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951.
Barrou Diallo Florent Dolidon Jean‐Marcel Travere Bernard Mazoyer 《Human brain mapping》1999,7(2):136-150
We propose a hardware and software architecture to respond to crucial problems in the neuroimaging field: storage, retrieval, and processing of large datasets. The B‐SPID project, here discussed, concerns the processing of neuroimages and attached components stored in an object‐relational multimedia database management system (DBMS). Advanced bioinformation concepts are exploited in this project such as large scale data storage, high level graphical user interfaces and 3D graphical processing and display of data. Our database implementation is based on standard programming components, runs on several UNIX platforms and is written to be evolutive. Queries on this database are designed to obtain and display from neuroimaging data several types of results (pictures, text, or 3D graphical shapes) on heterogeneous systems. Hum. Brain Mapping 7:136–150, 1999. © 1999 Wiley‐Liss, Inc. 相似文献
952.
Batrice Le Vu Florent de Vathaire Akhtar Shamsaldin Michael M. Hawkins Emmanuel Grimaud Claire Hardiman Ibrahima Diallo Gilles Vassal Elhadie Bessa Sarah Campbell Xavier Panis Nicolas Daly-Schveitzer Jean-Lon Lagrange Jean-Michel Zucker Franois Eschwge Jean Chavaudra Jean Lemerle 《International journal of cancer. Journal international du cancer》1998,77(3):370-377
Osteosarcoma is the most frequent second primary cancer occurring during the first 20 years following treatment for a solid cancer in childhood. Using a cohort study of children treated for a solid cancer, we investigated the incidence and etiology of osteosarcoma as a second malignant neoplasm after childhood cancer in a cohort and a case-control study. We analysed the relationship between the local dose of radiation and the risk of osteosarcoma, taking into account chemotherapy received. A cohort study of 4,400 3-year survivors of a first solid cancer during childhood diagnosed in France or the United Kingdom, between 1942 and 1986, revealed 32 subsequent osteosarcomas. In a nested case-control study, we matched 32 cases and 160 controls for sex, type of first cancer, age at first cancer and the duration of follow-up. Parameters studied were the incidence of osteosarcoma, the cumulative local dose of irradiation and the cumulative dose of chemotherapy received by cases and controls. The risk of a osteosarcoma was found to be a linear function of the local dose of radiation (excess relative risk per gray = 1.8), and was found to increase with the number of moles of electrophilic agents per square meter but not with other drugs. No interaction was noted between radiotherapy and chemotherapy. Bilateral retinoblastoma, Ewing's sarcoma and soft tissue sarcoma were found to render patients susceptible to a higher risk of developing an osteosarcoma as a second malignant neoplasm. We recommend long-term surveillance of patients who were treated during childhood for bilateral retinoblastoma, Ewing's sarcoma, soft tissue sarcoma, as well as other first cancer treated with radiotherapy plus high doses of chemotherapy, without focusing exclusively on the radiation field. Int. J. Cancer 77:370–377, 1998. © 1998 Wiley-Liss, Inc. 相似文献
953.
Penzenstadler Louise Chatton Anne Huguelet Philippe Lecardeur Laurent Bartolomei Javier Brazo Perrine Murys Elodie Poupart Florent Rouvière Serge Saoud Mohamed Favrod Jérôme Khazaal Yasser 《The Psychiatric quarterly》2019,90(4):693-702
Psychiatric Quarterly - Delusional beliefs and their behavioral consequences are predominant symptoms in patients with psychosis and play an important role in the treatment. Delusional beliefs are... 相似文献
954.
Elise Pommaret Ariane Vienne Jérémie H. Lefevre Philippe Sogni Christian Florent Benoît Desaint Yann Parc 《Surgical endoscopy》2013,27(10):3816-3822
Background
Restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) has become the treatment of choice in familial adenomatous polyposis (FAP) to prevent the risk of colorectal cancer. However, it currently is recognized that adenomas may develop in the ileal pouch. The risk of adenoma occurring in the afferent ileal loop above the pouch is less clearly identified. This study aimed to evaluate the difference in prevalence of adenomas between the ileal pouch and the afferent ileum after IPAA in FAP.Methods
The study analyzed 442 endoscopies performed between 2003 and 2008 for 139 FAP patients. The patients had undergone an IPAA in 118 cases, an ileorectal anastomosis in 13 cases, or an ileostomy in 8 cases.Results
Among the 118 IPAA patients, 57 (48.3 %) had pouch adenomas a median of 15 years after surgery. The risk factors for pouch adenomas were delay since pouch construction [odds ratio (OR), 1.11; p = 0.016] and presence of advanced duodenal adenomas (OR, 4.35; p = 0.011). Seven patients had pouch adenomas with high-grade dysplasia. Only nine patients had afferent ileal loop adenomas (6.5 %). The only significant risk factor for ileal adenomas was the presence of pouch adenomas (OR, 2.16; p = 0.007).Conclusion
After restorative proctocolectomy in FAP, adenoma recurrence is frequent in the pouch, with a higher risk for patients with advanced duodenal adenomas and an increasing risk over time, whereas adenomas are rarely found in the afferent ileal loop. This finding may help to propose redo ileal pouch anal anastomosis if required. 相似文献955.
Canard G Lefevre JH Colas C Coulet F Svrcek M Lascols O Hamelin R Shields C Duval A Fléjou JF Soubrier F Tiret E Parc Y 《Annals of surgical oncology》2012,19(3):809-816
Purpose
The purpose of this study was to assess the efficacy of screening for the detection of Lynch syndrome (LS) in an unselected population undergoing surgery for a colorectal cancer.Methods
A total of 1,040 patients were prospectively included between 2005 and 2009. LS screening modalities included the Bethesda criteria, immunochemistry (IHC) for MLH1, MSH2, and MSH6, and microsatellite instability (MSI) by using pentaplex markers. Promoter methylation was assessed in tumors with a loss of MLH1 expression. Gene sequencing was offered to patients with abnormal IHC or MSI status without promoter methylation.Results
A total of 105 patients had an abnormal result: 102 (9.8%) exhibited a loss of protein on IHC and 98 (9.4%) had MSI. A discordant result was observed in 10 patients with eventual proven LS in 6 patients. Loss of MLH1 (n?=?64) was due to promoter methylation in 43 patients (67.2%). Overall, of 62 patients with an abnormal result, 38 had genetic sequencing leading to 25 (65.8%) identified with a germ-line mutation. Loss of MSH2 on IHC was associated with a mutation in 78.3% (18 of 23) of cases. Among the 62 patients with abnormal results, 23 (37.1%) did not meet the Bethesda criteria.Conclusions
Strict application of the Bethesda criteria does not lead to identification of all patients with LS. IHC and MSI testing are complementary methods and should be used in association to identify potential LS patients. 相似文献956.
C?me Fruit Sophie Guillotin Marie Wolfrum Thomas Lanot Florent Battefort Pierre Girardie Marie Rafiq Nicolas Delcourt 《世界急诊医学杂志(英文)》2023,14(2):152-154
<正>Dear editor, Isopropanol, also named 2-propanol or isopropyl alcohol(IPA), is a colorless, volatile liquid found in numerous household chemicals, such as cleaners and disinfectants, which typically contain a 70% solution of IPA in water. IPA is also extensively used in industry and laboratories as a solvent. 相似文献
957.
Survival for glioma patients has shown minimal improvement over the past 20 years. The ability to detect and monitor gliomas relies primarily upon imaging technologies that lack sensitivity and specificity, especially during the post-surgical treatment phase. Treatment-response monitoring with an effective liquid-biopsy paradigm may also provide the most facile clinical scenario for liquid-biopsy integration into brain-tumour care. Conceptually, liquid biopsy is advantageous when compared with both tissue sampling (less invasive) and imaging (more sensitive and specific), but is hampered by technical and biological problems. These problems predominantly relate to low concentrations of tumour-derived DNA in the bloodstream of glioma patients. In this review, we highlight methods by which the neuro-oncological scientific and clinical communities have attempted to circumvent this limitation. The use of novel biological, technological and computational approaches will be explored. The utility of alternate bio-fluids, tumour-guided sequencing, epigenomic and fragmentomic methods may eventually be leveraged to provide the biological and technological means to unlock a wide range of clinical applications for liquid biopsy in glioma.Subject terms: CNS cancer, Next-generation sequencing, Biomarkers 相似文献
958.
Lauranne Scheldeman MD Anke Wouters MD PhD Florent Boutitie PhD Patrick Dupont PhD Soren Christensen PhD Bastian Cheng MD Martin Ebinger MD Matthias Endres MD Jochen B. Fiebach MD Christian Gerloff MD Keith W. Muir MD Norbert Nighoghossian MD Salvador Pedraza MD PhD Claus Z. Simonsen MD PhD Vincent Thijs MD PhD Götz Thomalla MD Robin Lemmens MD PhD for the WAKE-UP Investigators 《Annals of neurology》2020,87(6):931-938
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