全文获取类型
收费全文 | 1977489篇 |
免费 | 140800篇 |
国内免费 | 3998篇 |
专业分类
耳鼻咽喉 | 28510篇 |
儿科学 | 64893篇 |
妇产科学 | 57570篇 |
基础医学 | 286000篇 |
口腔科学 | 55568篇 |
临床医学 | 168037篇 |
内科学 | 388502篇 |
皮肤病学 | 41710篇 |
神经病学 | 155070篇 |
特种医学 | 77972篇 |
外国民族医学 | 672篇 |
外科学 | 307767篇 |
综合类 | 42247篇 |
现状与发展 | 1篇 |
一般理论 | 532篇 |
预防医学 | 145621篇 |
眼科学 | 45708篇 |
药学 | 147374篇 |
1篇 | |
中国医学 | 3887篇 |
肿瘤学 | 104645篇 |
出版年
2018年 | 18925篇 |
2016年 | 16113篇 |
2015年 | 18452篇 |
2014年 | 25996篇 |
2013年 | 39745篇 |
2012年 | 53922篇 |
2011年 | 57773篇 |
2010年 | 34584篇 |
2009年 | 32671篇 |
2008年 | 55602篇 |
2007年 | 59794篇 |
2006年 | 60690篇 |
2005年 | 59452篇 |
2004年 | 57100篇 |
2003年 | 55422篇 |
2002年 | 54546篇 |
2001年 | 88123篇 |
2000年 | 90553篇 |
1999年 | 77359篇 |
1998年 | 21930篇 |
1997年 | 19821篇 |
1996年 | 19951篇 |
1995年 | 18726篇 |
1994年 | 17818篇 |
1993年 | 16648篇 |
1992年 | 61879篇 |
1991年 | 60484篇 |
1990年 | 59467篇 |
1989年 | 57546篇 |
1988年 | 53738篇 |
1987年 | 52711篇 |
1986年 | 50437篇 |
1985年 | 48159篇 |
1984年 | 36083篇 |
1983年 | 31104篇 |
1982年 | 18681篇 |
1981年 | 16431篇 |
1979年 | 34061篇 |
1978年 | 23953篇 |
1977年 | 20527篇 |
1976年 | 19433篇 |
1975年 | 21368篇 |
1974年 | 25273篇 |
1973年 | 24306篇 |
1972年 | 23131篇 |
1971年 | 21519篇 |
1970年 | 20253篇 |
1969年 | 19219篇 |
1968年 | 18235篇 |
1967年 | 16295篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
F. Ide K. Obara K. Enatsu K. Mishima I. Saito 《Journal of oral pathology & medicine》2005,34(3):187-189
Sclerosing mucoepidermoid carcinoma (SMEC) with eosinophilia is a rare but distinctive tumor usually affecting the thyroid. SMEC involvement of salivary gland is exceptional, with only six cases in the literature. We present here the first case of an intermediate-grade SMEC, arising from the intraoral minor salivary glands. A particularly interesting finding is the cytoplasmic accumulation of eosinophilic hyaline granules in carcinoma cells, similar to aberrant zymogen-like granules previously described in salivary sclerosing polycystic adenosis. 相似文献
993.
994.
A. Sh. Oganisyan A. S. Noravyan I. A. Dzhagatspanyan I. M. Nazaryan A. G. Akopyan 《Pharmaceutical Chemistry Journal》2007,41(11):588-590
New methods for the synthesis of 4-substituted 6,7-dihydro-7,7-dimethyl-5-oxo-9H-pyrano-[4′,3′: 4,5]-thieno[3,2-e]imidazo[1,2-a]pyrimidines
and their hydrochlorides are developed. The anticonvulsant and tranquilizer properties of newly synthesized compounds have
been studied.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 11, pp. 22–24, November, 2007. 相似文献
995.
Autophagy-mediated chemosensitizing effect of the plant alkaloid voacamine on multidrug resistant cells. 总被引:1,自引:0,他引:1
S Meschini M Condello M Marra G Formisano E Federici G Arancia 《Toxicology in vitro》2007,21(2):197-203
In our previous studies, voacamine, a bisindolic alkaloid extracted from Peschiera fuchsiaefolia, was examined for its possible capability of enhancing the cytotoxic effect of doxorubicin (DOX) on multidrug resistant (MDR) human osteosarcoma cells (U-2 OS-R). Voacamine induced in resistant cells a significant increase of drug retention and intranuclear location which became comparable to those observed in the parental sensitive counterparts (U-2 OS-WT). In the present study, the cell survival analysis and the electron microscopic observations confirmed the evident cytotoxicity of DOX on MDR cells after pre-treatment with the plant extract. Moreover, an increase of the reactivity of P-glycoprotein (P-gp) with the monoclonal antibody UIC2, which recognizes an epitope of the drug transporter in its functional conformation, was revealed, demonstrating that voacamine is a substrate of P-gp, thus acting as a competitive antagonist of the cytotoxic agent. Moreover, to investigate if the enhancement of the cytotoxic effect induced by voacamine could be due to an apoptotic process, we carried out the analysis of cell morphology after Hoechst staining and the quantification of apoptosis by Annexin V-FITC assay. These evaluations showed a very low rate of apoptosis in U-2 OS-R cells treated with voacamine and DOX given in association. In addition, the combined treatment induced ultrastructural modifications suggestive of autophagic cell death. In particular, transmission electron microscopy observations revealed the presence of numerous lysosomes and the formation of a large number of autophagosomes containing residual digested material. In conclusion, these findings seem to indicate that voacamine is capable of enhancing the cytotoxic effect of DOX on MDR cells by favouring a lethal autophagic process. 相似文献
996.
997.
T. Pinzer M. Reiß H. Bourquain K. G. Krishnan G. Schackert 《Acta neurochirurgica》2006,148(10):1085-1090
Summary Aspergillosis belongs to the group of mycotic diseases of paranasal sinuses. The invasive forms, and particularly the fulminant
forms, are potentially fatal. Isolated aspergillosis of the sphenoid sinus or the clivus is a difficult diagnosis, since the
often misleading clinical manifestations of this rare disease develop late. These patients become apparent by neurological
signs such as cavernous sinus syndrome, pseudotumor of the pituitary or the orbit. Diagnosis is often made intra-operatively
or on histological examination.
We report a case of invasive aspergillosis uniquely involving the sellar area revealed by clinical features suggesting a pseudotumor
of the pituitary. Although such lesions are almost always seen in immune suppressed subjects, in our case, the patient was
immune competent and had no past history of sinusitis.
The question of whether, and when to perform limited or extensive surgery remains an issue for discussion, owing to the rarity
of this disease honed by lack of experience. It depends on several factors: the kind of disease, the immunity, the subtype
of invasive fungal sinusitis and the degree of tissue invasion. 相似文献
998.
999.
Inflammation Research - . 相似文献
1000.
M. M. Marchenko G. P. Kopyl’chuk I. A. Shmarakov O. V. Ketsa V. N. Kushnir 《Pharmaceutical Chemistry Journal》2006,40(6):296-297
The antitumor activity of 5-(5′,6′-benzocoumaro-3′-yl)methylaminouracil (BCMU) and its liposomal medicinal form was studied
in comparison to 5-fluorouracil (5-FU), a well-known antitumor drug widely used in oncological practice. The half-lethal dose
of BCMU is 14.8 ± 4.2 mg/kg, while the optimum effective dose of the drug is 6 mg/kg. In this dose, BCMU combines low toxicity
with significant antitumor activity, which is manifested by increased tumor growth inhibition (TGI) at a 19% increase in the
lifetime (LT) of experimental animals. The antitumor activity of the liposomal form of BCMU is quantitatively and qualitatively
superior to that of the nonmodified compound and 5-FU, which is manifested by the most pronounced TGI value and by a significant
LT increase.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 6, pp. 6–7, June, 2006. 相似文献