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排序方式: 共有1175条查询结果,搜索用时 31 毫秒
911.
912.
Marie Beylot-Barry Diane Mermin Aline Maillard Reda Bouabdallah Nathalie Bonnet Anne-Bénédicte Duval-Modeste Laurent Mortier Saskia Ingen-Housz-Oro Caroline Ram-Wolff Stéphane Barete Stéphane Dalle Eve Maubec Gaelle Quereux Isabelle Templier Martine Bagot Florent Grange Pascal Joly Béatrice Vergier Jean-Philippe Merlio 《The Journal of investigative dermatology》2018,138(9):1982-1989
913.
Florent Gobert Frederic Dailler Catherine Fischer Nathalie André-Obadia Jacques Luauté 《Clinical neurophysiology》2018,129(6):1105-1116
Objectives
Several studies have shown that bilateral abolition of somatosensory evoked potentials after a nontraumatic coma has 100% specificity for nonawakening with ethical consequences for active care withdrawal. We propose to evaluate the prognostic value of bilateral abolished cortical components of SEPs in severe vascular coma.Methods
A total of 144 comatose patients after subarachnoid haemorrhage were evaluated by multimodal evoked potentials (EPs); 7 patients presented a bilateral abolition of somatosensory and auditory EPs. Their prognosis value was interpreted with respect to brainstem auditory EPs, EEG, and structural imaging.Results
One patient emerged from vegetative state during follow-up; 6 patients did not return to consciousness. The main neurophysiological difference was a cortical reactivity to pain preserved in the patient who returned to consciousness. This patient had focal sub-cortical lesions, which could explain the abolition of primary cortical components by a bilateral deafferentation of somatosensory and auditory pathways.Conclusions
This is the first report of a favourable outcome after a multimodal abolition of primary cortex EPs in vascular coma. For the 3 cases of vascular coma with preserved brainstem function, EEG reactivity and cortical EPs were abolished by a diffuse ischaemia close to cerebral anoxia.Significance
The complementarity of EPs, EEG, and imaging must be emphasised if therapeutic limitations are considered to avoid over-interpretation of the prognosis value of EPs. 相似文献914.
Meyer F Dimitrova M Jedrzejenska J Arntz Y Schaaf P Frisch B Voegel JC Ogier J 《Biomaterials》2008,29(5):618-624
In an effort to develop new biomaterial coatings, it was shown that polyelectrolyte multilayers constitute a very powerful tool to render surfaces biologically active. The challenge is to multi-functionalize surfaces in a controlled way. We show here, for the first time, that it is possible to functionalize multilayer films simultaneously with two molecules acting in totally different ways on cells, namely plasmid DNA (pDNA), pre-complexed with poly(ethyleneimine) (PEI), and a peptide molecule, NDPMSH. This peptide, grafted to poly(L-glutamic acid) (PGA) was used as a signal molecule for melanoma cells B16-F1 and for its ability to enhance gene delivery in a receptor-independent manner. The PGA-NDPMSH chains are embedded in poly-(allylamine hydrochloride)/poly-(sodium 4-styrene sulfonate) multilayers and the pDNA-PEI complexes are deposited on top of the films. It is shown that melanoma cells (B16-F1) are efficiently transfected after 24h of contact with functionalized films. When brought in contact with Huh-7 cells that do not express the peptide receptors, these films trigger significantly the transfection rate, showing that it is possible to enhance the transfection process by incorporating specific peptides into multilayer films. Moreover, transfected cells sorted by flow cytometry produce melanin, demonstrating both activation via the peptide signaling pathway and cell transfection. 相似文献
915.
Barbieri G Gissot AS Fouque F Casillas JM Pozzo T Pérennou D 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2008,185(4):545-552
The representation of the vertical can be assessed by measuring the visual, tactile or perception of the postural vertical
(PV). It is well accepted that visceral graviceptors and Golgi tendon receptors contribute to perception of the PV, whereas
the role of muscular proprioception (Ia muscle spindles) remains to be clarified. The objective of this study was to analyze
whether or not muscular proprioception contributes to the representation of verticality. We hypothesized that the modulation
of proprioception by appropriate tendinomuscular vibration may tilt the PV. We present two experiments that explore this hypothesis.
PV was firstly measured in the pitch plane in twelve healthy subjects in two conditions: baseline and vibration of both Achilles
tendons during six minutes, according to a counterbalanced presentation. PV orientation (mean) and dispersion (standard deviation)
were calculated on the six measurements per condition. Vibration of the Achilles tendons induced a systematic backward tilt
of PV (2.7° ± 0.8° on average; P < 10−3), and no significant changes regarding PV dispersion. A clear post-effect was found for PV orientation in subjects who started
the experiment with the condition vibration on. The possibility that PV could also be modulated by a much shorter duration
of vibration (less than 8 s of vibration) was analyzed in a second experiment using a similar general procedure but a simplified
experimental plane in other subjects. Again a backward PV tilt was induced by the vibration, but with a magnitude lower than
that found in the first experiment, and with no post-effect. Since body geometry was unchanged, these two studies mean that
proprioception contributes to the representation of the vertical. In conclusion, this study brings new insights to our understanding
of the sense of verticality and contributes to the interpretation of backward falls induced by vibration. The induced backward
fall is partly due to alignment of the erect posture with a backward-tilted referential of verticality. 相似文献
916.
917.
Surgical resection and chemotherapy are the mainstay of the treatment for undifferentiated embryonal sarcoma of the liver. Whether neoadjuvant chemotherapy shou... 相似文献
918.
919.
920.
Florent Lalys Claire Haegelen Jean-Christophe Ferre Omar El-Ganaoui Pierre Jannin 《NeuroImage》2010,49(1):345-354
New MR imaging protocols enable visualization of brain structures. However, for dedicated clinical applications such as targeting deep brain stimulation (DBS), a more accurate localization requires the use of atlases. We developed a three-dimensional digitized mono-subject anatomical template of the human brain based on 3-T magnetic resonance images (MRI). By averaging 15 registered T1 image acquisitions, we have shown that the final image corresponds to an optimal image, limited by the performance of the 3-T MR machine. We compared different preprocessing workflows for template construction. With the optimal strategy, along with validated existing processing methods, one T1 template and one T1–T2 mixing template were created in order to improve visualization of spatially complex deep structures. Reduction of voxel size to 0.25 mm3 was also advantageous to observe fine structures and white matter/gray matter intensity crossings. Results demonstrated that such a template also improved inter-patient registration for population comparison in DBS. These MR templates are made freely available to our community (http://www.vmip.org/mritemplate) to serve as a reference for neuroimage processing methods. 相似文献