全文获取类型
收费全文 | 8663篇 |
免费 | 477篇 |
国内免费 | 96篇 |
专业分类
耳鼻咽喉 | 70篇 |
儿科学 | 293篇 |
妇产科学 | 194篇 |
基础医学 | 1189篇 |
口腔科学 | 224篇 |
临床医学 | 735篇 |
内科学 | 1984篇 |
皮肤病学 | 199篇 |
神经病学 | 944篇 |
特种医学 | 583篇 |
外科学 | 921篇 |
综合类 | 60篇 |
预防医学 | 416篇 |
眼科学 | 185篇 |
药学 | 558篇 |
中国医学 | 39篇 |
肿瘤学 | 642篇 |
出版年
2024年 | 14篇 |
2023年 | 84篇 |
2022年 | 151篇 |
2021年 | 242篇 |
2020年 | 137篇 |
2019年 | 194篇 |
2018年 | 259篇 |
2017年 | 191篇 |
2016年 | 203篇 |
2015年 | 251篇 |
2014年 | 293篇 |
2013年 | 375篇 |
2012年 | 567篇 |
2011年 | 583篇 |
2010年 | 390篇 |
2009年 | 363篇 |
2008年 | 518篇 |
2007年 | 551篇 |
2006年 | 555篇 |
2005年 | 516篇 |
2004年 | 499篇 |
2003年 | 472篇 |
2002年 | 411篇 |
2001年 | 97篇 |
2000年 | 75篇 |
1999年 | 107篇 |
1998年 | 133篇 |
1997年 | 117篇 |
1996年 | 102篇 |
1995年 | 77篇 |
1994年 | 68篇 |
1993年 | 71篇 |
1992年 | 39篇 |
1991年 | 39篇 |
1990年 | 30篇 |
1989年 | 55篇 |
1988年 | 75篇 |
1987年 | 43篇 |
1986年 | 34篇 |
1985年 | 39篇 |
1984年 | 22篇 |
1983年 | 18篇 |
1982年 | 22篇 |
1981年 | 17篇 |
1980年 | 14篇 |
1979年 | 18篇 |
1978年 | 12篇 |
1977年 | 15篇 |
1976年 | 13篇 |
1970年 | 10篇 |
排序方式: 共有9236条查询结果,搜索用时 15 毫秒
141.
N Marziliano PA Merlini G Vignati F Orsini V Motta L Bandiera M Intrieri S Veronese 《Neonatology》2012,102(4):254-258
Hypertrophic cardiomyopathy (HCM) is a familial, genetically determined, primary cardiomyopathy caused by mutations in genes coding for proteins of the sarcomere, or, less frequently, genes involved in storage diseases. In pediatric settings, pure HCM has an estimated incidence of 4.7 per million children. The disease is often sub-clinical and goes unrecognized mainly because most patients with HCM have only mild symptoms, if any. However, sudden cardiac death, the most dramatic clinical occurrence and the primary concern for patients and physicians alike, may be the first manifestation of the disease. We describe a case of compound heterozygosity in the MYBPC3 gene (p.Glu258Lys and IVS25-1G>A) associated with biventricular hypertrophy, atrial enlargement and subsequent neonatal death 33 days postpartum. Other studies have reported compound and/or double heterozygosis in the same or different sarcomeric genes during childhood and adulthood, and neonatal presentations have also been described. Our observations show that the combination of a missense (p.Glu258Lys) and a splice-site mutation (IVS25-1G>A) profoundly affects the clinical course. In families in which parental mutations are known, preimplantation (where ethically and legally feasible) or prenatal genetic screening should be adopted because: (1) neonatal HCM in genetic heterozygosity is potentially lethal and (2) heart disease is the most common developmental malformation and the leading cause of neonatal mortality and morbidity. 相似文献
142.
Martina Gáliková Peter Klepsatel Gabriele Senti Thomas Flatt 《Experimental gerontology》2011,46(2-3):141-147
In the last two decades it has become clear that hormones and gene mutations in endocrine signaling pathways can exert major effects on lifespan and related life history traits in worms, flies, mice, and other organisms. While most of this research has focused on insulin/insulin-like growth factor-1 signaling, a peptide hormone pathway, recent work has shown that also lipophilic hormones play an important role in modulating lifespan and other life history traits. Here we review how steroid hormones, a particular group of lipophilic hormones, affect life history traits in the nematode worm (Caenorhabditis elegans) and the fruit fly (Drosophila melanogaster), with a particular focus on longevity. Interestingly, a comparison suggests that parallel endocrine principles might be at work in worms and flies in these species and that steroid hormones interact with the gonad to affect lifespan. 相似文献
143.
Gabriele Menzinger 《Wiener Medizinische Wochenschrift》2016,166(9-10):275-277
144.
145.
146.
Endocrine mucin‐producing sweat gland carcinoma: Clinicopathologic,immunohistochemical, and molecular analysis of 11 cases with emphasis on MYB immunoexpression
下载免费PDF全文
![点击此处可从《Journal of cutaneous pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
147.
Miriam Nannette Ebert Gabriele Beyer-Sehlmeyer Ute Monika Liegibel Tanja Kautenburger Thomas Walter Becker Beatrice Louise Pool-Zobel 《Nutrition and cancer》2013,65(1-2):156-164
Butyrate, one of the major products of gut fermentation, is known to inhibit proliferation, induce apoptosis and differentiation, and increase phase II enzyme activities in tumor cells, whereas little information is available on protective effects in less-transformed colon cells. The aim of this study was to investigate whether the chemoprotective mechanism of glutathione S-transferase (GST) induction by butyrate could also play a role in earlier stages of colon carcinogenesis and whether chemoresistance of cells toward the endogenous genotoxic risk factor 4-hydroxy-2-nonenal (HNE) could be a consequence of butyrate treatment. As cell models, we used the human tumor cell lines HT29 and HT29 clone 19A, a differentiated subclone with properties resembling primary colon cells. We determined the expression of GSTP1 protein (enzyme-linked immunosorbent assay), the major GST in HT29, GSTP1 mRNA (Northern blotting), GST activity, intracellular glutathione, and total protein. The genotoxic impact of HNE (100-200 μM) was compared in butyrate-treated and nontreated cells using single-cell microgel electrophoresis. Our results show that GSTP1 mRNA, GSTP1 protein, GST activity, and total protein were increased (1.2- to 2.5-fold) and glutathione levels were maintained after 24- 72 h of incubation with 4 mM butyrate. Moreover, a marked reduction of HNE-induced genotoxicity was caused by preincubation with butyrate. Butyrate also induced the phosphorylation of extracellular signal-regulated kinases (ERK1/2, Western blotting) after 5-30 min, which indicates a regulation of GST expression by this signal pathway. Most effects were greater in HT29 parent cells than in clone cells. In conclusion, butyrate enhances expression of GST and other proteins in both cell lines, which leads to an enhanced chemoprotection, reducing the impact of HNE genotoxicity. Thus butyrate could play a role in early and later stages of cancer prevention by reducing exposure to relevant risk factors. 相似文献
148.
Ilaria Franzese MD Alessandra Francica MD Gabriele Pesarini MD Leonardo Gottin MD Flavio L. Ribichini MD Francesco Onorati MD PhD Giuseppe Faggian MD 《Journal of cardiac surgery》2020,35(8):2093-2096
Balloon rupture is an uncommon complication during balloon-expandable transcatheter aortic valve replacement (TAVR). We describe a balloon rupture and tearing with intraventricular entrapment complicating transapical-TAVR, as well as our bailout retrieval of the failed device. 相似文献
149.
Buyun Liu Yangbo Sun Guifeng Xu Linda G. Snetselaar Gabriele Ludewig Robert B. Wallace Wei Bao 《Journal of the Academy of Nutrition and Dietetics》2019,119(4):617-625