首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1470030篇
  免费   103872篇
  国内免费   2338篇
耳鼻咽喉   20745篇
儿科学   48294篇
妇产科学   41737篇
基础医学   214993篇
口腔科学   40055篇
临床医学   123761篇
内科学   293963篇
皮肤病学   31719篇
神经病学   116944篇
特种医学   55840篇
外国民族医学   457篇
外科学   221660篇
综合类   27324篇
现状与发展   1篇
一般理论   358篇
预防医学   110536篇
眼科学   33038篇
药学   111491篇
  1篇
中国医学   3086篇
肿瘤学   80237篇
  2019年   11427篇
  2018年   18316篇
  2017年   13191篇
  2016年   14320篇
  2015年   16352篇
  2014年   20921篇
  2013年   32311篇
  2012年   47547篇
  2011年   49864篇
  2010年   28094篇
  2009年   25110篇
  2008年   46892篇
  2007年   50698篇
  2006年   50163篇
  2005年   49326篇
  2004年   47091篇
  2003年   45157篇
  2002年   44124篇
  2001年   62580篇
  2000年   64143篇
  1999年   54700篇
  1998年   14944篇
  1997年   13402篇
  1996年   13607篇
  1995年   12846篇
  1994年   12198篇
  1992年   43328篇
  1991年   42463篇
  1990年   41916篇
  1989年   40529篇
  1988年   37815篇
  1987年   36899篇
  1986年   35179篇
  1985年   33481篇
  1984年   24917篇
  1983年   21673篇
  1982年   12895篇
  1981年   11342篇
  1979年   23531篇
  1978年   16489篇
  1977年   14293篇
  1976年   13462篇
  1975年   14807篇
  1974年   17412篇
  1973年   16837篇
  1972年   16004篇
  1971年   14921篇
  1970年   13876篇
  1969年   13421篇
  1968年   12566篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.

Background

Arterial vascular anomalies in patients undergoing kidney transplantation (KT) are correlated with a higher incidence of early surgical complications, potentially causing graft loss. Arterial reconstruction allows patients to overcome these surgical challenges, thus minimizing the risk of poor outcomes. The aim of the present study is to retrospectively investigate the safety and effectiveness of the multiple arterial reconstruction technique with a Teflon patch in case of an unavailable aortic patch: to do so, surgical complications, graft function, and patient survival were evaluated.

Methods

During the period January 2009 to August 2016, 202 adult deceased-donor KTs were performed at our center. Group A (n = 27; reconstruction of multiple arteries) and Group B (n = 175; control group) were compared.

Results

No differences were observed between the 2 groups in terms of early postoperative course, with no vascular complication observed in Group A. No vascular patch infections were reported, nor longer cold ischemia time rates. Similarly, long-term survival rates were similar between the 2 groups.

Conclusions

The Teflon-patch arterial reconstruction technique appears to be safe and effective, with an acceptable balance of benefits and potential risks of using a prosthetic material. Studies based on larger series are needed to further validate this approach.  相似文献   
82.

Background

Since recent reports have shown that (-)-Epigallocatechin-3-gallate (EGCG) could be used for treating proliferative and inflammatory disorders, we explored its use for the management of corneal chemical burns.

Materials and methods

Initially, EGCG was assayed on the rabbit corneal epithelial cell line RCE1(5T5) to establish the best testing conditions, and to avoid unwanted outcomes in the experimental animals. Then, we studied its effects on cell proliferation, cell cycle progression and cell differentiation. Afterwards, we instilled EGCG in experimental grade II corneal alkali burns in mice, three times a day up to 21 days, and evaluated by slit lamp examination and histological sections of corneal epithelial, corneal endothelial and stromal edema, as well as the presence of inflammatory cells and neovascularization.

Results

EGCG reduced cell growth and led to a decline in the proportion of proliferative cells in a concentration dependent manner. At 10 μM, EGCG promoted cell differentiation, an effect not related with apoptosis or cytotoxicity. When 10 μM EGCG was instilled in corneal alkali burns in mice three times a day up to 21 days, EGCG significantly reduced corneal opacity and neovascularization. The improved clinical appearance of the cornea was associated to a controlled epithelial growth; epithelial morphology was similar to that observed in normal epithelium and contrasted with the hyperproliferative, desquamating epithelium observed in control burn wounds. EGCG reduced corneal, stromal and endothelial edema, and wound inflammation.

Conclusion

This work constitutes the first evidence for the use of EGCG in the acute phase of a corneal alkali burn, representing a possible novel alternative to improve patient outcomes as an add-on therapy.  相似文献   
83.
84.
85.
86.
87.
88.
89.
BackgroundThe aim of this paper is to assess the current state of quality and outcomes measures being reported for hepatic resections in the recent literature.MethodsMedline and PubMed databases were searched for English language articles published between 1 January 2002 and 30 April 2013. Two examiners reviewed each article and relevant citations for appropriateness of inclusion, which excluded papers of liver donor hepatic resections, repeat hepatectomies or meta-analyses. Data were extracted and summarized by two examiners for analysis.ResultsFifty-five studies were identified with suitable reporting to assess peri-operative mortality in hepatic resections. In only 35% (19/55) of the studies was the follow-up time explicitly stated, and in 47% (26/55) of studies peri-operative mortality was limited to in-hospital or 30 days. The time period in which complications were captured was not explicitly stated in 19 out of 28 studies. The remaining studies only captured complications within 30 days of the index operation (8/28). There was a paucity of quality literature addressing truly patient-centred outcomes.ConclusionQuality outcomes after a hepatic resection are inconsistently reported in the literature. Quality outcome studies for a hepatectomy should report mortality and morbidity at a minimum of 90 days after surgery.  相似文献   
90.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号