与一系列炎症性疾病过程.我们最近发现,巨噬细胞迁移抑制因子的缺失使一些由炎症介质诱发的白细胞-内皮细胞相互作用减弱,提示巨噬细胞迁移抑制因子在炎症反应中起作用的机制之一是促进白细胞聚集.…… 相似文献
109.
Michon J; Moutel S; Barbet J; Romet-Lemonne JL; Deo YM; Fridman WH; Teillaud JL 《Blood》1995,86(3):1124-1130
Neutrophils isolated from cancer patients treated with granulocyte colony-stimulating factor (G-CSF) express high levels of Fc gamma RI. They exhibited an efficient killing of GD2+ neuroblastoma cells in the presence of an antidisialoganglioside (GD2) mouse monoclonal antibody (MoAb; 7A4, IgG3 kappa). However, this cytotoxicity was totally blocked by human monomeric IgG. In contrast, a bispecific antibody (7A4 bis 22/MDX-260), prepared by chemically linking an F(ab') fragment of 7A4 with an F(ab') fragment of an anti-Fc gamma RI MoAb, 22, which binds outside the Fc binding domain, triggered antibody-dependent cell cytotoxicity, even when neutrophils were preincubated with human monomeric IgG. F(ab')2 22 MoAb abrogated the MDX-260 killing without affecting that of 7A4. The 3G8 MoAb, directed against the Fc gamma RIII binding site, did not inhibit the cytotoxicity induced by either antibody. Thus, these results indicate that G-CSF-activated neutrophils exert their cytotoxic effect against neuroblastoma cells through Fc gamma RI and not Fc gamma RIII, and that the saturation of the high affinity Fc gamma RI by monomeric IgG can be overcome by the use of bispecific antibodies binding epitopes outside the IgG Fc gamma RI binding site. A combined administration of such bispecific antibodies and G-CSF may be, therefore, an efficient therapeutic approach to trigger tumor lysis by cytotoxic neutrophils in vivo. 相似文献
110.