International Urology and Nephrology - There are less scar formations in some wounds after wound repair. Our earlier study had shown that the amount of collagen fibers in canine prostatic urethra... 相似文献
Optimization of maintenance immunosuppression (mIS) regimens in the transplant recipient requires a balance between sufficient potency to prevent rejection and avoidance of excessive immunosuppression to prevent toxicities and complications. The optimal regimen after simultaneous liver-kidney (SLK) transplantation remains unclear, but small single-center reports have shown success with steroid-sparing regimens. We studied 4184 adult SLK recipients using the Scientific Registry of Transplant Recipients, from March 1, 2002, to February 28, 2017, on tacrolimus-based regimens at 1 year post-transplant. We determined the association between mIS regimen and mortality and graft failure using Cox proportional hazard models. The use of steroid-sparing regimens increased post-transplant, from 16.1% at discharge to 88.0% at 5 years. Using multi-level logistic regression modeling, we found center-level variation to be the major contributor to choice of mIS regimen (ICC 44.5%; 95% CI: 36.2%-53.0%). In multivariate analysis, use of a steroid-sparing regimen at 1 year was associated with a 21% decreased risk of mortality compared to steroid-containing regimens (aHR 0.79, P = .01) and 20% decreased risk of liver graft failure (aHR 0.80, P = .01), without differences in kidney graft loss risk (aHR 0.92, P = .6). Among SLK recipients, the use of a steroid-sparing regimen appears to be safe and effective without adverse effects on patient or graft survival. 相似文献
结果:免疫组化和免疫荧光染色结果显示,汉族患者小梁组织中TGF-β2表达明显高于哈萨克族患者。ELISA定量分析显示,汉族和哈萨克族患者房水中aTGF-β2含量(172.015±79.367、83.436±41.743pg/mL)有明显差异(t=4.794,P<0.001),且年龄≥70岁的两民族患者房水中tTGF-β2含量(480.124±152.997、338.858±72.497pg/mL)有差异(t=2.421,P=0.026)。术后两民族患者眼压均较术前明显降低,但术后6mo汉族和哈萨克族患者功能性滤过泡(Ⅰ、Ⅱ型滤过泡)形成情况有明显差异(50% vs 78%; χ2=4.841,P=0.028)。