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排序方式: 共有265条查询结果,搜索用时 15 毫秒
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Linnea Stridh Peter LP Smith Andrew S Naylor Xiaoyang Wang Carina Mallard 《Journal of neuroinflammation》2011,8(1):45
Background
Hypoxic-ischemic (HI) brain injury remains a major problem in newborns, resulting in increased risk of neurological disorders. Neonatal HI triggers a broad inflammatory reaction in the brain, including activation of the innate immune system. Toll-like receptors (TLRs), which are key components of the innate immune system, are believed to play a role in adult cerebral ischemic injury. The expression of TLRs in the neonatal brain and their regulation after HI is unknown. 相似文献44.
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Le Blanche AF Benazzouz A Reynaud P Fernandez RO Emanuelli G Ricco JB Delcour C;European VenaTech LP Vena Cava Filter Study Group 《Journal of vascular and interventional radiology : JVIR》2008,19(4):509-515
PURPOSE: To evaluate (i) the appropriateness, safety, and patient outcomes after placement of the VenaTech LP caval filter and (ii) the success of filter insertion through various venous access routes. MATERIALS AND METHODS: An open multicenter prospective observational study was conducted in 12 European centers, including an initial part limited to four centers. Patients with common indications were eligible for inclusion after approval by an independent ethics committee. Over a 42-month period, 106 patients (46 men [43.4%], 60 women [56.6%]), 72.2 years +/- 13.3 of age (range, 37-97 y), with poor prognoses were included. Patients were examined 2-5 days after the procedure, then at 30 days +/- 5 and 90 days +/- 15 for clinical follow-up and filter assessment. Evaluation criteria were based on occurrence of pulmonary embolism (PE), adverse events, death, filter position, and caval patency. Data were available in 101 case report forms at days 2-5, in 75 at day 30 +/- 5, and in 60 at day 90 +/- 15. Two patients (1.9%) were lost to follow-up. RESULTS: The overall mortality rate was 20.8%. PE was present in 71 patients (67.0%). History of venous thromboembolic disease (VTED) was noted in 32 patients (30.2%), and recently diagnosed VTED was present in 101 patients (95.3%). Partial caval thrombosis was present before the procedure. Filter tilting of 10-45 degrees was seen in 3.9% of cases at days 2-5, 4.3% of cases at day 30 +/- 5, and 1.9% of cases at day 90 +/- 15. Follow-up evidenced neither clinical signs of PE nor significant device-related events. CONCLUSIONS: In a prospective patient cohort with a projected 3-month mortality rate of nearly 21.0% as a result of severe prognoses, the success of insertion via various venous access routes and the appropriateness and safety of the VenaTech LP caval filter were assessed. Findings at 90-day follow-up were free of symptomatic PE and device-related adverse effects. 相似文献
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Annette J Browne Gweneth Hartrick Doane Joanne Reimer Martha LP MacLeod Edna McLellan 《Nursing inquiry》2010,17(1):27-38
BROWNE AJ, HARTRICK DOANE G, REIMER J, MacLEOD MLP and McLELLAN E. Nursing Inquiry 2010; 17 : 27–38
Public health nursing practice with 'high priority' families: the significance of contextualizing 'risk'
Public health nurses (PHNs) play a vital role in supporting families at risk; few studies, however, have focused on how PHNs actually work with families to provide support, build trust, and use their clinical judgment to make decisions in complex, at-risk situations. In this study, we report on findings from research that illustrate how PHNs use relational approaches in their work with 'high priority' families. Drawing on data collected from interviews and focus groups with 32 PHNs, we discuss three central features inherent to working relationally with families at risk: (i) contextualizing the complexities of families' lives; (ii) responding to shifting contexts of risk and capacity; and (iii) working relationally with families under surveillance. These findings show that the ability to recognize risk and capacity as intersecting aspects of families' lives, and to practice from a stance that recognizes risk as contextualized is foundational to effective working relationships with high-priority families. 相似文献
Public health nursing practice with 'high priority' families: the significance of contextualizing 'risk'
Public health nurses (PHNs) play a vital role in supporting families at risk; few studies, however, have focused on how PHNs actually work with families to provide support, build trust, and use their clinical judgment to make decisions in complex, at-risk situations. In this study, we report on findings from research that illustrate how PHNs use relational approaches in their work with 'high priority' families. Drawing on data collected from interviews and focus groups with 32 PHNs, we discuss three central features inherent to working relationally with families at risk: (i) contextualizing the complexities of families' lives; (ii) responding to shifting contexts of risk and capacity; and (iii) working relationally with families under surveillance. These findings show that the ability to recognize risk and capacity as intersecting aspects of families' lives, and to practice from a stance that recognizes risk as contextualized is foundational to effective working relationships with high-priority families. 相似文献
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肿节风片的质量标准研究 总被引:9,自引:0,他引:9
目的:制订肿节风片质量标准。方法:紫外分光光度法测定了总黄酮的含量,对肿风药材进行了薄层色谱鉴别。结果:加标回收率平均98.1%(RSD=2.3%,n=6),r=0.99996,重复性RSD=1.23%(n=6),精密度RSD=1.14%,结论:方法稳定,可靠,可作为该制剂的质量控制方法之一。 相似文献
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灯盏花素对豚鼠单一心室肌细胞ICa的抑制作用 总被引:25,自引:0,他引:25
目的:观察灯盏花素对豚鼠单一心室肌细胞钙离子电流(ICa)的影响。方法:应用全细胞膜片钳制技术。结果:灯盏花素能明显抑制心室肌细胞的Ca^2+通道,使ICa减小。此作用有明显的电压依赖性。在峰电流电压下作用最明显,而对其反转电位无明显影响。在指令电位0mV时,0.5mg%灯盏花素使ICa减小5.4%,1mg%灯盏花素使ICa减小22.9%(P〈0.01),2mg%灯盏花素使ICa减小45.0%(P 相似文献
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脂质体载水溶性药物出现的共同问题是药物的包封量低、稳定性差。本文以甲硝唑(Ⅰ)为水溶性药物模型,进行疏水性结构修饰,得其肉豆蔻酸酯(Ⅱ)前体药物,分别进行Ⅰ和Ⅱ的脂质体研究,结果表明Ⅱ在脂质体中的包封率较Ⅰ提高10倍以上,渗漏速率降至十分之一,制成含Ⅱ的脂质干膜,经超声分散,可得合乎要求的重组型脂质体,为解决脂质体载药的稳定性问题提供有效途径。体外抗阿米巴原虫试验,镜检观察到载药脂质体进入阿米巴原虫的细胞内,且100%抑制原虫所需剂量Ⅱ脂质体是Ⅰ游离药的二分之一。因此药物疏水化修饰是解决脂质体载水溶性药物稳定性问题的理想途径。 相似文献