全文获取类型
收费全文 | 429篇 |
免费 | 27篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 4篇 |
妇产科学 | 6篇 |
基础医学 | 42篇 |
临床医学 | 30篇 |
内科学 | 255篇 |
神经病学 | 14篇 |
特种医学 | 13篇 |
外科学 | 19篇 |
综合类 | 1篇 |
预防医学 | 43篇 |
眼科学 | 5篇 |
药学 | 10篇 |
肿瘤学 | 12篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 6篇 |
2018年 | 5篇 |
2017年 | 4篇 |
2016年 | 9篇 |
2015年 | 8篇 |
2014年 | 8篇 |
2013年 | 9篇 |
2012年 | 24篇 |
2011年 | 30篇 |
2010年 | 11篇 |
2009年 | 15篇 |
2008年 | 23篇 |
2007年 | 29篇 |
2006年 | 18篇 |
2005年 | 22篇 |
2004年 | 26篇 |
2003年 | 25篇 |
2002年 | 32篇 |
2001年 | 35篇 |
2000年 | 21篇 |
1999年 | 19篇 |
1998年 | 6篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 4篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1992年 | 6篇 |
1991年 | 9篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1963年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有456条查询结果,搜索用时 15 毫秒
51.
52.
Neural-tube defects and derangement of homocysteine metabolism 总被引:16,自引:0,他引:16
R P Steegers-Theunissen G H Boers F J Trijbels T K Eskes 《The New England journal of medicine》1991,324(3):199-200
53.
54.
55.
F.M.J. Zuyderhoudt W. Boers C. Linthorst G.G.A. Jörning P. Hengeveld 《Clinica chimica acta; international journal of clinical chemistry》1978,88(1):37-44
To measure human serum ferritin and rat plasma ferritin a non-competitive enzyme-linked immunoassay has been developed using horseradish peroxidase as the enzyme. In this assay it proved necessary to use heated rat plasma to obtain reproducible ferritin values. The heating procedure caused a loss of 38% of the plasma ferritin. Rat plasma ferritin values have been corrected for this loss. The standard deviation, from duplicate normal human and rat samples is 10 ng ferritin/ml serum and 69 ng/ml plasma, respectively. (The mean ferritin concentrations are: in human sera, 82 ng/ml and in rat plasma 762 ng/ml.) Mean recovery of added liver ferritin in the human serum is 104% +/- 4% (+/-S.E.M') and in the rat plasma 101% +/- 3% (+/- S.E.M.). Normal ferritin concentrations varied in the human material between 30 ng/ml and 300 ng/ml serum, and in the rat plasma between 500 ng/ml and 1300 ng/ml. During increased body iron and acute hepatitis the ferritin concentrations, in patients as well as in rats, exceeded the upper limit of the normal values in most cases. During human hepatitis high serum ferritin levels combined with high serum iron levels were measured. The high serum iron concentrations could not be explained by the high serum ferritin concentrations, even if the iron content of the ferritin is supposed to be high. 相似文献
56.
MCID/Low Disease Activity State Workshop: summary,recommendations, and research agenda 总被引:2,自引:0,他引:2
Wells G Anderson J Boers M Felson D Heiberg T Hewlett S Johnson K Kirwan J Lassere M Robinson V Shea B Simon L Strand V van Riel P Tugwell P 《The Journal of rheumatology》2003,30(5):1115-1118
The OMERACT 6 Minimal Clinically Important Difference/Low Disease Activity Workshop was organized with the aim of meeting the many challenges that exist in determining a low disease activity in rheumatoid arthritis (RA). This article presents an overview of that workshop, including results of the voting, a summary of associated discussions, recommendations, and a proposed research agenda. 相似文献
57.
In a second update of a systematic review, many new developments in the
combined drug treatment of rheumatoid arthritis (RA) are highlighted. In
early RA patients, step-down bridge therapy that includes corticosteroids
leads to much enhanced efficacy at acceptable or low toxicity. The effects
on joint damage may be persistent, but the symptomatic effects are probably
dependent on continued corticosteroid dosing. In late patients, cyclosporin
improves a suboptimal clinical response to methotrexate, and the triple
combination of methotrexate, sulphasalazine and hydroxychloroquine appears
to be clinically better than the components. Other combinations are either
untested, tested at low sample size, or show negative interaction. In view
of the low volume of evidence, most studies need confirmation by
replication.
相似文献
58.
Rheumatoid factor measured by fluoroimmunoassay: a responsive measure of rheumatoid arthritis disease activity that is associated with joint damage 下载免费PDF全文
Knijff-Dutmer E Drossaers-Bakker W Verhoeven A van der Sluijs Veer G Boers M van der Linden S van de Laar M 《Annals of the rheumatic diseases》2002,61(7):603-607
OBJECTIVES: To determine whether rheumatoid factors (RFs), measured as continuous variables by time resolved fluoroimmunoassay, reflect disease activity in rheumatoid arthritis (RA). Further, to study the association of RFs and other disease activity parameters with radiological joint damage, especially in individual patients. METHODS: In active, early RA, IgM and IgA RFs, as well as erythrocyte sedimentation rate (ESR), C reactive protein (CRP), tender joint score, and swollen joint score were assessed regularly. At the study start and at 56 and 80 weeks, radiographs of hands and feet were assessed by the Sharp score (van der Heijde modification). Associations between RFs and disease activity parameters were studied. In addition, associations between radiographic damage and disease activity parameters (baseline and time integrated) were analysed by non-parametric tests and multiple regression analysis. The relation between time integrated disease activity parameters and radiological damage in individual patients was analysed and visualised. RESULTS: 155 patients were included. RF levels were strongly associated with the disease activity parameters (especially ESR and CRP) and with each other. All disease activity parameters, at baseline as well as time integrated parameters, were associated with (the progression of) radiographic damage. Moreover, in individual patients, a linear relationship between time integrated disease activity parameters and progression of radiological damage was seen. CONCLUSION: RFs, measured as continuous variables, can be considered as disease activity parameters in patients with RA. The level of RF at baseline and the exposure to RF over time is associated with radiological damage. In individual patients, there is a constant relation between disease activity and radiological damage. 相似文献
59.
Alternative Ways to Quantify Sustained Remission: Applying the Continuity Rewarded Score and Patient Vector Graph 下载免费PDF全文
60.
Landewé R Geusens P Boers M van der Heijde D Lems W te Koppele J van der Linden S Garnero P 《Arthritis and rheumatism》2004,50(5):1390-1399
OBJECTIVE: To investigate in a randomized clinical trial setting with an aggressive combination-therapy arm and a mild-monotherapy arm, whether therapy-induced changes in urinary C-terminal crosslinking telopeptide of type I collagen (CTX-I) and type II collagen (CTX-II) predict 5-year radiographic progression in patients with rheumatoid arthritis (RA). METHODS: Patients had participated in the COBRA (Combinatietherapie Bij Reumato?de Artritis) trial comparing aggressive step-down combination therapy (the COBRA regimen, including temporary high-dose prednisolone, temporary low-dose methotrexate, and sulfasalazine [SSZ]) and mild monotherapy (SSZ). Urinary CTX-I and CTX-II levels were measured at baseline and 3, 6, 9, and 12 months after initiation of treatment. Radiographs were scored according to the modified Sharp/van der Heijde method (mean of 2 independent readers who were aware of the sequence). Individual long-term radiographic progression was estimated, using baseline radiographs and all radiographs obtained during the followup period, by simple linear regression analysis (curve fitting). RESULTS: Both COBRA therapy and SSZ monotherapy produced a significant decrease in urinary CTX-I and CTX-II levels at 3 months, and this decrease was amplified at 6 months. COBRA therapy suppressed CTX-II (change from baseline levels -36% and -43% at 3 and 6 months, respectively), but not CTX-I, significantly better than did SSZ (-17% and -21% at 3 and 6 months, respectively) at 3 and 6 months. The magnitude of the decrease in urinary CTX-II levels at 3 months significantly predicted long-term (5-year) radiographic progression (beta = 0.48 [95% confidence interval (95% CI) 0.13, 0.83]). This effect was independent of the change in disease activity and inflammation indices at 3 months. Patients whose CTX-II levels were normalized (<150 ng/mmoles of urinary creatinine) at 3 months had a significantly higher chance of radiographic stability (no progression over 5 years) than did patients whose CTX-II levels were increased both at baseline and at 3 months (odds ratio 4.5 [95% CI 1.5, 13]). CONCLUSION: The individual CTX-II response measured after 3 months of therapy in patients with active RA who had increased CTX-II levels at baseline independently predicts long-term radiographic progression. Urinary CTX-II levels may be used as early markers of treatment efficacy in patients with RA. 相似文献