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81.
82.
Jyh-Pyng Gau Chih-Cheng Chen Hui-Chi Hsu Chao-Hung Ho Wing-Keung Chau Jie-Yu You Yuan-Bin Yu 《Blood coagulation & fibrinolysis》2006,17(1):53-56
Nucleotide 6724 of the factor VIII gene harbors a polymorphism of low frequency. A report from Taiwan claimed that 97.9% of the 83 alleles examined were of the A nucleotide at this position, which is quite different to the data from Western populations. Furthermore, this nucleotide is the start of exon 25, located in juxtaposition to the splicing acceptor of intron 24. We wonder if the nucleotide change at this location might have any effect on the splicing process of pre-mRNA. Using genomic DNA with direct sequencing of the polymerase chain reaction-amplified intron 24/exon 25 junction site, we found that 59 of the 60 patient samples were of the GTG sequence at nucleotides 6724-6726. The polymorphism is similar between populations in Taiwan and Western countries. The sequence of intron 24 around the splicing acceptor was always TCCAACTCTATTGCCCTCAG (-20 to -1), except for one hemophiliac patient who had a mutation in which the absolute consensus AG doublet of the intron 24 splicing acceptor changed to the AA dinucleotide. Owing to the mutation, exon 24 was erroneously spliced to exon 26, and exon 25 was skipped. This finding further testifies to the importance of the invariant AG dinucleotide in the example of the factor VIII gene. 相似文献
83.
目的:探讨奎的平、氯氮平对精神分裂症的疗效及副作用。方法:80例患者随机分为两组,分别应用奎的平或氯氮平治疗6周,采用四级临床疗效评定标准、阳性症状与阴性症状量表(PANSS)、副反应量表(TESS)评定疗效及副反应。结果:奎的平组有效率87.5%,氯氮平组有效率82.5%。治疗第一周末,奎的平组PANSS量表总分较治疗前差异有显著性(P<0.05)。奎的平组副反应低于氯氮平组。结论:奎的平与氯氮平疗效相似,但奎的平起效较快,副反应较轻。 相似文献
84.
研究了77例长沙地区孕、产妇的宫颈排毒(CMV)情况及母、婴的免疫状态,并对宫颈排毒及CMV一IgM阳性的母亲所生小孩进行临床追踪。结果显示:孕妇宫颈排毒率为4.5%,抗CMV-IgG和抗CMV-IgM阳性率分别为77%和13%,59例脐血CMV-IgM阴性。宫颈排毒的3例其抗体检测抗CMV-IgG均阳性,抗CMV-IgM仅一例阳性。作者认为,对妊娠期活动性CMV感染的诊断,仅检测抗CMV-IgG和抗CMV-IgM抗体滴度仍不足,尚须结合病毒分离和其它检测手段。 相似文献
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86.
实验性蛛网膜下腔出血后脑血管痉挛兔海马组织中Bcl-2和Bax mRNA的表达 总被引:6,自引:2,他引:4
目的:探讨蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)造成脑损伤的机制.方法:用反转录聚合酶链式反应(RT—PCB)技术检测兔SAH后CVS时海马组织Bcl—2和BaxmRNA的表达变化.结果:Bcl—2mBNA的表达水平在SAH组1d时即开始下降,3d时降至最低,持续至7d.SAH组海马组织中BaxmRNA的表达呈上升趋势,3d时达最高,7d时仍显著高于正常组.在假手术组海马组织内的Bcl—2和BaxmRNA的表达水平保持相对恒定.结论:Bcl—2和Bax可能参与了SAH后CVS所造成的海马神经元损伤过程。 相似文献
87.
88.
类风湿性关节炎的肺部表现 总被引:1,自引:0,他引:1
本文对30例类风湿性关节炎患者中合并肺部损害的6例患者进行报道。其肺部的主要临床表现为胸痛、咳嗽、气短、长期低热及呼吸困难。体征主要为肺部干湿性罗音及胸膜摩擦音。胸部X线检查可见胸腔积液、胸膜肥厚粘连,弥漫性间质性肺纤维化、间质性肺炎。实验室检查可有嗜酸性粒细胞增高、类风湿因子阳性、血沉增快、免疫球蛋白增高等。本文并对类风湿性关节炎合并肺部病变的发生机理进行了初步探讨。 相似文献
89.
BACKGROUND:Wilson disease (WD)damages liver,brain,kidney,cornea and nervous system severely.It is manifested in four ways:brain,liver,kidney and bone muscle.Whether or not magnetic resonance imagling (MRI)can clearly display the diseased region and range in brain of patient with WD,which provides imageological evidence for clinical practice,is unclear.OBJECTIVE:To observe the charactedstics of MRI of brain in patient with SD,and analyze the correlation of diseased region with clinical symptoms.DESIGN:Retrospective case-analysis.SETTING:Department of Radiology,Second Hospital Affiliated to the General Hospital of Chinese PLA.PARTICIPANTS:Thirty-one patients,including 18 males and 13 females,with WD admitted to the Department of Neurology,Second Hospital Affiliated to the General Hospital of Chinese PLA between January 1999and December 2005 were retrieved.The involved patients presented serum copper oxidase (sCP) activity decreasling and/or caruloplasmin Ievel decreasling and/or urinary copper content increasling;typical extrapyramidal symptoms and/or physical sign;abnormality showed by slit-lamp examination,Kayser-Fleischer rling positive.METHODS:①All the involved patients underwent MRI examination.A GE 1.5T imagling equipment was used.Spin-echo sequence was adopted to perform T2 and T1-weighed image at transverse axis level.Partial cases subjected to head scannling at coronal and/or sagittal level.Gd-DTPA With dosage of 0.1 mmol/kg was the strongest in 4 cases.②MRI characteristics of patients with dliferent clinical symptoms were observed.MAIN OUTCOME MEASURES:MRI detection results of patients with WD and MRI characteristics of patients with different clinical symptoms.RESULTS:Thirty-one patients with WD participated in the result analysis.①Imageological examination results:WD lnvolved many regions in the brain:dorsal caudate putamen(n=28),thalamencephalon(n=25),mesencaphalon(n=25),globus pallidus(n=23),pons(n=21),posterlor limb of intemal capsule(n=16),dentate nucleus(n=16),caudata nucleus(n=15)and cerebral cortex(n=11).MRI presented hypo-intensity signal on T2-weighted image and T1-weighted image or isointensity signal on T1-weighted image in 24 patients,characteristic hypo-intensity signal of globus pallidus in 4 patients,mixed signal of hyper-and hypo-intensity in 2 patients,hypo-intensity signal of globus pallidus,pars anterior pedunculi carebd and pontine tegmentum on T1-weighted image in 1 patient.Pathological changes distdbuted in symmetry and focus of infection mostly presented mottling,lamellar or strip.Different degrses of cerebral cortex atrophy,especially subtentodal cerebellar atrophy,ware found in 20 patients.Four patients subjected to enhancement scannling,but no clear imaqling was found.③MRI characteristics of patients with different symptoms:Abnormal signal of dorsal caudate putamen was found in 28 patients with dystonia,21 patients with dysarthda and 16 patients with bradykinesia;Abnormal signal of mesencaphalon was found in 22 patients with trepidation,among which,18 presented abnormal signal of pons;Abnormal signal of caudate nucleus and lenticular nucleus was found in 15 patients with dysphagia;Abnormal signal of dentate nucleus was found in 16 patients with carebellar ataxia;Different degrees of changes in cerebral atrophy were found in 14 patients with detedoratling memory and dementia.CONCLUSION:MRI can clearly display the characteristics of diseased regions in brain of patient with WD.Diseased regions reflected by MRI have obvious differences in patients with different clinical neurosigns. 相似文献
90.