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91.
Beesdo-Baum Katja Knappe Susanne Einsle Franziska Knothe Lisa Wieder Gesine Venz John Rummel-Kluge Christine Heinz Ines Koburger Nicole Schouler-Ocak Meryam Wilbertz Theresia Unger Hans-Peter Walter Ulrich Hein Joachim Hegerl Ulrich Lieb Roselind Pfennig Andrea Schmitt Jochen Hoyer Jürgen Wittchen Hans-Ulrich Bergmann Antje 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2018,61(1):52-64
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Hausärzte sind als Primärversorger für Patienten mit depressiven Störungen entscheidende Weichensteller... 相似文献
92.
Lev Gorfinkel Franziska Wachter Hong-yuan Luo Eileen Hansbury David A. Williams Archana Agarwal David H. K. Chui Alan B. Cantor 《Pediatric blood & cancer》2023,70(1):e30067
Unstable gamma globin variants can cause transient neonatal hemolytic anemia. We have identified a novel variant in a newborn who presented with jaundice and anemia requiring phototherapy and red blood cell transfusion. The patient was found to be heterozygous for the mutation HGB2:c.290T>C, p.Leu97Pro, which we have termed hemoglobin (Hb) Wareham. This substitution is expected to generate an unstable hemoglobin with increased oxygen affinity based on the homologous mutation previously described in the beta globin gene, which is termed as Hb Debrousse. The patient fully recovered by 9 months of age as expected with the transition from fetal to adult hemoglobin. 相似文献
93.
94.
Sarah Bonk MD Martina Kluth PhD Kristina Jansen MD Claudia Hube-Magg PhD Georgia Makrypidi-Fraune PhD Doris Höflmayer MD Sören Weidemann MD Katharina Möller MD Ria Uhlig MD Franziska Büscheck MD Andreas M. Luebke MD Eike Burandt MD Till S. Clauditz MD Stefan Steurer MD Thorsten Schlomm MD Hartwig Huland MD Hans Heinzer MD Guido Sauter MD Ronald Simon PhD David Dum MD 《The Prostate》2020,80(13):1097-1107
95.
Baum Sven Holger Oeverhaus Michael Saxe Franziska Mohr Christopher 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(10):2305-2312
Graefe's Archive for Clinical and Experimental Ophthalmology - This study aims to analyse the various modifications of orbital exenteration. Patients undergoing orbital exenteration from March... 相似文献
96.
Matthias Vonmoos Lea M Hulka Katrin H Preller Franziska Minder Markus R Baumgartner Boris B Quednow 《Neuropsychopharmacology》2014,39(9):2200-2210
Cocaine users consistently display cognitive impairments. However, it is still unknown whether these impairments are cocaine-induced and if they are reversible. Therefore, we examined the relation between changing intensity of cocaine use and the development of cognitive functioning within 1 year. The present data were collected as part of the longitudinal Zurich Cocaine Cognition Study (ZuCo2St). Forty-eight psychostimulant-naive controls and 57 cocaine users (19 with increased, 19 with decreased, and 19 with unchanged cocaine use) were eligible for analysis. At baseline and after a 1-year follow-up, cognitive performance was measured by a global cognitive index and four neuropsychological domains (attention, working memory, declarative memory, and executive functions), calculated from 13 parameters of a broad neuropsychological test battery. Intensity of cocaine use was objectively determined by quantitative 6-month hair toxicology at both test sessions. Substantially increased cocaine use within 1 year (mean +297%) was associated with reduced cognitive performance primarily in working memory. By contrast, decreased cocaine use (−72%) was linked to small cognitive improvements in all four domains. Importantly, users who ceased taking cocaine seemed to recover completely, attaining a cognitive performance level similar to that of the control group. However, recovery of working memory was correlated with age of onset of cocaine use—early-onset users showed hampered recovery. These longitudinal data suggest that cognitive impairment might be partially cocaine-induced but also reversible within 1 year, at least after moderate exposure. The reversibility indicates that neuroplastic adaptations underlie cognitive changes in cocaine users, which are potentially modifiable in psychotherapeutical or pharmacological interventions. 相似文献
97.
Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor 总被引:3,自引:0,他引:3 下载免费PDF全文
Prawitt D Enklaar T Gärtner-Rupprecht B Spangenberg C Oswald M Lausch E Schmidtke P Reutzel D Fees S Lucito R Korzon M Brozek I Limon J Housman DE Pelletier J Zabel B 《Proceedings of the National Academy of Sciences of the United States of America》2005,102(11):4085-4090
We have analyzed several cases of Beckwith-Wiedemann syndrome (BWS) with Wilms' tumor in a familial setting, which give insight into the complex controls of imprinting and gene expression in the chromosome 11p15 region. We describe a 2.2-kbp microdeletion in the H19/insulin-like growth factor 2 (IGF2)-imprinting center eliminating three target sites of the chromatin insulator protein CTCF that we believe here is necessary, but not sufficient, to cause BWS and Wilms' tumor. Maternal inheritance of the deletion is associated with IGF2 loss of imprinting and up-regulation of IGF2 mRNA. However, in at least one affected family member a second genetic lesion (a duplication of maternal 11p15) was identified and accompanied by a further increase in IGF2 mRNA levels 35-fold higher than control values. Our results suggest that the combined effects of the H19/IGF2-imprinting center microdeletion and 11p15 chromosome duplication were necessary for manifestation of BWS. 相似文献
98.
LYVE-1 (lymphatic endothelium hyaluronan receptor) has been identified as a powerful marker for lymphatic endothelium. Apart from lymphatic endothelium, LYVE-1 is expressed in normal liver blood sinusoids, spleen endothelium and activated tissue macrophages. LYVE-1 has not been detected in blood vascular endothelium with the exception of blood vessels in the lung. High endothelial venules (HEVs) belong to the vascular compartment of lymph nodes. They are the major site of entry for circulating lymphocytes into the node. HEVs are characterized by cuboidal endothelial cells, the existence of discontinuous junctions between these endothelial cells, and the presence of large numbers of lymphocytes within their walls. 40 paraffin-embedded lymph node biopsy specimens from newly diagnosed patients with non-Hodgkin lymphoma were evaluated as well as 10 lymph node biopsy specimens from adult patients with reactive lymphadenitis, and 10 normal, non-metastatic lymph nodes obtained from adult patients during cancer surgery served as controls. Samples were fixed in 10% buffered formalin, paraffin embedded, and stained with hematoxylin and eosin for histopathological evaluation. Sections were also evaluated with mouse monoclonal antibodies against LYVE-1 and CD34, and expression of both LYVE-1 and CD34 was demonstrated in HEVs. LYVE-1 expression was also found on the endothelial cells of the lymphatic sinus and in reticular cells in the lymph nodes. 相似文献
99.
Haasen C Prinzleve M Zurhold H Rehm J Güttinger F Fischer G Jagsch R Olsson B Ekendahl M Verster A Camposeragna A Pezous AM Gossop M Manning V Cox G Ryder N Gerevich J Bacskai E Casas M Matali JL Krausz M 《European addiction research》2004,10(4):139-146
An increase in the use of cocaine and crack in several parts of Europe has raised the question whether this trend is similar to that of the USA in the 1980s. However, research in the field of cocaine use in Europe has been only sporadic. Therefore, a European multi-centre and multi-modal project was designed to study specific aspects of cocaine and crack use in Europe, in order to develop guidelines for public health strategies. Data on prevalence rates were analysed for the general population and for specific subgroups. Despite large differences between countries in the prevalence of cocaine use in the general population, most countries show an increase in the last few years. The highest rate with a lifetime prevalence of 5.2% was found for the United Kingdom, although with a plateau effect around the year 2000. With regard to specific subgroups, three groups seem to show a higher prevalence than the general population: (1) youth, especially in the party scene; (2) socially marginalized groups, such as homeless and prostitutes or those found in open drug scenes; (3) opiate-dependent patients in maintenance treatment who additionally use cocaine. Specific strategies need to be developed to address problematic cocaine use in these subgroups. 相似文献