全文获取类型
收费全文 | 2718篇 |
免费 | 133篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 37篇 |
妇产科学 | 26篇 |
基础医学 | 391篇 |
口腔科学 | 67篇 |
临床医学 | 148篇 |
内科学 | 804篇 |
皮肤病学 | 30篇 |
神经病学 | 332篇 |
特种医学 | 65篇 |
外科学 | 322篇 |
综合类 | 6篇 |
预防医学 | 49篇 |
眼科学 | 26篇 |
药学 | 281篇 |
中国医学 | 5篇 |
肿瘤学 | 243篇 |
出版年
2023年 | 14篇 |
2022年 | 27篇 |
2021年 | 57篇 |
2020年 | 37篇 |
2019年 | 42篇 |
2018年 | 57篇 |
2017年 | 32篇 |
2016年 | 37篇 |
2015年 | 52篇 |
2014年 | 63篇 |
2013年 | 67篇 |
2012年 | 140篇 |
2011年 | 127篇 |
2010年 | 76篇 |
2009年 | 56篇 |
2008年 | 108篇 |
2007年 | 120篇 |
2006年 | 114篇 |
2005年 | 122篇 |
2004年 | 108篇 |
2003年 | 115篇 |
2002年 | 115篇 |
2001年 | 75篇 |
2000年 | 103篇 |
1999年 | 88篇 |
1998年 | 26篇 |
1997年 | 21篇 |
1996年 | 15篇 |
1995年 | 14篇 |
1994年 | 25篇 |
1993年 | 19篇 |
1992年 | 91篇 |
1991年 | 59篇 |
1990年 | 73篇 |
1989年 | 63篇 |
1988年 | 57篇 |
1987年 | 65篇 |
1986年 | 60篇 |
1985年 | 44篇 |
1984年 | 31篇 |
1983年 | 31篇 |
1982年 | 28篇 |
1981年 | 18篇 |
1979年 | 18篇 |
1978年 | 12篇 |
1974年 | 11篇 |
1973年 | 19篇 |
1972年 | 11篇 |
1968年 | 13篇 |
1967年 | 13篇 |
排序方式: 共有2860条查询结果,搜索用时 0 毫秒
41.
Charlotte V. Hobbs Jan Drobeniuc Theresa Kittle John Williams Paul Byers Panayampalli S. Satheshkumar Kengo Inagaki Meagan Stephenson Sara S. Kim Manish M. Patel Brendan Flannery CDC COVID- Response Team CDC COVID- Response Team Bailey Alston Shanna J. Bolcen Darbi Boulay Peter Browning Li Cronin Ebenezer David Tonya Hayden Han Li Travis Lim Panagiotis Maniatis Palak Patel Mathew Pauly Amanda Poe Lili Punkova Vera Semenova Evelene P. Steward-Clark Alexandra Tejada Briana Zellner 《MMWR. Morbidity and mortality weekly report》2021,70(9):312
42.
Rabia Faridi Rizwan Yousaf Shoujun Gu Sayaka Inagaki Amy E. Turriff Keith Pelstring Bin Guan Amelia Naik Andrew J. Griffith Samuel Mawuli Adadey Elvis Twumasi Aboagye Gordon A. Awandare Robert J. Morell Ekaterini Tsilou Amanda G. Noyes Laura A. G. Sulmonte Ambroise Wonkam Isabelle Schrauwen Suzanne M. Leal Hela Azaiez Carmen C. Brewer Sheikh Riazuddin Robert B. Hufnagel Michael Hoa Wadih M. Zein J. Karl de Dios Thomas B. Friedman 《Clinical genetics》2023,103(6):699-703
43.
Iwase K Kato K Ohtani S Tsujimura T Hanai T Inagaki A Jimbo S Kobayashi N Yamamoto H Nagasaka A Miura K 《Breast cancer (Tokyo, Japan)》1997,4(3):155-160
The localization of Cu/Zn- and Mn-superoxide dismutase (SOD) in breast cancer tissue (12 papillotubular carcinomas, 21 solid-tubular carcinomas, 16 scirrhous carcinomas, 1 medullary carcinoma, 1 secreting carcinoma, 1 lobular carcinoma, 1 Paget's disease) was investigated via an immunohistochemical technique using antihuman Cu/Zn- and Mn-SOD antibodies in 10%formalin fixed-paraffin embedded thin sections. Both SODs stained strongly in the normal breast gland, but not clearly in many cancer tissues. Furthermore, Cu/Zn-SOD stained more strongly in well differentiated tubular carcinomas than in poorly differentiated tubular carcinomas. It tended to stain less in tumors which recurred or had a poor outcome, and in tumors with a diploid pattern on DNA flow cytometry. Mn-SOD staining was similar to that of Cu/Zn-SOD, but no significant differences among subgroups was found, since the incidence of positively staining tumors was too small in all groups. The intensity of SOD staining seems to change in relation to cell proliferation and differentiation in breast carcinoma, and may be a prognostic indicator, since SOD decreased in poorly differentiated carcinoma and in tumors which developed distant metastasis. Thus, the localization of SOD in breast cancer tissue can provide useful information for cancer treatment. 相似文献
44.
Inagaki M Yabuki H Hashimoto M Maguchi M Kino S Sawa M Ojima H Tokusashi Y Miyokawa N Kusano M Kasai S 《Surgery today》1999,29(12):1260-1263
We describe herein the case of a 51-year-old woman in whom metastatic tumor seeding of the percutaneous transhepatic biliary
drainage tract occurred following a pancreatoduodenectomy for carcinoma of the distal common bile, duct. An abdominal computed
tomography scan done 6 months after the initial operation detected a hepatic lesion located at the site of the previous percutaneous
transhepatic biliary drainage tract. Implantation of bile duct carcinoma in the drainage tract was diagnosed, and the recurrent
tumor was successfully resected by performing a subsegmentectomy of segment 3 and removal of the adjacent abdominal wall.
At present, 5 years and 4 months after the second resection, the patient is in good health without any signs of recurrence.
This case report demonstrates that an aggressive surgical approach should be performed for tumor seeding of a transhepatic
biliary catheter tract. 相似文献
45.
T Taniguchi R Inagaki S Murata I Akiba I Muramatsu 《British journal of pharmacology》1999,127(4):962-968
1. The human recombinant alpha1a-adrenoceptor (AR) has been stably expressed in Chinese hamster ovary cells. Four stable clones, aH4, aH5, aH6 and aH7, expressing 30, 370, 940 and 2900 fmol AR mg(-1) protein, respectively, have been employed to characterize this AR subtype using radioligand binding and microphysiometry to measure extracellular acidification rates. 2. Noradrenaline (NA) gave concentration-dependent responses in microphysiometry with increasing extracellular acidification rates. The potency of NA increased as the receptor density increased; pEC50 values of NA for the clones aH4, aH5, aH6 and aH7 were 6.9, 7.5, 7.8 and 8.1, respectively. This increase of potency according to receptor density indicates the presence of spare receptor for NA. Methoxamine, phenylephrine, oxymetazoline and clonidine also gave concentration-dependent responses with various intrinsic activities. 3. Antagonists shifted concentration-response curves for NA rightward in a concentration-dependent manner. Schild analysis revealed that the affinity profile of this AR subtype to antagonists in the clone aH7 had a typical pattern for the alpha1a-AR; high affinity for prazosin and WB 4101, and low affinity for BMY7378 (pA2=9.5, 9.8 and 7.3, respectively). This profile is similar in the case of the clone aH4. These affinities were in good agreement with those obtained in binding experiments. 4. These results have demonstrated that (1) classical receptor theory can be applied in microphysiometry, and (2) microphysiometry is a useful tool to investigate the pharmacological characterization of alpha1a-AR. 相似文献
46.
In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla
Kim NY Pae HO Ko YS Yoo JC Choi BM Jun CD Chung HT Inagaki M Higuchi R Kim YC 《Planta medica》1999,65(7):656-658
Bioassay-guided fractionation of an H2O extract of the barks of Fraxinus rhynchophylla has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, ferulaldehyde (1) and scopoletin (3) together with a coumarin, fraxidin (2). Compounds 1 and 3 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner by murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was reflected in the decreased amount of iNOS protein, as determined by Western blotting. 相似文献
47.
Yoshimi Inagaki Chikara Tashiro Yoshihiro Miwa Ikuto Yoshiya 《Journal of anesthesia》1996,10(2):99-104
To investigate the effects of four volatile anesthetics (halothane, enflurane, isoflurane, and sevoflurane) on postanesthetic
ventilation and levels of consciousness, we enrolled 24 patients undergoing tympanoplasty in this study. Anesthesia was maintained
with 67% nitrous oxide and one of four volatile anesthetics. We measured end-tidal carbon dioxide concentration (CETco2), minute volume (
) and respiratory rate (RR), and determined the volatile anesthetic concentration in whole arterial blood (CBAnesth) and arterial carbon dioxide tension (Paco2) at 20 min and 2h after tracheal extubation. We also observed the level of consciousness (awake, drowsy, and asleep) before
the measurement. Ventilatory variables were similar among the four groups at 20 min, although the ratio of volatile anesthetic
concentration in the alveoli to the minimum alveolar concentration (MAC) (CAAnesth/MAC ratio) calculated from CBAnesth in the halothane group was twice those in the other groups. In the halothane group, Paco2 was significantly higher, and
and RR were significantly lower compared with the isoflurane and sevoflurane groups at 2h. Halothane tended to prolong the
recovery of levels of consciousness. We conclude that isoflurane and sevoflurane provide clinical advantages over halothane
on postanesthetic ventilation and recovery of levels of consciousness. 相似文献
48.
T. Mochizuki A. Yamatodani K. Okakura M. Takemura N. Inagaki H. Wada 《Naunyn-Schmiedeberg's archives of pharmacology》1991,343(2):190-195
Summary Using an in vivo intracerebral microdialysis method coupled with an HPLC-fluorometric method, we investigated the extracellular level of endogenous histamine in the anterior hypothalamic area of urethaneanaesthetized rats. The basal rate of release of endogenous histamine in the anterior hypothalamic area measured by this method was 0.09 + 0.01 pmol/20 min. When the anterior hypothalamic area was depolarized by infusion of 100 mM K+ through the dialysis membrane or electrical stimulation at 200 A was applied through an electrode implanted into the ipsilateral tuberomammillary nucleus, histamine release increased to 175% and 188%, respectively, of the basal level. These increases were completely suppressed by removal of extracellular Ca2+. The basal release of histamine was also suppressed after infusion of 10–6 M tetrodotoxin or i.p. administration of 100 mg/kg of -fluoromethylhistidine. On the other hand, 3-fold increase in the basal release was observed after i. p. administration of 5 mg/kg thioperamide. These results clearly indicate that both the basal and evoked release of histamine measured by our method are of neuronal origin.
Send offprint requests to T. Mochizuki at the above address 相似文献
49.
Seno H Ishino H Inagaki T Yamamori C Miyaoaka T 《Dementia and geriatric cognitive disorders》2000,11(3):161-165
We evaluated the activity of daily living (ADL) scores, the frequency of hypertension (HT) and diabetes mellitus (DM), and the frequency and distribution of white matter lesions in a vascular dementia group with multiple lacunar infarctions (VD group; 20 cases) and a nondemented group with multiple lacunar infarctions (non-D group; 32 cases), relative to a normal control group (29 cases). There were no significant differences in HT and DM among the three groups. ADL scores were significantly lower in the VD than in the non-D group, each of which was lower than in the control group. Frequency of white matter lesions (Binswanger's disease-like lesions in the frontal and parietal lobes) was significantly higher in the VD than in the non-D group, which was higher than in the control group. We believe that for dementia with multiple lacunar infarctions, diffusely affected cerebrum including white matter lesions, which results in low ADL scores for symptoms, may be a prerequisite. 相似文献
50.
Takeyuki Yatsu Masanao Sanagi Akira Fujimori Yuichi Tomura Kazumi Hayashi Masayuki Tanahashi Osamu Inagaki 《Pharmacological research》2003,47(3):243-252
Several factors such as proteinuria and renal fibrosis may be important in the progression of many forms of chronic renal diseases. The purposes of the current study were to investigate the progressive renal failure of the rats with surgical renal mass reduction (RMR) and the effect of the angiotensin-converting enzyme (ACE) inhibitor, lisinopril, and to document correlation of several factors associated with progressive renal failure. Rats were subtotal (5/6) nephrectomized by resection of the renal poles and sham-operated. The functional, histological and haematological changes of the rats were studied for up to 10 weeks. After 2 weeks of RMR, oral administration of lisinopril (10 mg kg(-1) per day) was performed for 8 weeks. RMR resulted in progressive renal failure with proteinuria, monocyte/macrophage (ED1+) infiltration, anaemia as assessed by haemoglobin and haematocrit (Htc), renal hypertrophy as assessed by left kidney to body weight ratio (BKW/BW), and renal fibrosis as assessed by glomerular lesions and tubulointerstitial changes. Lisinopril exhibited renoprotection with antiproteinuric effect and inhibition of monocyte/macrophage (ED1+) infiltration. However, beneficial effect of lisinopril on anaemia was not observed. At 10 weeks after surgery, severity of proteinuria positively correlated with plasma creatinine (Pcr), BKW/BW, histological damage, and systolic blood pressure, and negatively correlated with haemoglobin. Severity of tubulointerstitial changes positively correlated with Pcr and blood urea nitrogen, and negatively correlated with haemoglobin and Htc. Moreover, monocyte/macrophage (ED1+) infiltration positively correlated with severity of proteinuria and tubulointerstitial changes. These findings strongly support that proteinuria, monocyte/macrophage infiltration and renal fibrosis appear to play principal roles in the progressive renal failure with anaemia and renoprotection of ACE inhibition may be mediated by multiple actions of ACE inhibitor. The present study confirms that rats with RMR is useful to explore target molecules for renoprotective drugs and evaluate renoprotective effect of new molecular entities. 相似文献