SUMMARY A case of chronic invasive paranasal aspergillosis is described which, despite an initial poor prognosis, responded well to treatment with itraconazole. 相似文献
Many patients with previous poliomyelitis develop 'post-polio syndrome'
(PPS) in which late functional deterioration follows a period of relative
stability. The frequency with which PPS can be attributed to clearly
defined causes remains uncertain. We reviewed 283 newly- referred patients
with previous poliomyelitis seen consecutively over a 4-year period; 239
patients developed symptoms of functional deterioration at a mean of 35
(5-65) years after the paralytic illness. Functional deterioration was
associated with orthopaedic disorders in 170 cases, neurological disorders
in 35, respiratory disorders in 19 and other disorders in 15. Progressive
post-polio muscular atrophy was not observed. Functional deterioration
following paralytic polio- myelitis is common, and associated with
orthopaedic, neurological, respiratory and general medical factors which
are potentially treatable.
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Objective. To evaluate the effect of strain rate (ġ3), apparent density (a) and tissue density (t) on Young's modulus (E), strength (σu) and ultimate strain (u) on intervertebral bone from a Chinese population.
Methods. Testing was performed by uniaxial compression at five strain rates on 36 human trabecular bone specimens from three male T12˜L4 vertebrae.
Results. Apparent density ranged between 0.46 and 0.71 g/cm3. Tissue density ranged between 1.02 and 1.54 g/cm3. Non-linear regression analyses using strength, Young's modulus or ultimate strain as dependent variables (Y) and strain rate and apparent density or tissue density as independent variables were performed using the following equation: Y = abġ3c. The exponent of apparent density and strain rate to Young's modulus were 1.88 and 0.07, separately (P = 0.0007). The variation of strength was explained only by apparent density with an exponent of 1.29 (P = 0.0107). The variation of Young's modulus was explained equally by the quadratic and cubic relationship to apparent density or tissue density (P < 0.01). Ultimate strain varied independently of apparent density or tissue density and strain rate. 相似文献
BACKGROUND: Hypotensive reactions to platelet transfusions performed with white cell (WBC)-reduction filters with negatively charged surfaces have been reported recently in patients taking angiotensin- converting enzyme (ACE) inhibitors. Experimental studies have shown that the filter material can activate bradykinin, which may cause symptoms in patients with reduced bradykinin catabolism. Symptomatic adverse reactions after the administration of fresh-frozen plasma (FFP) through a WBC-reduction filter have not been reported in a patient on ACE Inhibitor medication. CASE REPORT: A 58-year-old man with congenital coagulation factor V deficiency and hypertension treated with an ACE inhibitor was admitted for rehabilitation after orthopedic surgery. On 3 consecutive days, he received FFP through a WBC-reduction filter; within minutes of the beginning of each infusion, he experienced a drop in blood pressure, facial erythema, abdominal pain, and anxiety. When the infusions were stopped, symptoms quickly abated without treatment. Multiple prior transfusions of unfiltered FFP and FFP filtered through a WBC-reduction filter made by a different manufacturer, as well as subsequent transfusions of unfiltered FFP, had not produced such reactions. CONCLUSION: Facial flushing, hypotension, and abdominal pain after FFP administration in a patient on ACE inhibitor medication appeared to be associated with a specific type of WBC-reduction filter. This association and other reported studies suggest that special caution is warranted when patients who are treated with ACE inhibitors receive blood components administered through WBC- reduction filters capable of generating bradykinin. 相似文献
We determined serum concentrations of neopterin, soluble tumour necrosis
factor (55 kDa) receptor (sTNF-R) and soluble interleukin-2 receptor
(sIL-2R) in plasma of 44 patients with polymyositis (PM)/dermatomyositis
(DM), including 15 patients with primary PM, 13 patients with primary DM,
and 16 patients with myositis and systemic sclerosis in overlap.
Concentrations of neopterin, sTNF-R and sIL-2R were measured using
commercially available immunoassays. Serum neopterin was increased in 35 of
44 PM/DM patients (80%), sTNF-R in 14 (32%) and sIL-2R in 18 (41%)
patients, respectively. There were significant correlations between serum
neopterin and sTNF-R, sIL-2R and erythrocyte sedimentation rate (all P <
0.001). Neopterin, as well as sTNF-R and sIL-2R, did not correlate with
clinical (neuromuscular and activities of daily living scores) and
laboratory (creatine kinase levels) manifestations of myositis. Increased
serum levels of neopterin were associated with non-muscular manifestations
of PM/DM. In conclusion, serum neopterin appears to be a useful laboratory
marker for ongoing immune activation and global disease activity in PM/DM.
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